Reactome | DLG1 [cytosol]

DLG1 [cytosol]

Stable Identifier

R-HSA-416332

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Disks large homolog 1, DLG1_HUMAN

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Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
      - Trafficking of AMPA receptors (Homo sapiens)
        
        Trafficking of GluR1-containing AMPA receptors (Homo sapiens)
        
        DLG1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q12959 DLG1

Gene Names

DLG1

Chain

chain:1-904

Reference Genes

BioGPS Gene:1739 DLG1

COSMIC (genes):DLG1 DLG1

CTD Gene:1739 DLG1

dbSNP Gene:1739 DLG1

ENSEMBL:ENSG00000075711 DLG1

HGNC:2900 DLG1

KEGG:hsa:1739 DLG1

Monarch:1739 DLG1

NCBI Gene:1739 DLG1

OMIM:601014 DLG1

UCSC:Q12959 DLG1

Reference Transcript

Participates

as an input of

Trafficking of GluR1-containing AMPA receptors (Homo sapiens)

Other forms of this molecule

DLG1 [plasma membrane]

DLG1 [transport vesicle membrane]

DLG1 [endoplasmic reticulum membrane]

Inferred To

Dlg1 [cytosol] (Mus musculus)

Dlg1 [cytosol] (Rattus norvegicus)

DLG1 [cytosol] (Bos taurus)

DLG1 [cytosol] (Canis familiaris)

DLG1 [cytosol] (Gallus gallus)

DLG1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001191316.1, NP_001191317.1, NP_001191315.1, XP_016861290.1, XP_016861308.1, XP_016861289.1, XP_016861309.1, XP_016861306.1, NP_001353148.1, XP_016861294.1, XP_016861292.1, XP_005269346.1, XP_016861298.1, NP_001350794.1, XP_016861296.1, XP_016861307.1, XP_016861291.1, NP_001353145.1, NP_001353147.1, XP_016861295.1, XP_016861297.1, NP_001091894.1, XP_016861305.1, XP_016861299.1, NP_001353144.1, NP_001353141.1, NP_001353136.1, NP_001353137.1, NP_004078.2, XP_011510805.1, XP_011510804.1, XP_011510808.1, NP_001353133.1, NP_001353138.1, NP_001353139.1, XP_011510807.1, NP_001277912.1

OpenTargets

ENSG00000075711

ENSEMBL

ENST00000661453, ENST00000666007, ENST00000659716, ENST00000448528, ENST00000667157, ENSP00000350303, ENSP00000407531, ENSP00000499657, ENSP00000499793, ENSP00000499514, ENSP00000499413, ENST00000419354, ENSP00000499437, ENSP00000499414, ENST00000663148, ENST00000655488, ENST00000452595, ENST00000443183, ENSP00000376187, ENST00000669565, ENST00000422288, ENSP00000345731, ENSP00000413238, ENSG00000075711, ENSP00000411278, ENSP00000391732, ENSP00000396658, ENST00000346964, ENST00000670935, ENST00000670455, ENST00000671185, ENST00000392382, ENST00000450955, ENSP00000499580, ENSP00000398939, ENSP00000499384, ENSP00000499542, ENSP00000499602, ENST00000357674

GeneCards

DLG1

HPA

ENSG00000075711-DLG1

PRO

Q12959

Pharos - Targets

Q12959

Orphanet

DLG1

PDB

4AMH, 7PC3, 3W9Y, 2X7Z, 8CN1, 1PDR, 8CN3, 2M3M, 3RL8, 3LRA, 2OQS, 3RL7, 4G69

Interactors (64)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06463 VE6			0.899	9
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.842	11
UniProt:Q9NS75 CYSLTR2	1	CYSLTR2 [plasma membrane] (R-HSA-416399)	0.836	10
UniProt:P03126 VE6			0.815	7
UniProt:P22459 KCNA4	1	KCNA4 [plasma membrane] (R-HSA-977474)	0.786	5
UniProt:Q13224 GRIN2B	6	GRIN2B [plasma membrane] (R-HSA-419558) p-Y-GRIN2B [plasma membrane] (R-HSA-9612185) GRIN2B [endoplasmic reticulum membrane] (R-HSA-9609765) GRIN2B [transport vesicle membrane] (R-HSA-9610568) p-Y1474-GRIN2B [plasma membrane] (R-HSA-9032602) p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane] (R-HSA-3928477)	0.786	6
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.786	7
UniProt:Q96KB5 TOPK			0.75	9
UniProt:P78536 ADAM17	6	ADAM17 [plasma membrane] (R-HSA-179878) ADAM17(215-824) [plasma membrane] (R-HSA-9663048) ADAM17 [Golgi membrane] (R-HSA-9662835) ADAM17(1-214) [Golgi membrane] (R-HSA-9662784) ADAM17(215-824) [Golgi membrane] (R-HSA-9662839) ADAM17 [endoplasmic reticulum lumen] (R-HSA-9662763)	0.741	9
UniProt:Q7Z628 NET1	1	NET1 [cytosol] (R-HSA-3006799)	0.722	8
UniProt:Q99569 PKP4	2	PKP4 [plasma membrane] (R-HSA-6814401) PKP4 [cornified envelope] (R-HSA-8847721)	0.722	5
UniProt:P17386 VE6			0.722	5
UniProt:Q14CM0 FRPD4			0.722	7
UniProt:Q9UQB3 CTND2			0.722	4
UniProt:Q5VV41 ARHGEF16	1	ARHGEF16 [cytosol] (R-HSA-2976623)	0.713	5
UniProt:O15427 SLC16A3	1	SLC16A3 [plasma membrane] (R-HSA-204390)	0.713	5
UniProt:P53778 MAPK12	3	MAPK12 [cytosol] (R-HSA-171025) p-T183,Y185-MAPK12 [cytosol] (R-HSA-171021) MAPK12 [nucleoplasm] (R-HSA-448833)	0.706	5
UniProt:P06427 VE6			0.704	6
UniProt:Q96PE1 AGRA2			0.704	5
UniProt:Q9C0D5 TANC1			0.683	6
UniProt:P36507 MAP2K2	12	p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2 Y134C [cytosol] (R-HSA-9652089) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334)	0.676	11
UniProt:P27228 VE6			0.656	6
UniProt:P89079 E4OR1			0.656	4
UniProt:P06239 LCK	4	LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940)	0.628	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.623	5
UniProt:P23508 CRCM			0.623	2
UniProt:Q8NBL3 T178A			0.623	3
UniProt:Q9P0K1 ADAM22	1	ADAM22 [plasma membrane] (R-HSA-5678678)	0.623	4
UniProt:O60447 EVI5			0.623	5
UniProt:P33402 GUCY1A2	1	GUCY1A2 [cytosol] (R-HSA-391996)	0.623	5
UniProt:P28335 HTR2C	1	HTR2C [plasma membrane] (R-HSA-390965)	0.623	3
UniProt:Q13613 MTMR1	1	MTMR1 [cytosol] (R-HSA-1604647)	0.623	3
UniProt:Q5JU85 IQEC2			0.623	3
UniProt:P34998 CRHR1	1	CRHR1 [plasma membrane] (R-HSA-420166)	0.623	4
UniProt:Q8TAA9 VANGL1	1	VANGL1 [plasma membrane] (R-HSA-9714275)	0.623	4
UniProt:Q9NYB5 SLCO1C1	1	SLCO1C1 [plasma membrane] (R-HSA-879618)	0.609	4
UniProt:Q86SQ6 AGRA1			0.609	4
UniProt:Q96A65 EXOC4	2	EXOC4 [plasma membrane] (R-HSA-264989) EXOC4 [cytosol] (R-HSA-5623381)	0.609	4
UniProt:Q14500 KCNJ12	1	KCNJ12 [plasma membrane] (R-HSA-975282)	0.609	4
UniProt:Q86UD3 MARH3			0.609	4
UniProt:P26554 VE6			0.609	4
UniProt:Q8IWK6 AGRA3			0.609	4
UniProt:P0C2L3 F163B			0.609	3
UniProt:P22460 KCNA5	1	KCNA5 [plasma membrane] (R-HSA-977472)	0.609	2
UniProt:Q14524 SCN5A	1	SCN5A [plasma membrane] (R-HSA-443382)	0.609	3
UniProt:Q15303 ERBB4			0.609	4
UniProt:Q6ZTQ3 RASF6			0.609	4
UniProt:Q86W11 ZSC30			0.609	3
UniProt:Q9P021 CRIPT			0.609	4
UniProt:P85299 PRR5	1	PRR5 [cytosol] (R-HSA-6795323)	0.609	2
UniProt:Q96DR7 ARHGEF26	1	ARHGEF26 [cytosol] (R-HSA-8873912)	0.59	4
UniProt:P25100 ADRA1D	1	ADRA1D [plasma membrane] (R-HSA-390680)	0.59	3
UniProt:P04201 MAS1	1	MAS1 [plasma membrane] (R-HSA-9944591)	0.59	3
UniProt:Q9NTX7 RNF146	1	RNF146 [cytosol] (R-HSA-3640827)	0.59	4
UniProt:A1A5B4 ANO9	1	ANO9 [plasma membrane] (R-HSA-2684954)	0.573	2
UniProt:Q9NUP9 LIN7C	2	LIN7C [plasma membrane] (R-HSA-5216165) LIN7C [transport vesicle membrane] (R-HSA-9610411)	0.527	3
UniProt:Q14168 MPP2			0.527	4
UniProt:Q9HAP6 LIN7B	2	LIN7B [transport vesicle membrane] (R-HSA-9610415) LIN7B [plasma membrane] (R-HSA-5216107)	0.527	3
UniProt:P03409 TAX			0.525	4
UniProt:Q81964 Q81964			0.525	3
UniProt:Q9IR59 Q9IR59			0.525	4
UniProt:P36809 VE6			0.525	5
UniProt:P36799 VE6			0.524	2
UniProt:O60333-3 KIF1B			0.508	4

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