Reactome | P2RY12 binds ADP

P2RY12 binds ADP

Stable Identifier

R-HSA-417829

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Nucleotide-like (purinergic) receptors (Homo sapiens)
        
        P2Y receptors (Homo sapiens)
        
        P2RY12 binds ADP (Homo sapiens)

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P2RY12 (Bodor et al. 2003) is found on the surface of blood platelet cells and is an important regulator in blood clotting. It is one of two ADP receptors expressed in platelets, the other is P2RY1. Activation leads to irreversible platelet aggregation. Defects in this receptor are associated with bleeding disorders. Its preferred ligand is ADP. The platelet anticoagulant drug clopidogrel binds to this receptor (Hollopeter G et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
12560222	Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270 Kim, S, Dorsam, RT, Ding, Z, Jin, J, Kunapuli, SP	Blood	2003
14573771	Purification and functional reconstitution of the human P2Y12 receptor Hooks, SB, Boyer, JL, Bodor, ET, Waldo, GL, Harden, TK, Corbitt, J	Mol Pharmacol	2003
11196645	Identification of the platelet ADP receptor targeted by antithrombotic drugs Vincent, D, Conley, PB, Yang, RB, Jantzen, HM, England, L, Li, G, Julius, D, Ramakrishnan, V, Nurden, A, Nurden, P, Hollopeter, G	Nature	2001