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AP2M1-2 [endocytic vesicle membrane]
Stable Identifier
R-HSA-416634
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endocytic vesicle membrane
Synonyms
AP2 complex subunit mu-1, AP2M1 isoform 2
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
Trafficking of AMPA receptors (Homo sapiens)
Trafficking of GluR2-containing AMPA receptors (Homo sapiens)
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Homo sapiens)
AP2 complex [endocytic vesicle membrane] (Homo sapiens)
AP2M1-2 [endocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96CW1-2 AP2M1
Gene Names
AP2M1, CLAPM1, KIAA0109
Other Identifiers
11724231_s_at
1173
11746645_x_at
11747195_x_at
11749846_x_at
11760517_at
16948738
200613_PM_at
200613_at
2655477
2655479
2655480
2655481
2655482
2655483
2655484
2655485
2655486
2655487
2655488
2655489
2655490
2655491
2655492
2655493
2655494
2655495
2655496
2655497
2655498
2655499
2655500
2655501
2655502
2655503
2655504
2655505
2655506
2655507
2655508
2655509
2655510
2655512
2655513
39795_at
8084345
A_33_P3378800
D63475_at
GE57272
GO:0002092
GO:0005048
GO:0005515
GO:0005737
GO:0005765
GO:0005829
GO:0005886
GO:0005905
GO:0006886
GO:0006897
GO:0006900
GO:0008021
GO:0008289
GO:0009898
GO:0015031
GO:0016192
GO:0030122
GO:0030131
GO:0030666
GO:0030669
GO:0031410
GO:0031623
GO:0035615
GO:0036020
GO:0043226
GO:0044325
GO:0045202
GO:0045334
GO:0048488
GO:0050750
GO:0060090
GO:0061024
GO:0065003
GO:0070062
GO:0072583
GO:0097494
GO:0097718
GO:0098794
GO:0098884
GO:0098894
GO:0098978
GO:1900244
GO:1903077
HMNXSV003025018
ILMN_1699598
ILMN_2402798
PH_hs_0025297
TC03000994.hg
g4757993_3p_x_at
Participates
as a component of
AP2 complex [endocytic vesicle membrane] (Homo sapiens)
Inferred To
AP2M1-2 [endocytic vesicle membrane]
(Bos taurus)
AP2M1-2 [endocytic vesicle membrane]
(Canis familiaris)
AP2M1-2 [endocytic vesicle membrane]
(Drosophila melanogaster)
AP2M1-2 [endocytic vesicle membrane]
(Gallus gallus)
AP2M1-2 [endocytic vesicle membrane]
(Mus musculus)
AP2M1-2 [endocytic vesicle membrane]
(Rattus norvegicus)
AP2M1-2 [endocytic vesicle membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001298127.1
,
NP_001020376.1
,
NP_004059.2
ENSEMBL
ENSP00000292807
,
ENSP00000409081
,
ENST00000621863
,
ENSP00000371894
,
ENST00000382456
,
ENST00000292807
,
ENSP00000481563
,
ENST00000439647
OpenTargets
ENSG00000161203
HPA
ENSG00000161203-AP2M1
PRO
Q96CW1
Pharos - Targets
Q96CW1
GlyGen
Q96CW1
Orphanet
AP2M1
HMDB Protein
HMDBP14128
PDB
6URI
,
6BNT
,
1H6E
Interactors (62)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7Z3C6 ATG9A
1
ATG9A [phagophore assembly site membrane]
(R-HSA-5671732)
0.895
22
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.828
8
UniProt:P63010 AP2B1
4
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [cytosol]
(R-HSA-182166)
AP2B1 [plasma membrane]
(R-HSA-167690)
0.809
7
UniProt:Q15311 RALBP1
1
RALBP1 [cytosol]
(R-HSA-195194)
0.76
7
UniProt:Q92609 TBCD5
0.737
4
UniProt:P42566 EPS15
2
p-Y849 EPS15 [cytosol]
(R-HSA-8867028)
EPS15 [cytosol]
(R-HSA-182920)
0.725
7
UniProt:Q2M2I8 AAK1
1
AAK1 [cytosol]
(R-HSA-8854795)
0.725
6
UniProt:Q68CQ4 UTP25
1
DIEXF [nucleoplasm]
(R-HSA-6790689)
0.666
7
UniProt:Q9UHP6 RSP14
0.666
6
UniProt:P51116 FXR2
0.653
3
UniProt:P49757 NUMB
1
NUMB [plasma membrane]
(R-HSA-443595)
0.643
6
UniProt:O15084 ANKRD28
2
ANKRD28 [cytosol]
(R-HSA-5685714)
ANKRD28 [nucleoplasm]
(R-HSA-9686571)
0.643
3
UniProt:Q15811 ITSN1
1
ITSN1 [cytosol]
(R-HSA-3006481)
0.643
5
UniProt:P53680 AP2S1
4
AP2S1 [endolysosome membrane]
(R-HSA-6784821)
AP2S1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130707)
AP2S1 [cytosol]
(R-HSA-182197)
AP2S1 [plasma membrane]
(R-HSA-389382)
0.643
5
UniProt:Q8NC96 NECAP1
3
NECAP1 [cytosol]
(R-HSA-8863464)
NECAP1 [Golgi membrane]
(R-HSA-434327)
NECAP1 [cytoplasmic vesicle membrane]
(R-HSA-434218)
0.643
3
UniProt:Q9NVZ3 NECAP2
1
NECAP2 [cytosol]
(R-HSA-8863466)
0.643
5
UniProt:P29353 SHC1
5
p-Y-SHC1 [cytosol]
(R-HSA-162568)
SHC1 [cytosol]
(R-HSA-74680)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
0.643
5
UniProt:O94973 AP2A2
6
AP2A2(1-939) [endolysosome membrane]
(R-HSA-6784819)
AP2A2(1-939) [secretory granule membrane]
(R-HSA-6800412)
AP2A2(1-939) [ficolin-1-rich granule membrane]
(R-HSA-6800414)
AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138448)
AP2A2(1-939) [cytosol]
(R-HSA-182155)
AP2A2(1-939) [plasma membrane]
(R-HSA-177502)
0.643
5
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.569
9
UniProt:Q9NZ81 PRR13
0.556
3
UniProt:Q9P0T4 ZN581
0.556
3
UniProt:Q86YD7 F90A1
0.556
5
UniProt:Q1ED39 KNOP1
0.556
3
UniProt:Q99880 H2BC13
9
Ub-HIST1H2BL [nucleoplasm]
(R-HSA-6782543)
AcK-HIST1H2BL [nucleoplasm]
(R-HSA-4549254)
HIST1H2BL [extracellular region]
(R-HSA-977579)
AcK13-HIST1H2BL [nucleoplasm]
(R-HSA-4568650)
AcK16-HIST1H2BL [nucleoplasm]
(R-HSA-4568697)
AcK6-HIST1H2BL [nucleoplasm]
(R-HSA-4568719)
AcK21-HIST1H2BL [nucleoplasm]
(R-HSA-4568674)
Ub-121-HIST1H2BL [nucleoplasm]
(R-HSA-3364013)
HIST1H2BL [nucleoplasm]
(R-HSA-181920)
0.556
3
UniProt:Q9BU76 MMTAG2
3
MMTAG2 [ficolin-1-rich granule lumen]
(R-HSA-6801074)
MMTAG2 [extracellular region]
(R-HSA-6806452)
MMTAG2 [secretory granule lumen]
(R-HSA-6801073)
0.556
3
UniProt:Q03393 PTS
2
PTS [cytosol]
(R-HSA-1475061)
p-S19-PTS [cytosol]
(R-HSA-1475426)
0.556
3
UniProt:Q99633 PRPF18
1
PRPF18 [nucleoplasm]
(R-HSA-5688093)
0.556
3
UniProt:P0DPH9 CX05B
0.556
3
UniProt:Q96JC9 EAF1
1
EAF1 [nucleoplasm]
(R-HSA-8932787)
0.556
5
UniProt:Q00013 MPP1
1
MPP1 [plasma membrane]
(R-HSA-420423)
0.556
5
UniProt:P55081 MFAP1
1
MFAP1 [nucleoplasm]
(R-HSA-2396419)
0.556
3
UniProt:P62807 H2BC4
9
HIST1H2BC [nucleoplasm]
(R-HSA-181906)
Ub-121-HIST1H2BC [nucleoplasm]
(R-HSA-3364029)
AcK21-HIST1H2BC [nucleoplasm]
(R-HSA-4568626)
AcK13-HIST1H2BC [nucleoplasm]
(R-HSA-4568620)
AcK6-HIST1H2BC [nucleoplasm]
(R-HSA-4568623)
AcK16-HIST1H2BC [nucleoplasm]
(R-HSA-4568634)
HIST1H2BC [extracellular region]
(R-HSA-977564)
AcK-HIST1H2BC [nucleoplasm]
(R-HSA-4549246)
Ub-HIST1H2BC [nucleoplasm]
(R-HSA-6782552)
0.556
5
UniProt:Q8N8X9 MB213
0.556
5
UniProt:Q96EY4 TMA16
0.556
3
IntAct:EBI-16429620 CCSB ORF ID
0.556
3
UniProt:Q8N9N8 EIF1A
0.556
3
UniProt:Q6ZUT1 NKAP1
0.556
3
UniProt:Q8NAV1 PRPF38A
1
PRPF38A [nucleoplasm]
(R-HSA-8867897)
0.556
5
UniProt:Q8N3F0 MTURN
0.556
3
UniProt:Q9BSU3 NAA11
0.556
3
UniProt:P35268 RPL22
1
RPL22 [cytosol]
(R-HSA-72428)
0.556
3
UniProt:Q96MH2 HEXI2
0.556
3
UniProt:Q16778 H2BC21
9
HIST2H2BE [nucleoplasm]
(R-HSA-181908)
Ub-121-HIST2H2BE [nucleoplasm]
(R-HSA-3364018)
AcK16-HIST2H2BE [nucleoplasm]
(R-HSA-4568660)
AcK6-HIST2H2BE [nucleoplasm]
(R-HSA-4568679)
AcK21-HIST2H2BE [nucleoplasm]
(R-HSA-4568716)
AcK13-HIST2H2BE [nucleoplasm]
(R-HSA-4568651)
HIST2H2BE [extracellular region]
(R-HSA-977571)
Ack-HIST2H2BE [nucleoplasm]
(R-HSA-4549257)
Ub-HIST2H2BE [nucleoplasm]
(R-HSA-6782539)
0.556
3
UniProt:O14641 DVL2
5
DVL2 [cytosol]
(R-HSA-201694)
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.553
2
UniProt:Q59EK9 RUN3A
0.547
3
UniProt:Q77IS8 NCAP
0.544
2
UniProt:P27958-PRO_0000037566
0.543
4
UniProt:P57739 CLDN2
2
CLDN2 [plasma membrane]
(R-HSA-419994)
CLDN2 [cell junction]
(R-HSA-421235)
0.537
4
UniProt:P11274 BCR
4
BCR [cytosol]
(R-HSA-195200)
BCR(1-584)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1604524)
p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1839041)
BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1838979)
0.527
3
UniProt:O95782 AP2A1
5
AP2A1 [endolysosome membrane]
(R-HSA-6784829)
AP2A1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138449)
AP2A1 [cytosol]
(R-HSA-182143)
AP2A1 [plasma membrane]
(R-HSA-177494)
AP2A1 [endocytic vesicle membrane]
(R-HSA-416641)
0.527
4
UniProt:P0DTD1-PRO_0000449628 REP
0.527
2
UniProt:Q0JRZ9 FCHO2
1
FCHO2 [cytosol]
(R-HSA-8862260)
0.527
3
UniProt:Q10567 AP1B1
5
AP1B1 [cytoplasmic vesicle membrane]
(R-HSA-351181)
AP1B1 [Golgi membrane]
(R-HSA-350809)
AP1B1 [lysosomal membrane]
(R-HSA-432699)
AP1B1 [trans-Golgi network membrane]
(R-HSA-2130596)
AP1B1 [cytosol]
(R-HSA-167705)
0.527
4
UniProt:Q16626 MEA1
0.527
4
UniProt:P22626 HNRNPA2B1
2
HNRNPA2B1 [nucleoplasm]
(R-HSA-71929)
HNRNPA2B1 [extracellular exosome]
(R-HSA-8950304)
0.527
2
UniProt:Q9UBC2 EPS15L1
2
EPS15L1 [plasma membrane]
(R-HSA-182937)
EPS15L1 [cytosol]
(R-HSA-8935900)
0.527
4
UniProt:Q96D71 REPS1
1
REPS1 [cytosol]
(R-HSA-8862265)
0.527
4
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P18272 NCAP
0.524
2
UniProt:Q01968 OCRL
4
OCRL [Golgi membrane]
(R-HSA-434339)
OCRL [cytoplasmic vesicle membrane]
(R-HSA-434214)
OCRL [plasma membrane]
(R-HSA-3769049)
OCRL [cytosol]
(R-HSA-1806196)
0.508
3
UniProt:P51114 FXR1
2
FXR1(2-784)-BRAF(381-766) fusion [cytosol]
(R-HSA-6802326)
FXR1(2-784)-p-BRAF(381-766) fusion [cytosol]
(R-HSA-6802530)
0.508
2
UniProt:A9UF07 A9UF07
0.462
2
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