Reactome | AKAP5 [cytosol]

AKAP5 [cytosol]

Stable Identifier

R-HSA-416331

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AKAP79

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
      - Trafficking of AMPA receptors (Homo sapiens)
        
        Trafficking of GluR1-containing AMPA receptors (Homo sapiens)
        
        AKAP5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P24588 AKAP5

Gene Names

AKAP5, AKAP79

Chain

chain:1-427

Reference Genes

BioGPS Gene:9495 AKAP5

COSMIC (genes):AKAP5 AKAP5

CTD Gene:9495 AKAP5

dbSNP Gene:9495 AKAP5

ENSEMBL:ENSG00000179841 AKAP5

ENSEMBL_homo_sapiens_GENE:ENSG00000179841.8 AKAP5

HGNC:375 AKAP5

KEGG Gene (Homo sapiens):9495 AKAP5

Monarch:9495 AKAP5

NCBI Gene:9495 AKAP5

OMIM:604688 AKAP5

UCSC:P24588 AKAP5

Reference Transcript

RefSeq:NM_004857.3 AKAP5

Other Identifiers

11729077_at

11745674_a_at

16785361

207800_PM_at

207800_at

230846_PM_at

230846_at

32421_at

3540069

3540070

3540071

3540072

3540073

3540075

3540077

3540078

3540080

3540082

3540084

50873_r_at

7975066

9495

A_14_P101726

A_23_P106103

GE81448

GO:0005515

GO:0005516

GO:0005768

GO:0005829

GO:0005886

GO:0006886

GO:0007165

GO:0007193

GO:0007194

GO:0007268

GO:0008179

GO:0008287

GO:0009898

GO:0010738

GO:0014069

GO:0016020

GO:0016192

GO:0017124

GO:0023052

GO:0030346

GO:0031410

GO:0031698

GO:0032590

GO:0034237

GO:0035254

GO:0043197

GO:0043226

GO:0045121

GO:0045202

GO:0045762

GO:0050811

GO:0051018

GO:0055085

GO:0060076

GO:0060090

GO:0070886

GO:0072659

GO:0097110

GO:0098837

GO:0098944

GO:1900273

GO:1903078

GO:1905665

GO:1905751

HMNXSV003051309

Hs.22902.0.A1_3p_at

ILMN_1690818

M90359_at

PH_hs_0003411

TC14000389.hg

TC14001730.hg

g4757739_3p_at

Participates

as an input of

Trafficking of GluR1-containing AMPA receptors (Homo sapiens)

Other forms of this molecule

AKAP5 [plasma membrane]

Inferred To

AKAP5 [cytosol] (Bos taurus)

AKAP5 [cytosol] (Canis familiaris)

AKAP5 [cytosol] (Gallus gallus)

AKAP5 [cytosol] (Sus scrofa)

Akap5 [cytosol] (Mus musculus)

Akap5 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_004848.3

OpenTargets

ENSG00000179841

HPA

ENSG00000179841-AKAP5

GeneCards

P24588

Ensembl

ENST00000320636, ENSG00000179841, ENSP00000378207, ENST00000394718, ENSP00000315615

PRO

P24588

Pharos - Targets

P24588

HMDB Protein

HMDBP08108

PDB

5NIN, 2H9R, 3LL8

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13861 PRKAR2A	2	PRKAR2A [cytosol] (R-HSA-57840) PRKAR2A [ciliary base] (R-HSA-5610412)	0.76	5
UniProt:P31323 PRKAR2B	2	PRKAR2B [ciliary base] (R-HSA-5610414) PRKAR2B [cytosol] (R-HSA-57842)	0.742	5
UniProt:P22694 PRKACB	3	PRKACB [ciliary base] (R-HSA-5610404) PRKACB [cytosol] (R-HSA-57846) PRKACB [nucleoplasm] (R-HSA-111937)	0.725	4
UniProt:P17612 PRKACA	4	PRKACA [mitochondrial matrix] (R-HSA-9838291) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.725	4
UniProt:Q08209-1 PPP3CA			0.648	6
UniProt:P63098 PPP3R1	2	PPP3R1 [nucleoplasm] (R-HSA-2685631) PPP3R1 [cytosol] (R-HSA-51291)	0.591	4
UniProt:P10644 PRKAR1A	4	PRKAR1A(1-183)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713476) PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713471) PRKAR1A [ciliary base] (R-HSA-5610408) PRKAR1A [cytosol] (R-HSA-57836)	0.556	3
UniProt:Q08209-2 PPP3CA			0.556	3
UniProt:Q9HAT0 ROPN1	1	ROPN1 [cytosol] (R-HSA-5667048)	0.556	3
UniProt:Q96C74 ROP1L			0.556	3
UniProt:P63252 KCNJ2	1	KCNJ2 [plasma membrane] (R-HSA-975378)	0.536	2
UniProt:P22612 PRKACG	3	PRKACG [ciliary base] (R-HSA-5610405) PRKACG [cytosol] (R-HSA-57848) PRKACG [nucleoplasm] (R-HSA-111938)	0.527	2
UniProt:P35561 Kcnj2	2	Kcnj2 [plasma membrane] (R-MMU-9729868) Kcnj2 [plasma membrane] (R-MMU-975378)	0.524	2