Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Other semaphorin interactions
Stable Identifier
R-HSA-416700
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Other semaphorin interactions (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this pathway in the Pathway Browser
There are eight classes of semaphorins and four types of plexins. Semaphorin (SEMA) classes 1 and 2 are found in invertebrates and classes 3-7 are vertebrate sempahorines. Sempahorin class 3 is secreted, whereas the other classes are synthesised as transmembrane proteins. Vertebrate plexins (PLXNs) are classified into four subfamilies plexin-A to -D. There are four A-type plexins, three B-type, one C-type and D-type. Interactions between different subfamilies of plexins and semaphorins show differential specificity, which trigger different sets of biological functions. Another level of functional specificity specificity is attained by plexins by coupling with various coreceptors expressed in a cell- or tissue-specific manner, such as neuropilins (NRP), L1CAM, c-MET proto-oncogene, ERB2, CD72 and CD45 (Kruger et al. 2005, Law & Lee 2012).
Participants
Events
SEMA3E binds to PLXND1
(Homo sapiens)
SEMA4A binds to PLXND1
(Homo sapiens)
SEMA4D interacts with CD45
(Homo sapiens)
SEMA4D interacts with CD72
(Homo sapiens)
SEMA5A binds to PLXNB3
(Homo sapiens)
SEMA6A binds to PLXNA2 and PLXNA4
(Homo sapiens)
SEMA6D binds to PLXNA1:TREM2:DAP12
(Homo sapiens)
SEMA7A binds to PLXNC1
(Homo sapiens)
SEMA7A binds to integrin alpha1beta1
(Homo sapiens)
Participates
as an event of
Semaphorin interactions (Homo sapiens)
Orthologous Events
Other semaphorin interactions (Bos taurus)
Other semaphorin interactions (Caenorhabditis elegans)
Other semaphorin interactions (Canis familiaris)
Other semaphorin interactions (Danio rerio)
Other semaphorin interactions (Drosophila melanogaster)
Other semaphorin interactions (Gallus gallus)
Other semaphorin interactions (Mus musculus)
Other semaphorin interactions (Rattus norvegicus)
Other semaphorin interactions (Sus scrofa)
Other semaphorin interactions (Xenopus tropicalis)
Authored
Garapati, P V (2009-03-23)
Reviewed
Kikutani, H (2009-09-02)
Kumanogoh, A (2009-09-02)
Created
Garapati, P V (2009-03-31)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text