G beta:gamma signalling through PLC beta

Stable Identifier
R-HSA-418217
Type
Pathway
Species
Homo sapiens
Compartment
cytoplasmic side of plasma membrane
ReviewStatus
5/5
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G beta:gamma signalling through PLC beta
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Phospholipase C beta (PLCbeta) isoforms are activated by G-protein beta:gamma in the order PLCB3 > PLCB2 > PLCB1. Gbeta:gamma binds to the pleckstrin homology domain of PLC beta, increasing phospholipase activity and leading to increased hydrolysis of PIP2 to DAG and IP3.
Literature References
PubMed ID Title Journal Year
8383116 Activation of phospholipase C isozymes by G protein beta gamma subunits

Lee, CW, Park, D, Rhee, SG, Jhon, DY, Lee, KH

J Biol Chem 1993
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Cross References
BioModels Database
Authored
Jupe, S  (2009-04-17)
Reviewed
Akkerman, JW  (2009-06-03)
Created
Jupe, S  (2009-04-17)
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