Reactome | P2RY6 [plasma membrane]

P2RY6 [plasma membrane]

Stable Identifier

R-HSA-417924

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

P2Y purinoceptor 6, P2RY6_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P55060 XPO2

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External Reference Information

External Reference

UniProt:Q15077 P2RY6

Gene Names

P2RY6, PP2891

Chain

chain:1-328

Reference Genes

BioGPS Gene:5031 P2RY6

COSMIC (genes):P2RY6 P2RY6

CTD Gene:5031 P2RY6

dbSNP Gene:5031 P2RY6

ENSEMBL:ENSG00000171631 P2RY6

ENSEMBL_homo_sapiens_GENE:ENSG00000171631.16 P2RY6

HGNC:8543 P2RY6

KEGG Gene (Homo sapiens):5031 P2RY6

Monarch:5031 P2RY6

NCBI Gene:5031 P2RY6

OMIM:602451 P2RY6

UCSC:Q15077 P2RY6

Reference Transcript

Other Identifiers

11725227_at

11725228_a_at

16728788

208373_PM_s_at

208373_s_at

2406606

3339775

3339776

3339777

3339778

3339779

3339780

3339781

3339785

3339786

3339789

3339790

3339791

3339792

3339805

3339807

3339809

3339811

3339813

3339814

3339815

3339816

3339817

3339818

3339819

3339820

3339821

38222_at

5031

68778_at

7942409

A_14_P139568

A_14_P200317

A_23_P64611

A_24_P196413

GE54091

GO:0001621

GO:0004930

GO:0005515

GO:0005886

GO:0005975

GO:0006909

GO:0007165

GO:0007186

GO:0007200

GO:0007202

GO:0014911

GO:0016020

GO:0016192

GO:0016323

GO:0016324

GO:0023052

GO:0030321

GO:0031587

GO:0032962

GO:0035589

GO:0045028

GO:0045029

GO:0045030

GO:0048870

GO:0055065

GO:0055085

GO:0060089

GO:0070374

GO:0071380

GO:0071407

GO:0071415

GO:1904707

GO:1905835

HMNXSV003033364

ILMN_1660031

ILMN_1782275

ILMN_1790029

ILMN_1838154

PH_hs_0001515

PH_hs_0010413

TC11000773.hg

TC11002781.hg

X97058_at

g4758863_3p_a_at

Participates

as an input of

P2Y6 receptor can bind to UDP (Homo sapiens)

as a member of

GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)

as a component of

P2RY6:UDP [plasma membrane] (Homo sapiens)

Inferred To

P2RY3 [plasma membrane] (Gallus gallus)

P2RY6 [plasma membrane] (Bos taurus)

P2RY6 [plasma membrane] (Canis familiaris)

P2RY6 [plasma membrane] (Sus scrofa)

P2ry6 [plasma membrane] (Mus musculus)

P2ry6 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001264137.1, XP_011543381.1, NP_789766.1, NP_001264135.1, XP_006718634.1, NP_001264133.1, XP_011543379.1, NP_001264136.1, NP_789767.1, NP_001264134.1, XP_005274079.1, NP_789768.1

Guide to Pharmacology - Targets

326

OpenTargets

ENSG00000171631

ZINC - Substances

P2RY6_HUMAN

ZINC target

Q15077

ZINC - Biogenic

P2RY6_HUMAN

PRO

Q15077

ZINC - Investigational

P2RY6_HUMAN

ZINC - Metabolites

P2RY6_HUMAN

HPA

ENSG00000171631-P2RY6

GeneCards

Q15077

Ensembl

ENST00000538328, ENSP00000377215, ENST00000540124, ENST00000540342, ENST00000349767, ENST00000618468, ENSP00000440770, ENST00000535931, ENSP00000445652, ENST00000679753, ENST00000680955, ENSP00000480966, ENSP00000441079, ENSG00000171631, ENSP00000442990, ENSP00000442551, ENSP00000505646, ENSP00000504879, ENST00000544437, ENST00000393590, ENST00000393592, ENST00000393591, ENSP00000443427, ENSP00000377216, ENSP00000377217, ENSP00000309771, ENST00000542092

Pharos - Targets

Q15077

ZINC - Predictions - Purchasable

P2RY6_HUMAN

HMDB Protein

HMDBP07861

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:O15162 PLS1			0.556	3
UniProt:Q8NI22 MCFD2	3	MCFD2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689836) MCFD2 [ER to Golgi transport vesicle membrane] (R-HSA-1017216) MCFD2 [endoplasmic reticulum membrane] (R-HSA-5689470)	0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:Q9BYR6 KRTAP3-3	1	KRTAP3-3 [cytosol] (R-HSA-6809859)	0.556	3
UniProt:Q9BYQ4 KRTAP9-2	1	KRTAP9-2 [cytosol] (R-HSA-6809965)	0.556	5
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	5
UniProt:P60328 KRTAP12-3	1	KRTAP12-3 [cytosol] (R-HSA-6810284)	0.556	3
UniProt:Q9BYR9 KRTAP2-4	1	KRTAP2-4 [cytosol] (R-HSA-6809951)	0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:P55060 XPO2			0.499	2
UniProt:Q14974 KPNB1	5	KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [cytosol] (R-HSA-180733)	0.499	4

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