p-TIAM1 exchanges GTP for GDP on RAC1, activating it

Stable Identifier
R-HSA-4093336
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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p-TIAM1 exchanges GTP for GDP on RAC1, activating it
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Phosphorylated T-lymphoma invasion and metastasis-inducing protein 1 (p-TIAM1) bound to EPHB complexes containing NMDARs, promotes spine morphogenesis by activating RAC1, which triggers actin cytoskeletal remodelling that is essential for spine development (Tolias et al. 2007, Tolias et al. 2005).
Literature References
PubMed ID Title Journal Year
15721239 The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines

Tolias, KF, Bikoff, JB, Burette, A, Paradis, S, Harrar, D, Tavazoie, S, Weinberg, RJ, Greenberg, ME

Neuron 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane]

Physical Entity
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Danio rerio)
p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)
p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)
p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-08-14)
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