Reactome | p-T287-CAMK2B [endocytic vesicle membrane]

p-T287-CAMK2B [endocytic vesicle membrane]

Stable Identifier

R-HSA-417009

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endocytic vesicle membrane

Synonyms

Ca/Calmodulin dependent protein kinase II beta subunit

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
      - Trafficking of AMPA receptors (Homo sapiens)
        
        Trafficking of GluR1-containing AMPA receptors (Homo sapiens)
        
        CaMKII [endocytic vesicle membrane] (Homo sapiens)
        
        CaMKII subunits alpha/beta [endocytic vesicle membrane] (Homo sapiens)
        
        p-T287-CAMK2B [endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13554 CAMK2B

Gene Names

CAMK2B, CAM2, CAMK2, CAMKB

Chain

chain:1-666

Reference Genes

BioGPS Gene:816 CAMK2B

COSMIC (genes):CAMK2B CAMK2B

CTD Gene:816 CAMK2B

dbSNP Gene:816 CAMK2B

ENSEMBL:ENSG00000058404 CAMK2B

HGNC:1461 CAMK2B

KEGG:hsa:816 CAMK2B

Monarch:816 CAMK2B

NCBI Gene:816 CAMK2B

OMIM:607707 CAMK2B

UCSC:Q13554 CAMK2B

Reference Transcript

Participates

as a member of

CaMKII subunits alpha/beta [endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

p-T287-CAMK2B [cytosol]

CAMK2B [cytosol]

p-T287-CAMK2B [nucleoplasm]

p-T287-CAMK2B [plasma membrane]

Inferred To

phospho-CAMK2B [endocytic vesicle membrane] (Canis familiaris)

phospho-p-T287-CAMK2B [endocytic vesicle membrane] (Bos taurus)

phospho-p-T287-CAMK2B [endocytic vesicle membrane] (Mus musculus)

phospho-p-T287-CAMK2B [endocytic vesicle membrane] (Rattus norvegicus)

phospho-p-T287-CAMK2B [endocytic vesicle membrane] (Sus scrofa)

Modified Residues

Name

O-phospho-L-threonine at 287

Coordinate

287

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_742081.1, NP_001211.3, NP_742080.1, NP_742075.1, NP_001280099.1, NP_742078.1, NP_742076.1, NP_742079.1, NP_742077.1

Guide to Pharmacology - Targets

1556

OpenTargets

ENSG00000058404

ENSEMBL

ENSP00000258682, ENSP00000326518, ENSP00000326427, ENST00000346990, ENST00000395747, ENST00000395749, ENST00000358707, ENST00000353625, ENSP00000379098, ENST00000258682, ENSP00000326544, ENSP00000514918, ENST00000700285, ENST00000350811, ENSG00000058404, ENSP00000379096, ENST00000440254, ENST00000347193, ENSP00000326375, ENSP00000351542, ENSP00000397937

ZINC - FDA approved

KCC2B_HUMAN

ZINC - Substances

KCC2B_HUMAN

ZINC - Biogenic

KCC2B_HUMAN

ZINC target

Q13554

PRO

Q13554

GlyGen

Q13554

PDB

7URW, 3BHH, 7URZ, 7URY

ZINC - Investigational

KCC2B_HUMAN

ZINC - Metabolites

KCC2B_HUMAN

HPA

ENSG00000058404-CAMK2B

GeneCards

CAMK2B

Pharos - Targets

Q13554

Orphanet

CAMK2B

ZINC - Predictions - Purchasable

KCC2B_HUMAN

HMDB Protein

HMDBP14189

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.556	3
UniProt:Q8N0Z6 TTC5	3	p-S203,S221-TTC5 [nucleoplasm] (R-HSA-6804259) p-S203-TTC5 [nucleoplasm] (R-HSA-6804261) TTC5 [nucleoplasm] (R-HSA-6804264)	0.556	3
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2

Cite Us!