Reactome | GPS1 [cytosol]

GPS1 [cytosol]

Stable Identifier

R-HSA-416972

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

COP9 signalosome complex subunit 1, CSN1_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOBTB GTPase Cycle (Homo sapiens)
        
        RHOBTB1 GTPase cycle (Homo sapiens)
        
        RHOBTB1 binds interacting proteins at the endosome membrane (Homo sapiens)
        
        RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
        
        GPS1 [cytosol] (Homo sapiens)
        
        RHOBTB1:GTP:RHOBTB1 interacting proteins [endosome membrane] (Homo sapiens)
        
        RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
        
        GPS1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13098 GPS1

Gene Names

GPS1, COPS1, CSN1

Chain

initiator methionine:, chain:2-491

Reference Genes

BioGPS Gene:2873 GPS1

COSMIC (genes):GPS1 GPS1

CTD Gene:2873 GPS1

dbSNP Gene:2873 GPS1

ENSEMBL:ENSG00000169727 GPS1

HGNC:4549 GPS1

KEGG:hsa:2873 GPS1

Monarch:2873 GPS1

NCBI Gene:2873 GPS1

OMIM:601934 GPS1

UCSC:Q13098 GPS1

Reference Transcript

Other Identifiers

11715535_a_at

16838988

217782_3p_s_at

217782_PM_s_at

217782_s_at

2873

3738491

3738493

3738494

3738495

3738496

3738497

3738498

3738499

3738500

3738501

3738502

3738503

3738504

3738505

3738506

3738507

3738508

3738509

3738510

3738511

3738512

3738513

3738514

3738515

3738516

3738517

3738518

3738519

3738520

3738521

3738522

3738523

3738524

73190_at

78787_at

8010747

A_14_P128722

A_23_P158662

GE62727

GO:0000338

GO:0005095

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0007254

GO:0008180

GO:0032991

GO:0043226

GO:0045116

GO:0098772

GO:2000434

HMNXSV003008519

ILMN_1769960

ILMN_1795876

ILMN_2309228

PH_hs_0026722

TC17000945.hg

U20285_at

g13435380_3p_a_at

g13435380_3p_at

g13435380_3p_x_at

Participates

as a candidate of

RHOBTB1 interacting proteins [cytosol] (Homo sapiens)

as a component of

COP9 [cytosol] (Homo sapiens)

Other forms of this molecule

GPS1 [nucleoplasm]

Inferred To

GPS1 [cytosol] (Bos taurus)

GPS1 [cytosol] (Canis familiaris)

GPS1 [cytosol] (Gallus gallus)

GPS1 [cytosol] (Sus scrofa)

CSN1b [cytosol] (Drosophila melanogaster)

csn1 [cytosol] (Dictyostelium discoideum)

Gps1 [cytosol] (Mus musculus)

Gps1 [cytosol] (Rattus norvegicus)

Ghost homologue of GPS1 [cytosol] (Danio rerio)

csn-1 [cytosol] (Caenorhabditis elegans)

gps1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_016880023.1, NP_004118.3, NP_997657.1, NP_001308021.1

ENSEMBL

ENST00000306823, ENST00000578552, ENSP00000302873, ENSP00000462265, ENST00000392358, ENSP00000376167

OpenTargets

ENSG00000169727

HPA

ENSG00000169727-GPS1

PRO

Q13098

Pharos - Targets

Q13098

GlyGen

Q13098

PDB

4D10, 4D18, 8H3F, 6R7F, 6R7N, 6R7H, 8H3A, 8H38, 4WSN, 6R6H, 6R7I

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.592	6
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.527	2
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.462	5