Reactome | ARHGEF12 [cytosol]

ARHGEF12 [cytosol]

Stable Identifier

R-HSA-416560

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Rho guanine nucleotide exchange factor 12, ARHGC_HUMAN, LARG

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Locations in the PathwayBrowser for interactor UniProt:Q9Q2G4 Q9Q2G4

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External Reference Information

External Reference

UniProt:Q9NZN5 ARHGEF12

Gene Names

ARHGEF12, KIAA0382, LARG

Chain

initiator methionine:, chain:2-1544

Reference Genes

BioGPS Gene:23365 ARHGEF12

COSMIC (genes):ARHGEF12 ARHGEF12

CTD Gene:23365 ARHGEF12

dbSNP Gene:23365 ARHGEF12

ENSEMBL:ENSG00000196914 ARHGEF12

HGNC:14193 ARHGEF12

KEGG:hsa:23365 ARHGEF12

Monarch:23365 ARHGEF12

NCBI Gene:23365 ARHGEF12

OMIM:604763 ARHGEF12

UCSC:Q9NZN5 ARHGEF12

Reference Transcript

Other Identifiers

11731442_at

11731443_a_at

11731444_a_at

11750580_x_at

11761978_at

11762742_at

1555498_PM_at

1555498_at

1559833_PM_at

1559833_at

1570471_3p_at

1570471_PM_at

1570471_at

16732428

201333_PM_s_at

201333_s_at

201334_PM_s_at

201334_s_at

201335_PM_s_at

201335_s_at

23365

234129_PM_at

234129_at

3352502

3352504

3352505

3352506

3352507

3352508

3352521

3352522

3352532

3352533

3352534

3352535

3352536

3352537

3352539

3352540

3352544

3352548

3352549

3352551

3352553

3352555

3352556

3352557

3352558

3352559

3352560

3352561

3352563

3352564

3352565

3352566

3352567

3352568

3352569

3352570

3352571

3352572

3352573

3352574

3352575

3352576

3352577

3352578

3352579

3352580

3352581

3352582

3352583

3352584

3352585

3352586

3352587

3352588

3352589

3352590

3352592

3352593

3352594

3352595

3352596

3352597

3352599

3352600

3352601

3352603

3352605

3352606

3352607

3352608

3352609

3352610

3352611

3352615

3352616

3352617

3413945

35772_at

3644723

3652090

3684189

3684338

44179_at

7944560

7944601

AB002380_at

A_14_P117429

A_14_P131096

A_23_P127642

A_24_P175783

GE54946

GO:0001664

GO:0005085

GO:0005096

GO:0005515

GO:0005737

GO:0005829

GO:0007186

GO:0007266

GO:0016020

GO:0035556

GO:0043226

GO:0051056

GO:0070062

GO:0098772

HMNXSV003038398

Hs.306461.0.S1_3p_s_at

Hs.306461.0.S1_3p_x_at

Hs.6582.0.A1_3p_a_at

Hs.6582.0.A2_3p_a_at

Hs2.374682.1.S1_3p_at

Hs2.385729.1.S1_3p_x_at

Hs2.425275.1.A1_3p_at

ILMN_1810712

ILMN_1866412

PH_hs_0024933

TC11001102.hg

g7662087_3p_a_at

g7770232_RC_3p_a_at

Participates

as a member of

as a candidate of

CDC42 GEFs [cytosol] (Homo sapiens)

as a component of

G-protein alpha (12/13):LARG [plasma membrane] (Homo sapiens)

as an input of

LARG activation by G alpha 12/13 (Homo sapiens)

Inferred To

RhoGEF2 [cytosol] (Drosophila melanogaster)

rhgf-1 [cytosol] (Caenorhabditis elegans)

arhgef12 [cytosol] (Xenopus tropicalis)

ARHGEF12 [cytosol] (Bos taurus)

ARHGEF12 [cytosol] (Canis familiaris)

ARHGEF12 [cytosol] (Gallus gallus)

ARHGEF12 [cytosol] (Sus scrofa)

Arhgef12 [cytosol] (Mus musculus)

Arhgef12 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001288013.1, XP_011541022.1, XP_016872910.1, NP_001185594.1, NP_056128.1

ENSEMBL

ENSP00000380942, ENSP00000349056, ENST00000356641, ENST00000397843

OpenTargets

ENSG00000196914

HPA

ENSG00000196914-ARHGEF12

PRO

Q9NZN5

Pharos - Targets

Q9NZN5

GlyGen

Q9NZN5

HMDB Protein

HMDBP11507

PDB

2OMJ, 1X86, 1TXD, 2OS6

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61586 RHOA	6	RHOA [plasma membrane] (R-HSA-194510) RHOA [cell junction] (R-HSA-2134503) RHOA [cytosol] (R-HSA-194866) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082)	0.77	4
UniProt:O14908 GIPC1	1	GIPC1 [cytoplasm] (R-HSA-9839329)	0.723	8
UniProt:Q9UM54 MYO6	3	MYO6 [plasma membrane] (R-HSA-3006691) MYO6 [lysosomal membrane] (R-HSA-3006694) MYO6 [cytosol] (R-HSA-3006692)	0.7	6
UniProt:P08069 IGF1R	3	p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180)	0.65	7
UniProt:Q9P0L0 VAPA	4	VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [cytosol] (R-HSA-9609920)	0.615	6
UniProt:O95292 VAPB	2	VAPB [Golgi membrane] (R-HSA-9715115) VAPB [endoplasmic reticulum membrane] (R-HSA-429718)	0.527	4
UniProt:P61793	1	LPAR1 [plasma membrane] (R-MMU-419354)	0.524	3
UniProt:Q9Q2G4 Q9Q2G4			0.462	2