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CTSL2 [endolysosome lumen]
Stable Identifier
R-HSA-4127477
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endolysosome lumen
Synonyms
Cathepsin L2, Cathepsin V, CATL2_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Trafficking and processing of endosomal TLR (Homo sapiens)
TLR9 processing at neutral pH (Homo sapiens)
CTSS-like proteins [endolysosome lumen] (Homo sapiens)
CTSL2 [endolysosome lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60911 CTSV
Gene Names
CTSV, CATL2, CTSL2, CTSU, UNQ268/PRO305
Chain
signal peptide:1-17, propeptide:18-113, chain:114-334
Reference Genes
BioGPS Gene:1515 CTSV
COSMIC (genes):CTSV CTSV
CTD Gene:1515 CTSV
dbSNP Gene:1515 CTSV
ENSEMBL:ENSG00000136943 CTSV
ENSEMBL_homo_sapiens_GENE:ENSG00000136943.12 CTSV
HGNC:2538 CTSV
KEGG Gene (Homo sapiens):1515 CTSV
Monarch:1515 CTSV
NCBI Gene:1515 CTSV
OMIM:603308 CTSV
UCSC:O60911 CTSV
Reference Transcript
RefSeq:NM_001333.3 CTSV
RefSeq:NM_001201575.1 CTSV
Other Identifiers
11748773_a_at
11748774_x_at
11755521_a_at
1515
17096285
210074_PM_at
210074_at
3178170
3178184
3216675
3216676
3216677
3216679
3216680
3216684
3216686
3216687
3216689
3216690
3216691
3216692
3216693
3216694
3287613
3288119
40717_at
8162652
A_21_P0013703
A_23_P146456
GE53032
GE545996
GE794882
GO:0002376
GO:0003824
GO:0004197
GO:0004252
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0006508
GO:0006915
GO:0006955
GO:0008233
GO:0008234
GO:0008656
GO:0012501
GO:0016787
GO:0019886
GO:0022617
GO:0023052
GO:0030163
GO:0030198
GO:0043202
GO:0043226
GO:0051603
GO:0098772
GO:0140096
GO:2001235
HMNXSV003019892
Hs2.353110.1.S1_3p_at
Hs2.353110.1.S1_3p_x_at
ILMN_1748352
PH_hs_0031390
TC09001381.hg
g3228671_3p_at
p16864
Participates
as a candidate of
CTSS-like proteins [endolysosome lumen] (Homo sapiens)
Other forms of this molecule
CTSL2 [lysosomal lumen]
CTSL2 [early endosome lumen]
CTSL2 [extracellular region]
Inferred To
Ctsl [endolysosome lumen]
(Mus musculus)
Ctsl [endolysosome lumen]
(Rattus norvegicus)
CTSL [endolysosome lumen]
(Bos taurus)
CTSL [endolysosome lumen]
(Canis familiaris)
CTSL [endolysosome lumen]
(Sus scrofa)
Cross References
RefSeq
NP_001188504.1
,
NP_001324.2
ZINC - World Drugs
CATL2_HUMAN
Guide to Pharmacology - Targets
2352
OpenTargets
ENSG00000136943
ZINC - FDA approved
CATL2_HUMAN
ZINC - Substances
CATL2_HUMAN
ZINC - Biogenic
CATL2_HUMAN
ZINC target
O60911
PRO
O60911
PDB
7QFH
,
7Q8Q
,
7Q8H
,
7Q8P
,
7Q8I
,
7QGW
,
7Q8N
,
7Q8G
,
7Q8O
,
7QFF
,
7Q9H
,
7QO2
,
7QNS
,
1FH0
,
7Q8L
,
7Q8M
,
7Q8F
,
7Q8D
,
7QHJ
,
7Q8J
,
3KFQ
,
7Q8K
,
7PK4
,
3H6S
,
7QHK
ZINC - Investigational
CATL2_HUMAN
ZINC - Metabolites
CATL2_HUMAN
GeneCards
O60911
HPA
ENSG00000136943-CTSV
Ensembl
ENSP00000259470
,
ENSG00000136943
,
ENST00000679661
,
ENSP00000505681
,
ENSP00000505141
,
ENST00000259470
,
ENST00000681737
,
ENSP00000506713
,
ENST00000681927
Pharos - Targets
O60911
ZINC - Predictions - Purchasable
CATL2_HUMAN
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P43235 CTSK
3
CTSK [lysosomal lumen]
(R-HSA-1181226)
CTSK [extracellular region]
(R-HSA-2470897)
CTSK [endolysosome lumen]
(R-HSA-1678985)
0.527
2
UniProt:Q15915 ZIC1
1
ZIC1 [nucleoplasm]
(R-HSA-9731648)
0.527
2
UniProt:Q9NYY3 PLK2
1
PLK2 [cytosol]
(R-HSA-6801636)
0.527
2
UniProt:P01160 NPPA
5
NPPA(124-151) [extracellular region]
(R-HSA-5578799)
NPPA(1-151) [extracellular region]
(R-HSA-976950)
NPPA(1-25) [extracellular region]
(R-HSA-5578791)
NPPA(56-123) [extracellular region]
(R-HSA-5578797)
NPPA(26-55) [extracellular region]
(R-HSA-5578794)
0.527
2
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