Reactome | COPS2 [cytosol]

COPS2 [cytosol]

Stable Identifier

R-HSA-416971

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

COP9 signalosome complex subunit 2, CSN2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOBTB GTPase Cycle (Homo sapiens)
        
        RHOBTB1 GTPase cycle (Homo sapiens)
        
        RHOBTB1 binds interacting proteins at the endosome membrane (Homo sapiens)
        
        RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
        
        COPS2 [cytosol] (Homo sapiens)
        
        RHOBTB1:GTP:RHOBTB1 interacting proteins [endosome membrane] (Homo sapiens)
        
        RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
        
        COPS2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61201 COPS2

Gene Names

COPS2, CSN2, TRIP15

Chain

chain:1-443

Reference Genes

BioGPS Gene:9318 COPS2

COSMIC (genes):COPS2 COPS2

CTD Gene:9318 COPS2

dbSNP Gene:9318 COPS2

ENSEMBL:ENSG00000166200 COPS2

ENSEMBL_homo_sapiens_GENE:ENSG00000166200.15 COPS2

HGNC:30747 COPS2

KEGG Gene (Homo sapiens):9318 COPS2

Monarch:9318 COPS2

NCBI Gene:9318 COPS2

OMIM:604508 COPS2

UCSC:P61201 COPS2

Reference Transcript

Other Identifiers

11724191_a_at

11724192_at

11724193_s_at

16808974

202467_PM_s_at

202467_s_at

209838_PM_at

209838_at

248_at

2916770

34323_at

3623414

3623425

3623426

3623427

3623428

3623429

3623430

3623431

3623432

3623433

3623435

3623437

3623438

3623440

3623441

3623442

3623443

3623444

3623445

3623446

3623447

3623448

44304_at

53780_s_at

53783_r_at

65584_at

7988605

9318

A_23_P26021

GE54739

GO:0000122

GO:0000338

GO:0001833

GO:0001834

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006366

GO:0006468

GO:0007165

GO:0008180

GO:0023052

GO:0030154

GO:0030182

GO:0032991

GO:0035914

GO:0036211

GO:0043226

GO:0045116

GO:0045892

GO:0048856

GO:0140110

GO:2000434

HMNXSV003008260

Hs.30212.1.S2_3p_at

Hs.30212.2.S1_3p_a_at

Hs.30212.2.S1_3p_x_at

ILMN_1655827

L40388_at

PH_hs_0002595

PH_hs_0035410

TC15001342.hg

g4759263_3p_a_at

Participates

as a candidate of

RHOBTB1 interacting proteins [cytosol] (Homo sapiens)

as a component of

COP9 [cytosol] (Homo sapiens)

Other forms of this molecule

COPS2 [nucleoplasm]

Inferred To

csn2 [cytosol] (Dictyostelium discoideum)

Cops2 [cytosol] (Mus musculus)

Cops2 [cytosol] (Rattus norvegicus)

COPS2 [cytosol] (Bos taurus)

COPS2 [cytosol] (Canis familiaris)

COPS2 [cytosol] (Gallus gallus)

COPS2 [cytosol] (Sus scrofa)

csn-2 [cytosol] (Caenorhabditis elegans)

cops2 [cytosol] (Danio rerio)

cops2 [cytosol] (Xenopus tropicalis)

alien [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001137359.1, NP_004227.1

OpenTargets

ENSG00000166200

HPA

ENSG00000166200-COPS2

GeneCards

P61201

Ensembl

ENST00000299259, ENST00000388901, ENSP00000299259, ENSP00000373553, ENSG00000166200

PRO

P61201

Pharos - Targets

P61201

PDB

8H3A, 6R7I, 6R6H, 4D10, 8H38, 6R7F, 4WSN, 6R7H, 4D18, 6R7N, 6A73, 8H3F

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.558	2
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P49821 NDUFV1	1	NDUFV1 [mitochondrial inner membrane] (R-HSA-163926)	0.556	3
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.527	2
UniProt:P45481 Crebbp	4	CREBBP [nucleoplasm] (R-MMU-193545) Crebbp [nucleoplasm] (R-MMU-556795) Foxo4-S-S-Crebbp [nucleoplasm] (R-MMU-9617719) monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm] (R-MMU-3927936)	0.527	2
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.462	6