Reactome | AP2B1-1 [endocytic vesicle membrane]

AP2B1-1 [endocytic vesicle membrane]

Stable Identifier

R-HSA-416642

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endocytic vesicle membrane

Synonyms

AP2 complex subunit beta-1

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
      - Trafficking of AMPA receptors (Homo sapiens)
        
        Trafficking of GluR2-containing AMPA receptors (Homo sapiens)
        
        Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Homo sapiens)
        
        AP2 complex [endocytic vesicle membrane] (Homo sapiens)
        
        AP2B1-1 [endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P63010-1 AP2B1

Gene Names

AP2B1, ADTB2, CLAPB1

Other Identifiers

11716261_a_at

11716262_a_at

163

16833345

200612_PM_s_at

200612_s_at

200615_PM_s_at

200615_s_at

36161_at

3718683

3718684

3718686

3718696

3718700

3718703

3718706

3718707

3718708

3718709

3718710

3718712

3718713

3718714

3718715

3718717

3718718

3718721

3718722

3718723

3718724

3718725

3718730

3718732

3718735

3718739

3718740

3718741

4014722

4014723

4014724

4014729

4014731

4014733

4014735

4014738

8006542

A_23_P55149

A_24_P253827

GE57939

GO:0001822

GO:0003279

GO:0003281

GO:0005048

GO:0005515

GO:0005764

GO:0005768

GO:0005773

GO:0005829

GO:0005886

GO:0005905

GO:0006886

GO:0006897

GO:0007507

GO:0009898

GO:0015031

GO:0016020

GO:0016192

GO:0030117

GO:0030122

GO:0030131

GO:0030276

GO:0030666

GO:0030669

GO:0031090

GO:0031410

GO:0035615

GO:0035904

GO:0036020

GO:0043226

GO:0045202

GO:0045334

GO:0048488

GO:0048856

GO:0060090

GO:0060976

GO:0072583

GO:0098793

GO:0098794

GO:0098884

GO:0098978

GO:0099590

HMNXSV003043367

Hs.74626.0.A1_3p_s_at

ILMN_1681998

ILMN_2331735

M34175_at

PH_hs_0024131

TC17000399.hg

g4557468_3p_a_at

Participates

as a component of

AP2 complex [endocytic vesicle membrane] (Homo sapiens)

Inferred To

AP2B1-1 [endocytic vesicle membrane] (Gallus gallus)

AP2B1-1 [endocytic vesicle membrane] (Sus scrofa)

AP-1-2beta [endocytic vesicle membrane] (Drosophila melanogaster)

AP2B1 [endocytic vesicle membrane] (Bos taurus)

AP2B1 [endocytic vesicle membrane] (Canis familiaris)

Ap2b1 [endocytic vesicle membrane] (Mus musculus)

Ap2b1 [endocytic vesicle membrane] (Rattus norvegicus)

Cross References

RefSeq

XP_016879773.1, XP_005257994.1, NP_001273.1, XP_011522757.1, NP_001025177.1, XP_016879775.1, XP_005257995.1

OpenTargets

ENSG00000006125

HPA

ENSG00000006125-AP2B1

GeneCards

P63010

Ensembl

ENST00000618940, ENSP00000482835, ENSP00000482315, ENSP00000483185, ENSG00000006125, ENST00000621914, ENST00000610402

PRO

P63010

Pharos - Targets

P63010

PDB

6QH7, 7OG1, 6YAH, 6QH6, 7OM8, 7OHO, 6QH5, 6YAE, 6URI, 7Z5C, 2VGL, 2IV8, 2JKR, 6YAF, 2IV9, 2JKT, 6YAI, 5M5R, 2XA7, 1E42, 2G30, 4UQI

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.809	7
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.764	5
UniProt:Q5SW96 LDLRAP1	2	LDLRAP1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869097) LDLRAP1 [plasma membrane] (R-HSA-171143)	0.681	4
UniProt:P12236 SLC25A6	2	SLC25A6 [mitochondrial inner membrane] (R-HSA-49745) SLC25A6 [mitochondrial intermembrane space] (R-HSA-1955374)	0.666	4
UniProt:Q2M2I8 AAK1	1	AAK1 [cytosol] (R-HSA-8854795)	0.643	3
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.643	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.569	5
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:Q9UHB7 AFF4	1	AFF4 [nucleoplasm] (R-HSA-8932788)	0.556	3
UniProt:Q96D71 REPS1	1	REPS1 [cytosol] (R-HSA-8862265)	0.527	3
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.527	4
UniProt:Q9UBC2 EPS15L1	2	EPS15L1 [plasma membrane] (R-HSA-182937) EPS15L1 [cytosol] (R-HSA-8935900)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.527	3

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