F2R:ARRB1 binds MAPKs, SRC-1

Stable Identifier
R-HSA-418170
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Synonyms
Beta-arrestin-1 acts as scaffold for a PAR1 signalling complex
ReviewStatus
5/5
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F2R:ARRB1 binds MAPKs, SRC-1
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Beta-arrestins can serve as scaffolding molecules that facilitate G-protein independent cell signaling
Literature References
PubMed ID Title Journal Year
9924018 Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

Kawakatsu, H, Luttrell, LM, Ferguson, SS, Owada, K, Caron, MG, Lefkowitz, RJ, Lin, F, Maudsley, S, Miller, WE, Luttrell, DK, Della Rocca, GJ, Daaka, Y

Science 1999
16580177 Opposing effects of beta-arrestin1 and beta-arrestin2 on activation and degradation of Src induced by protease-activated receptor 1

Kuo, FT, Fu, HW, Lu, TL

Cell Signal 2006
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Orthologous Events
F2R:ARRB1 binds MAPKs, SRC-1 (Bos taurus)
F2R:ARRB1 binds MAPKs, SRC-1 (Caenorhabditis elegans)
F2R:ARRB1 binds MAPKs, SRC-1 (Canis familiaris)
F2R:ARRB1 binds MAPKs, SRC-1 (Danio rerio)
F2R:ARRB1 binds MAPKs, SRC-1 (Mus musculus)
F2R:ARRB1 binds MAPKs, SRC-1 (Rattus norvegicus)
F2R:ARRB1 binds MAPKs, SRC-1 (Sus scrofa)
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-04-16)
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