Trafficking of GluR2-containing AMPA receptors to synapse

Stable Identifier
R-HSA-416985
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Constitutively recycling GluR2 containing AMPA receptors in the plasma membrane are stabilized by the action of NSF ATPase activity which disassociates PICK from GluR2 thereby retaining AMPA receptors in the plasma membrane.

Literature References
PubMed ID Title Journal Year
16055064 PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking

Lu, W, Ziff, EB

Neuron 2005
Participants
Participates
Catalyst Activity

ATPase activity of NSF [cytosol]

This event is regulated
Negatively by
Regulator
Summation

Tetraspanin 7 (TSPAN7) a member of the tetraspanin superfamily associates dynamically with numerous partner proteins in tetraspanin-enriched microdomains (TEMs) of the plasma membrane (Boucheix and Rubinstein, 2001). TSPAN7 promotes filopodia and dendritic spine formation in cultured hippocampal neurons, and is required for spine stability and normal synaptic transmission. Via its C-terminus, TSPAN7 interacts with the PDZ domain of protein interacting with C kinase 1 (PICK1), to regulate PICK1 and GluR2/3 association and AMPA receptor trafficking (Bassani et al. 2012). PICK1 is involved in the internalization and recycling of AMPA receptors (AMPARs) (Perez et al. 2001). In hippocampal neurons, TSPAN7 may regulate AMPA receptor trafficking by limiting PICK1 accessibility to AMPA receptors and suggest an additional mechanism for the functional maturation of glutamatergic synapses, whose impairment is implicated in intellectual disability (Bassani et al. 2012).

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