Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites

Stable Identifier
R-HSA-416639
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites
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GluR2 containing AMPA receptors are trafficked to the plasmamembrane by the activation of Ca activated PKC that binds PICK.The PICK interaction delivers GluR2 containing AMPA receptors to the Plasmamembrane. This reaction is a part of constitutive recycling of AMPA receptor that delivers the AMPA receptors from the endosome to the plasmamembrane and back to endosome from the plasmamembrane.

Literature References
PubMed ID Title Journal Year
16055064 PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking

Lu, W, Ziff, EB

Neuron 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

calcium-dependent protein kinase C activity of Activated conventional protein kinase C [plasma membrane]

Physical Entity
Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
Activity
calcium-dependent protein kinase C activity (GO:0004698)
Orthologous Events
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Canis familiaris)
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Danio rerio)
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Gallus gallus)
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Mus musculus)
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Rattus norvegicus)
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Sus scrofa)
Authored
Mahajan, SS  (2008-01-14)
Reviewed
Ziff, EB  (2009-05-15)
Created
Mahajan, SS  (2009-03-30)
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