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RUVBL2 [nucleoplasm]
Stable Identifier
R-HSA-418321
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Reptin, RuvB-like 2, RUVB2_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O60832 DKC1
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere Extension By Telomerase (Homo sapiens)
Biogenesis and assembly of the telomerase RNP (Homo sapiens)
RUVBL2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y230 RUVBL2
Gene Names
RUVBL2, INO80J, TIP48, TIP49B, CGI-46
Chain
initiator methionine:, chain:2-463
Reference Genes
BioGPS Gene:10856 RUVBL2
COSMIC (genes):RUVBL2 RUVBL2
CTD Gene:10856 RUVBL2
dbSNP Gene:10856 RUVBL2
ENSEMBL:ENSG00000183207 RUVBL2
ENSEMBL_homo_sapiens_GENE:ENSG00000183207.15 RUVBL2
HGNC:10475 RUVBL2
KEGG Gene (Homo sapiens):10856 RUVBL2
Monarch:10856 RUVBL2
NCBI Gene:10856 RUVBL2
OMIM:604788 RUVBL2
UCSC:Q9Y230 RUVBL2
Reference Transcript
RefSeq:XM_011526330.1 RUVBL2
RefSeq:NM_001321191.1 RUVBL2
RefSeq:NM_006666.2 RUVBL2
Other Identifiers
10856
11730398_a_at
11746743_a_at
11756378_x_at
1559946_PM_s_at
1559946_s_at
16863946
201459_PM_at
201459_at
35758_at
3838126
3838127
3838130
3838133
3838134
3838135
3838136
3838138
3838139
3838142
3838143
3838144
3838145
3838147
3838148
3838149
8030113
GO:0000166
GO:0000228
GO:0000492
GO:0000723
GO:0000786
GO:0000791
GO:0000812
GO:0000978
GO:0000979
GO:0001094
GO:0003677
GO:0003678
GO:0003714
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006260
GO:0006275
GO:0006281
GO:0006282
GO:0006310
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0006457
GO:0006974
GO:0008013
GO:0008094
GO:0012501
GO:0016020
GO:0016363
GO:0016787
GO:0016887
GO:0017025
GO:0023052
GO:0031011
GO:0031490
GO:0032200
GO:0032508
GO:0033044
GO:0034644
GO:0035267
GO:0042802
GO:0042803
GO:0042981
GO:0043226
GO:0043531
GO:0045739
GO:0045892
GO:0045893
GO:0045944
GO:0045995
GO:0048856
GO:0050821
GO:0051082
GO:0051117
GO:0051276
GO:0051726
GO:0060090
GO:0060382
GO:0065003
GO:0070062
GO:0071169
GO:0071339
GO:0071392
GO:0090090
GO:0097255
GO:0101031
GO:0120293
GO:0140097
GO:0140110
GO:0140585
GO:0140657
GO:1904507
GO:1904874
GO:1905168
GO:1990062
GO:1990904
GO:2000779
HMNXSV003031054
PH_hs_0028731
TC19000720.hg
g5730022_3p_at
g5730022_3p_s_at
Participates
as a component of
NuA4 [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
Biogenesis and assembly of the telomerase RNP
(Homo sapiens)
Cross References
RefSeq
XP_011524632.1
,
NP_001308120.1
,
NP_006657.1
OpenTargets
ENSG00000183207
IntEnz
3.6.4.12
GeneCards
Q9Y230
HPA
ENSG00000183207-RUVBL2
Ensembl
ENSP00000473172
,
ENST00000595090
,
ENSG00000183207
PRO
Q9Y230
Pharos - Targets
Q9Y230
HMDB Protein
HMDBP07373
PDB
5OAF
,
6H7X
,
6HTS
,
7AHO
,
2XSZ
,
7P6X
,
2CQA
,
6FO1
,
8X19
,
6QI9
,
6IGM
,
6K0R
,
8X15
,
6QI8
,
7ZI4
,
3UK6
,
8X1C
,
7OLE
Interactors (77)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y265 RUVBL1
1
RUVBL1 [nucleoplasm]
(R-HSA-418323)
0.969
42
UniProt:Q9BVM2 DPCD
0.935
14
UniProt:P25490 YY1
1
YY1 [nucleoplasm]
(R-HSA-4086091)
0.888
11
UniProt:O96019 ACTL6A
1
ACTL6A [nucleoplasm]
(R-HSA-2980912)
0.857
11
UniProt:Q9NWS0 PIHD1
0.812
12
UniProt:O43257 ZNHI1
0.812
8
UniProt:Q9NV56 MRGBP
1
MRGBP [nucleoplasm]
(R-HSA-3322953)
0.812
7
UniProt:Q15906 CFL1
1
VPS72 [nucleoplasm]
(R-HSA-3321992)
0.812
7
UniProt:O60832 DKC1
1
DKC1 [nucleoplasm]
(R-HSA-163102)
0.812
9
UniProt:Q8NBZ0 INO80E
1
INO80E [nucleoplasm]
(R-HSA-5689552)
0.788
8
UniProt:Q9NXR8 ING3
1
ING3 [nucleoplasm]
(R-HSA-3215168)
0.788
6
UniProt:Q9H9F9 ACTR5
1
ACTR5 [nucleoplasm]
(R-HSA-5688913)
0.788
6
UniProt:O95619 YEATS4
1
YEATS4 [nucleoplasm]
(R-HSA-3322940)
0.788
6
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.78
4
UniProt:Q9H6R7 WDCP
2
WDCP(1-680)-p-7Y-ALK(1061-1620) fusion [cytosol]
(R-HSA-9700468)
WDCP(1-680)-ALK(1061-1620) fusion [cytosol]
(R-HSA-9700460)
0.744
5
UniProt:Q96L91 EP400
1
EP400 [nucleoplasm]
(R-HSA-3321987)
0.744
5
UniProt:Q52LR7 EPC2
0.725
5
UniProt:Q9NPF5 DMAP1
1
DMAP1 [nucleoplasm]
(R-HSA-212166)
0.725
5
UniProt:Q9GZN1 ARP6
0.725
5
UniProt:Q05BQ5 MBTD1
0.725
6
UniProt:Q9H981 ACTR8
1
ACTR8 [nucleoplasm]
(R-HSA-5689565)
0.725
5
UniProt:Q9H2F5 EPC1
1
EPC1 [nucleoplasm]
(R-HSA-3321978)
0.725
6
UniProt:Q9ULG1 INO80
1
INO80 [nucleoplasm]
(R-HSA-5688910)
0.725
6
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.725
5
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.718
6
UniProt:O43156 TTI1
0.69
5
UniProt:Q9UBU8 MORF4L1
1
MORF4L1 [nucleoplasm]
(R-HSA-3321982)
0.643
4
UniProt:Q9H6T3 RPAP3
0.643
3
UniProt:P0C0S5 H2AZ1
1
H2AFZ [extracellular region]
(R-HSA-977575)
0.643
6
UniProt:O94763 RMP
0.643
4
UniProt:Q9C086 INO80B
1
INO80B [nucleoplasm]
(R-HSA-5689599)
0.643
5
UniProt:Q6ZRS2 SRCAP
0.643
4
UniProt:Q6PI98 INO80C
1
INO80C [nucleoplasm]
(R-HSA-5689605)
0.643
4
UniProt:Q9H0E9 BRD8
1
BRD8 [nucleoplasm]
(R-HSA-3321977)
0.643
4
UniProt:Q9UHR6 ZNHI2
0.643
4
UniProt:Q53TQ3 INO80D
1
INO80D [nucleoplasm]
(R-HSA-5689559)
0.643
4
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.643
3
UniProt:Q9Y4A5 TRRAP
1
TRRAP [nucleoplasm]
(R-HSA-3322951)
0.643
5
UniProt:Q9Y2X3 NOP58
3
polySUMO2-K467,K497-NOP58 [nucleoplasm]
(R-HSA-4570460)
monoSUMO1-K467,K497-NOP58 [nucleoplasm]
(R-HSA-4570470)
NOP58 [nucleoplasm]
(R-HSA-4570488)
0.643
4
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.643
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
13
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.615
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
8
UniProt:P36873 PPP1CC
1
PPP1CC [cytosol]
(R-HSA-163443)
0.569
3
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.569
3
UniProt:O00469 PLOD2
1
PLOD2 [endoplasmic reticulum membrane]
(R-HSA-1981126)
0.564
2
UniProt:Q9UDY4 DNJB4
0.556
3
UniProt:Q8IW40 CC103
0.556
3
UniProt:Q8AZK7 EBNA5
0.527
2
UniProt:Q92993-2 KAT5
0.527
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:O94805 ACTL6B
1
ACTL6B [nucleoplasm]
(R-HSA-5225616)
0.527
2
UniProt:Q9NUG6 PDRG1
0.527
2
UniProt:O14802 POLR3A
2
POLR3A [cytosol]
(R-HSA-1964433)
POLR3A [nucleoplasm]
(R-HSA-83700)
0.527
3
UniProt:Q9HAF1 MEAF6
1
MEAF6 [nucleoplasm]
(R-HSA-3318448)
0.527
3
UniProt:Q6P4R8 NFRKB
1
NFRKB [nucleoplasm]
(R-HSA-5689578)
0.527
3
UniProt:Q8N5I9 NOPC1
0.527
2
UniProt:Q96MX6 DAA10
0.527
2
UniProt:P0C1Z6 TFPT
1
TFPT [nucleoplasm]
(R-HSA-5689542)
0.527
3
UniProt:Q96A08 H2BC1
9
HIST1H2BA [nucleoplasm]
(R-HSA-181916)
Ub-122-HIST1H2BA [nucleoplasm]
(R-HSA-3364020)
AcK22-HIST1H2BA [nucleoplasm]
(R-HSA-4568647)
AcK17-HIST1H2BA [nucleoplasm]
(R-HSA-4568631)
AcK14-HIST1H2BA [nucleoplasm]
(R-HSA-4568615)
AcK7-HIST1H2BA [nucleoplasm]
(R-HSA-4568624)
HIST1H2BA [extracellular region]
(R-HSA-977582)
AcK-HIST1H2BA [nucleoplasm]
(R-HSA-4549263)
Ub-HIST1H2BA [nucleoplasm]
(R-HSA-6782561)
0.527
3
UniProt:Q9UBB6 NCDN
0.527
2
UniProt:Q9UHV9 PFDN2
1
PFDN2 [cytosol]
(R-HSA-379544)
0.527
2
UniProt:O70591 PFD2
0.527
2
UniProt:Q8N5S9 CAMKK1
4
p-CAMKK1 [nucleoplasm]
(R-HSA-444232)
CAMKK1 [nucleoplasm]
(R-HSA-442775)
CAMKK1 [cytosol]
(R-HSA-9619232)
p-CAMKK1 [cytosol]
(R-HSA-9619356)
0.527
2
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
2
UniProt:Q96EZ8 MCRS1
1
MCRS1 [nucleoplasm]
(R-HSA-3321849)
0.527
3
UniProt:P19388 POLR2E
2
POLR2E [nucleoplasm]
(R-HSA-83713)
POLR2E [cytosol]
(R-HSA-1964438)
0.527
3
UniProt:Q6PI26 SHQ1
1
SHQ1 [nucleoplasm]
(R-HSA-9671152)
0.527
2
UniProt:Q8IXW5 RPAP2
1
RPAP2 [nucleoplasm]
(R-HSA-6810227)
0.527
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:P60122
1
RUVBL1 [nucleoplasm]
(R-MMU-418323)
0.527
2
UniProt:Q96SI1 KCTD15
1
KCTD15 [nucleoplasm]
(R-HSA-8864337)
0.527
2
UniProt:Q8BPA8 DPCD
0.499
2
UniProt:Q9BTT0 AN32E
0.499
5
UniProt:Q15029 EFTUD2
1
EFTUD2 [nucleoplasm]
(R-HSA-71883)
0.483
2
UniProt:Q12692
1
HTZ1 [nucleoplasm]
(R-SCE-8862427)
0.462
2
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