Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SPP1(17-?) [extracellular region]
Stable Identifier
R-HSA-4093351
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
SPP1 N-terminal fragment, Bone sialoprotein 1, Osteopontin, Secreted phosphoprotein 1
Locations in the PathwayBrowser for interactor UniProt:P62166 NCS1
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
OPN (osteopontin) degradation by MMP3, MMP7 (Homo sapiens)
SPP1(17-?) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10451 SPP1
Gene Names
SPP1, Osteopontin, BNSP, OPN, PSEC0156
Chain
signal peptide:1-16, chain:17-314
Reference Genes
BioGPS Gene:6696 SPP1
COSMIC (genes):SPP1 SPP1
CTD Gene:6696 SPP1
dbSNP Gene:6696 SPP1
ENSEMBL:ENSG00000118785 SPP1
HGNC:11255 SPP1
KEGG:hsa:6696 SPP1
Monarch:6696 SPP1
NCBI Gene:6696 SPP1
OMIM:166490 SPP1
UCSC:P10451 SPP1
Reference Transcript
RefSeq:NM_001040060.1 SPP1
RefSeq:NM_000582.2 SPP1
RefSeq:NM_001251830.1 SPP1
RefSeq:NM_001251829.1 SPP1
RefSeq:NM_001040058.1 SPP1
Other Identifiers
11727790_x_at
11737943_a_at
11737944_x_at
11746506_a_at
11754604_x_at
11755730_x_at
16968680
2092_s_at
209875_PM_s_at
209875_s_at
2735055
2735056
2735057
2735058
2735059
2735060
2735061
2735062
2735063
2735064
2735065
2735066
2735067
2735068
2735069
2735070
2735071
2735072
34342_s_at
6696
74815_at
8096301
A_14_P108101
A_14_P113818
A_23_P7313
GE61335
GO:0001503
GO:0001649
GO:0005125
GO:0005178
GO:0005515
GO:0005576
GO:0005615
GO:0005788
GO:0005794
GO:0006355
GO:0006629
GO:0006710
GO:0007155
GO:0007165
GO:0007566
GO:0022414
GO:0030154
GO:0031214
GO:0031982
GO:0033280
GO:0036005
GO:0036094
GO:0042995
GO:0043226
GO:0045780
GO:0045893
GO:0046697
GO:0048018
GO:0048471
GO:0048545
GO:0048685
GO:0048856
GO:0050840
GO:0070062
GO:0071394
GO:0098772
GO:1904612
GO:2000866
HMNXSV003007166
HMNXSV003024968
ILMN_1651354
ILMN_2374449
PH_hs_0028680
TC04000478.hg
TC04002100.hg
U20758_rna1_at
g189150_3p_a_at
Participates
as an output of
OPN (osteopontin) degradation by MMP3, MMP7 (Homo sapiens)
Other forms of this molecule
SPP1 [extracellular region]
SPP1 [endoplasmic reticulum lumen]
p-SPP1 [endoplasmic reticulum lumen]
SPP1(?-314) [extracellular region]
Inferred To
SPP1(17-?) [extracellular region]
(Gallus gallus)
SPP1 [extracellular region]
(Bos taurus)
SPP1 [extracellular region]
(Canis familiaris)
SPP1 [extracellular region]
(Sus scrofa)
Spp1 [extracellular region]
(Mus musculus)
Spp1 [extracellular region]
(Rattus norvegicus)
spp1 [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_001035149.1
,
NP_001035147.1
,
NP_000573.1
,
NP_001238758.1
,
NP_001238759.1
OpenTargets
ENSG00000118785
ENSEMBL
ENSP00000354042
,
ENST00000360804
,
ENSP00000378517
,
ENST00000395080
,
ENSP00000477824
,
ENST00000237623
,
ENST00000614857
,
ENSP00000237623
HPA
ENSG00000118785-SPP1
PRO
P10451
Pharos - Targets
P10451
Orphanet
SPP1
GlyGen
P10451
PDB
3DSF
,
3CXD
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43765 SGTA
1
SGTA [cytosol]
(R-HSA-5423595)
0.83
8
UniProt:Q8IXL6 FAM20C
1
FAM20C [endoplasmic reticulum lumen]
(R-HSA-8952276)
0.636
3
UniProt:O43681 GET3
1
ASNA1 [cytosol]
(R-HSA-9609520)
0.556
3
UniProt:P46379-2 BAG6
0.556
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q96EQ0 SGTB
0.556
3
UniProt:P62166 NCS1
0.556
3
UniProt:P16070 CD44
2
CD44 [plasma membrane]
(R-HSA-1031688)
CD44 [secretory granule membrane]
(R-HSA-6804776)
0.507
4
UniProt:Q9NRR5 UBQL4
0.488
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text