Reactome | ASF1A [nucleoplasm]

ASF1A [nucleoplasm]

Stable Identifier

R-HSA-417169

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone chaperone ASF1A, ASF1A_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q13112 CAF1B

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular Senescence (Homo sapiens)
    - DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
      - Formation of Senescence-Associated Heterochromatin Foci (SAHF) (Homo sapiens)
        
        Initiation of SAHF formation (Homo sapiens)
        
        ASF1A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y294 ASF1A

Gene Names

ASF1A, CGI-98, HSPC146

Chain

chain:1-204

Reference Genes

BioGPS Gene:25842 ASF1A

COSMIC (genes):ASF1A ASF1A

CTD Gene:25842 ASF1A

dbSNP Gene:25842 ASF1A

ENSEMBL:ENSG00000111875 ASF1A

HGNC:20995 ASF1A

KEGG:hsa:25842 ASF1A

Monarch:25842 ASF1A

NCBI Gene:25842 ASF1A

OMIM:609189 ASF1A

UCSC:Q9Y294 ASF1A

Reference Transcript

RefSeq:NM_014034.2 ASF1A

Other Identifiers

11720788_at

11720789_at

11720790_s_at

17012108

203427_PM_at

203427_at

203428_PM_s_at

203428_s_at

25842

2923361

2923362

2923363

2923365

2923366

2923367

2923368

39806_at

8121734

A_23_P19219

GE79712

GO:0000785

GO:0001649

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006281

GO:0006325

GO:0006334

GO:0006335

GO:0006974

GO:0030154

GO:0031297

GO:0032991

GO:0035861

GO:0042393

GO:0042692

GO:0043226

GO:0065003

GO:0140104

GO:0140713

GO:0140861

HMNXSV003042988

ILMN_1714737

PH_hs_0023538

TC06000937.hg

g7661591_3p_at

g8439508_3p_a_at

Participates

as a component of

HIRA:ASF1A:UBN1:CABIN1 [nucleoplasm] (Homo sapiens)

as an input of

Initiation of SAHF formation (Homo sapiens)

Inferred To

ASF1 [nucleoplasm] (Gallus gallus)

ASF1 [nucleoplasm] (Saccharomyces cerevisiae)

asf1 [nucleoplasm] (Dictyostelium discoideum)

asf1 [nucleoplasm] (Drosophila melanogaster)

Asf1a [nucleoplasm] (Mus musculus)

Asf1a [nucleoplasm] (Rattus norvegicus)

cia1 [nucleoplasm] (Schizosaccharomyces pombe)

asf1a [nucleoplasm] (Xenopus tropicalis)

unc-85 [nucleoplasm] (Caenorhabditis elegans)

ASF1A [nucleoplasm] (Bos taurus)

ASF1A [nucleoplasm] (Canis familiaris)

ASF1A [nucleoplasm] (Plasmodium falciparum)

ASF1A [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_054753.1

OpenTargets

ENSG00000111875

ENSEMBL

ENST00000229595, ENSP00000229595

HPA

ENSG00000111875-ASF1A

ZINC - Substances

ASF1A_HUMAN

ZINC target

Q9Y294

PRO

Q9Y294

Pharos - Targets

Q9Y294

GlyGen

Q9Y294

ZINC - Predictions - Purchasable

ASF1A_HUMAN

PDB

2IO5, 8CJ3, 7LO0, 2IIJ, 7LNY, 6F0H, 5C3I, 2I32, 3AAD, 7V6Q, 6ZUF, 1TEY, 6F0G, 8BV1, 8CJ1, 6F0F, 8CJ2

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.954	17
UniProt:P54198 HIRA	1	HIRA [nucleoplasm] (R-HSA-2532790)	0.902	16
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Me1K5-H3C1 [nucleoplasm] (R-HSA-9677683) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135)	0.894	11
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.89	12
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.788	6
UniProt:Q86UE8 TLK2			0.741	10
UniProt:Q9Y6J0 CABIN1	1	CABIN1 [nucleoplasm] (R-HSA-3878125)	0.725	5
UniProt:Q8IWY9 CDAN1			0.725	6
UniProt:Q9Y2V0 CDIN1			0.725	5
UniProt:P62799 H4			0.724	5
UniProt:P79522 PRR3			0.718	6
UniProt:Q13112 CAF1B			0.656	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.647	4
UniProt:Q9NPG3 UBN1	1	UBN1 [nucleoplasm] (R-HSA-2532791)	0.643	7
UniProt:Q96HA7 TONSL			0.643	4
UniProt:Q6ZU65 UBN2			0.643	4
UniProt:O14929 HAT1	1	HAT1 [nucleoplasm] (R-HSA-3662337)	0.643	4
UniProt:P49321 NASP			0.643	5
UniProt:P84233 Unknown	2	Histone H3.2 [nucleoplasm] (R-XLA-4549227) Ack15-histone H3.2 [nucleoplasm] (R-XLA-4549248)	0.632	4
UniProt:P84243 H3-3A	18	H3F3A [nucleoplasm] (R-HSA-212295) Me2K5-H3F3A [nucleoplasm] (R-HSA-1214206) Me3K-28-H3F3A [nucleoplasm] (R-HSA-212282) Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625747) p-T12,Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625758) p-T12, Me2K-10-H3F3A [nucleoplasm] (R-HSA-5625800) p-T12,MeK-H3F3A [nucleoplasm] (R-HSA-5625858) p-T12-H3F3A [nucleoplasm] (R-HSA-5625878) Me2K-10-H3F3A [nucleoplasm] (R-HSA-427324) Me3K5-H3F3A [nucleoplasm] (R-HSA-1214216) H3F3A [extracellular region] (R-HSA-977567) AcK10-H3F3A [nucleoplasm] (R-HSA-5250654) Me2K5,Me2aR2-H3F3A [nucleoplasm] (R-HSA-8936573) H3R17me2a [nucleoplasm] (R-HSA-9822613) MeK28-H3-3A [nucleoplasm] (R-HSA-9822942) Me1K5-H3-3A [nucleoplasm] (R-HSA-9864864) 2xAcK-H3F3A [nucleoplasm] (R-HSA-427504) MeK-H3F3A [nucleoplasm] (R-HSA-427369)	0.597	5
UniProt:Q71DI3 H3C15	20	2xAcK-HIST2H3A [nucleoplasm] (R-HSA-427525) Me1K5-HIST2H3A [nucleoplasm] (R-HSA-9677679) Me2aR27-HIST2H3A [nucleoplasm] (R-HSA-5229057) Me2aR18-HIST2H3A [nucleoplasm] (R-HSA-5229063) Me2sR9-HIST2H3A [nucleoplasm] (R-HSA-5211327) Me2sR3-HIST2H3A [nucleoplasm] (R-HSA-5218930) AcK9,14-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8870892) AcK14,18,79-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871273) AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871304) AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871292) AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8865607) AcK14,18-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871296) AcK14,18,79-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871290) AcK14,18-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871302) AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871289) Me2K28-HIST2H3A [nucleoplasm] (R-HSA-4754197) MeK37-HIST2H3A [nucleoplasm] (R-HSA-4722131) MeK80-HIST2H3A [nucleoplasm] (R-HSA-5649805) Me3K80-HIST2H3A [nucleoplasm] (R-HSA-5649798) Me2K80-HIST2H3A [nucleoplasm] (R-HSA-5649803)	0.576	4
UniProt:P02309	14	HHF2 [nucleoplasm] (R-SCE-181902) HHF2 [nucleoplasm] (R-SCE-5651652) HHF2 [nucleoplasm] (R-SCE-5423110) HHF2 [nucleoplasm] (R-SCE-3451124) HHF2 [nucleoplasm] (R-SCE-4568758) HHF2 [nucleoplasm] (R-SCE-4568748) HHF2 [nucleoplasm] (R-SCE-427469) HHF2 [nucleoplasm] (R-SCE-5651656) HHF2 [nucleoplasm] (R-SCE-4754240) HHF2 [nucleoplasm] (R-SCE-4754243) HHF2 [nucleoplasm] (R-SCE-5229015) HHF2 [nucleoplasm] (R-SCE-4568744) HHF2 [nucleoplasm] (R-SCE-212078) HHF2 [nucleoplasm] (R-SCE-4570518)	0.556	3
UniProt:Q12161 PSH1			0.556	3
UniProt:P49321-2 NASP			0.556	3
UniProt:Q9UKI8 TLK1			0.547	3
UniProt:Q5UIP0 RIF1	1	RIF1 [nucleoplasm] (R-HSA-480742)	0.527	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.527	3
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.527	3
UniProt:Q14566 MCM6	1	MCM6 [nucleoplasm] (R-HSA-68553)	0.527	3
UniProt:P33991 MCM4	1	MCM4 [nucleoplasm] (R-HSA-68549)	0.527	3
UniProt:Q9NVP2 ASF1B			0.527	2
UniProt:Q5UIP0-2 RIF1			0.527	2
UniProt:Q9NPG3-2 UBN1			0.527	2
UniProt:Q8NI37 PPTC7			0.527	3
UniProt:Q86UE8-2 TLK2			0.527	2
UniProt:Q8TEX9 IPO4			0.527	3
UniProt:Q58A45 PAN3	1	PAN3 [cytosol] (R-HSA-429938)	0.527	3

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