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RUVBL1 [nucleoplasm]
Stable Identifier
R-HSA-418323
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Pontin, RuvB-like 1, RUVB1_HUMAN, Tip49a
Locations in the PathwayBrowser for interactor UniProt:O60832 DKC1
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere Extension By Telomerase (Homo sapiens)
Biogenesis and assembly of the telomerase RNP (Homo sapiens)
RUVBL1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Beta-catenin recruits TRRAP/KAT5 HAT components (Homo sapiens)
RUVBL1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y265 RUVBL1
Gene Names
RUVBL1, INO80H, NMP238, TIP49, TIP49A
Chain
chain:1-456
Reference Genes
BioGPS Gene:8607 RUVBL1
COSMIC (genes):RUVBL1 RUVBL1
CTD Gene:8607 RUVBL1
dbSNP Gene:8607 RUVBL1
ENSEMBL:ENSG00000175792 RUVBL1
ENSEMBL_homo_sapiens_GENE:ENSG00000175792.12 RUVBL1
HGNC:10474 RUVBL1
KEGG Gene (Homo sapiens):8607 RUVBL1
Monarch:8607 RUVBL1
NCBI Gene:8607 RUVBL1
OMIM:603449 RUVBL1
UCSC:Q9Y265 RUVBL1
Reference Transcript
RefSeq:NM_003707.2 RUVBL1
RefSeq:NM_001319084.1 RUVBL1
Other Identifiers
11715833_a_at
11715834_x_at
11747775_x_at
16958812
201614_PM_s_at
201614_s_at
2694138
2694139
2694140
2694141
2694143
2694146
2694148
2694149
2694150
2694151
2694153
2694154
2694155
2694158
2694160
2694161
40124_at
8090448
8607
A_24_P148811
A_32_P30693
GE62349
GO:0000166
GO:0000228
GO:0000492
GO:0000723
GO:0000786
GO:0000812
GO:0001094
GO:0003678
GO:0003713
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006260
GO:0006275
GO:0006281
GO:0006282
GO:0006310
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0006974
GO:0007049
GO:0007283
GO:0008094
GO:0012501
GO:0016020
GO:0016363
GO:0016787
GO:0016887
GO:0017025
GO:0022414
GO:0023052
GO:0031011
GO:0032200
GO:0032508
GO:0033044
GO:0035267
GO:0042981
GO:0043226
GO:0043531
GO:0045296
GO:0045739
GO:0045893
GO:0045995
GO:0048856
GO:0050821
GO:0051117
GO:0051276
GO:0051301
GO:0051726
GO:0060382
GO:0065003
GO:0070062
GO:0071339
GO:0090263
GO:0097255
GO:0101031
GO:0120293
GO:0140097
GO:0140110
GO:0140657
GO:1904507
GO:1904874
GO:1905168
GO:1990062
GO:1990904
GO:2000779
HMNXSV003038690
ILMN_1656540
ILMN_1693108
ILMN_1791945
PH_hs_0014095
TC03001751.hg
g4506752_3p_s_at
Participates
as a component of
USP37:RUVLB1:PSMC5 [nucleoplasm] (Homo sapiens)
NuA4 [nucleoplasm] (Homo sapiens)
HJURP:NPM1:RBBP4:RBBP7:RUVBL1:CENPA:H4 [nucleoplasm] (Homo sapiens)
HJURP:NPM1:RBBP4:RBBP7:RUVBL1 [nucleoplasm] (Homo sapiens)
INO80 complex [nucleoplasm] (Homo sapiens)
LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm] (Rattus norvegicus)
TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm] (Homo sapiens)
as an input of
Beta-catenin recruits TRRAP/KAT5 HAT components (Homo sapiens)
This entity regulates
Positively
Biogenesis and assembly of the telomerase RNP
(Homo sapiens)
Inferred To
ruvbl1 [nucleoplasm]
(Xenopus tropicalis)
RUVBL1 [nucleoplasm]
(Bos taurus)
RUVBL1 [nucleoplasm]
(Caenorhabditis elegans)
RUVBL1 [nucleoplasm]
(Canis familiaris)
RUVBL1 [nucleoplasm]
(Danio rerio)
RUVBL1 [nucleoplasm]
(Drosophila melanogaster)
RUVBL1 [nucleoplasm]
(Gallus gallus)
RUVBL1 [nucleoplasm]
(Mus musculus)
RUVBL1 [nucleoplasm]
(Rattus norvegicus)
RUVBL1 [nucleoplasm]
(Schizosaccharomyces pombe)
RUVBL1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_003698.1
,
NP_001306013.1
OpenTargets
ENSG00000175792
ZINC - Substances
RUVB1_HUMAN
ZINC target
Q9Y265
PRO
Q9Y265
PDB
2C9O
,
6HTS
,
7OLE
,
5OAF
,
8X1C
,
2XSZ
,
6QI8
,
8X15
,
6IGM
,
7P6X
,
8X19
,
7ZI4
,
6K0R
,
6QI9
,
6FO1
,
7AHO
IntEnz
3.6.4.12
GeneCards
Q9Y265
HPA
ENSG00000175792-RUVBL1
Ensembl
ENST00000322623
,
ENSP00000318297
,
ENSG00000175792
Pharos - Targets
Q9Y265
ZINC - Predictions - Purchasable
RUVB1_HUMAN
HMDB Protein
HMDBP11929
Interactors (68)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.969
42
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.857
9
UniProt:Q9NWS0 PIHD1
0.855
14
UniProt:P25490 YY1
1
YY1 [nucleoplasm]
(R-HSA-4086091)
0.853
10
UniProt:O96019 ACTL6A
1
ACTL6A [nucleoplasm]
(R-HSA-2980912)
0.848
12
UniProt:Q15906 CFL1
1
VPS72 [nucleoplasm]
(R-HSA-3321992)
0.84
11
UniProt:Q8NBZ0 INO80E
1
INO80E [nucleoplasm]
(R-HSA-5689552)
0.837
10
UniProt:O60832 DKC1
1
DKC1 [nucleoplasm]
(R-HSA-163102)
0.824
10
UniProt:O43257 ZNHI1
0.812
9
UniProt:Q9NV56 MRGBP
1
MRGBP [nucleoplasm]
(R-HSA-3322953)
0.812
9
UniProt:Q9H9F9 ACTR5
1
ACTR5 [nucleoplasm]
(R-HSA-5688913)
0.788
7
UniProt:O95619 YEATS4
1
YEATS4 [nucleoplasm]
(R-HSA-3322940)
0.788
7
UniProt:Q9BVM2 DPCD
0.744
6
UniProt:Q9H6R7 WDCP
2
WDCP(1-680)-p-7Y-ALK(1061-1620) fusion [cytosol]
(R-HSA-9700468)
WDCP(1-680)-ALK(1061-1620) fusion [cytosol]
(R-HSA-9700460)
0.744
6
UniProt:Q9UHR6 ZNHI2
0.742
9
UniProt:Q9H6T3 RPAP3
0.725
6
UniProt:Q9NXR8 ING3
1
ING3 [nucleoplasm]
(R-HSA-3215168)
0.725
6
UniProt:O94763 RMP
0.725
6
UniProt:Q9GZN1 ARP6
0.725
6
UniProt:Q9ULG1 INO80
1
INO80 [nucleoplasm]
(R-HSA-5688910)
0.725
6
UniProt:Q9Y4A5 TRRAP
1
TRRAP [nucleoplasm]
(R-HSA-3322951)
0.725
7
UniProt:Q96L91 EP400
1
EP400 [nucleoplasm]
(R-HSA-3321987)
0.725
7
UniProt:O95905 ECD
0.677
8
UniProt:O14746 TERT
1
TERT [nucleoplasm]
(R-HSA-163076)
0.644
11
UniProt:Q52LR7 EPC2
0.643
5
UniProt:Q9NPF5 DMAP1
1
DMAP1 [nucleoplasm]
(R-HSA-212166)
0.643
5
UniProt:Q9NUG6 PDRG1
0.643
5
UniProt:Q05BQ5 MBTD1
0.643
6
UniProt:Q9C086 INO80B
1
INO80B [nucleoplasm]
(R-HSA-5689599)
0.643
6
UniProt:Q6ZRS2 SRCAP
0.643
5
UniProt:Q9H0E9 BRD8
1
BRD8 [nucleoplasm]
(R-HSA-3321977)
0.643
5
UniProt:Q53TQ3 INO80D
1
INO80D [nucleoplasm]
(R-HSA-5689559)
0.643
3
UniProt:Q9H981 ACTR8
1
ACTR8 [nucleoplasm]
(R-HSA-5689565)
0.643
5
UniProt:Q9H2F5 EPC1
1
EPC1 [nucleoplasm]
(R-HSA-3321978)
0.643
6
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.643
3
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.619
10
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
15
UniProt:O43156 TTI1
0.597
7
UniProt:Q14164 IKBKE
5
monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
(R-HSA-4755535)
IKBKE [cytosol]
(R-HSA-450225)
p-S172-IKBKE [cytosol]
(R-HSA-450278)
K63polyUb-K30,K401-IKBKE [cytosol]
(R-HSA-9730436)
p-S172-IKBKE [nucleoplasm]
(R-HSA-4755521)
0.589
2
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
10
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.569
3
UniProt:Q92993-2 KAT5
0.527
2
UniProt:P0C0S5 H2AZ1
1
H2AFZ [extracellular region]
(R-HSA-977575)
0.527
4
UniProt:Q9Y4R8 TELO2
0.527
2
UniProt:Q15649 ZNHI3
0.527
4
UniProt:O94805 ACTL6B
1
ACTL6B [nucleoplasm]
(R-HSA-5225616)
0.527
3
UniProt:O14802 POLR3A
2
POLR3A [cytosol]
(R-HSA-1964433)
POLR3A [nucleoplasm]
(R-HSA-83700)
0.527
3
UniProt:Q9NWK9 BCD1
0.527
4
UniProt:Q6P4R8 NFRKB
1
NFRKB [nucleoplasm]
(R-HSA-5689578)
0.527
4
UniProt:Q8N5I9 NOPC1
0.527
4
UniProt:Q6PI98 INO80C
1
INO80C [nucleoplasm]
(R-HSA-5689605)
0.527
4
UniProt:P0C1Z6 TFPT
1
TFPT [nucleoplasm]
(R-HSA-5689542)
0.527
4
UniProt:Q96A08 H2BC1
9
HIST1H2BA [nucleoplasm]
(R-HSA-181916)
Ub-122-HIST1H2BA [nucleoplasm]
(R-HSA-3364020)
AcK22-HIST1H2BA [nucleoplasm]
(R-HSA-4568647)
AcK17-HIST1H2BA [nucleoplasm]
(R-HSA-4568631)
AcK14-HIST1H2BA [nucleoplasm]
(R-HSA-4568615)
AcK7-HIST1H2BA [nucleoplasm]
(R-HSA-4568624)
HIST1H2BA [extracellular region]
(R-HSA-977582)
AcK-HIST1H2BA [nucleoplasm]
(R-HSA-4549263)
Ub-HIST1H2BA [nucleoplasm]
(R-HSA-6782561)
0.527
4
UniProt:Q9UHK0 NUFP1
0.527
3
UniProt:Q8N5S9 CAMKK1
4
p-CAMKK1 [nucleoplasm]
(R-HSA-444232)
CAMKK1 [nucleoplasm]
(R-HSA-442775)
CAMKK1 [cytosol]
(R-HSA-9619232)
p-CAMKK1 [cytosol]
(R-HSA-9619356)
0.527
2
UniProt:Q96EZ8 MCRS1
1
MCRS1 [nucleoplasm]
(R-HSA-3321849)
0.527
4
UniProt:P19388 POLR2E
2
POLR2E [nucleoplasm]
(R-HSA-83713)
POLR2E [cytosol]
(R-HSA-1964438)
0.527
5
UniProt:Q6PI26 SHQ1
1
SHQ1 [nucleoplasm]
(R-HSA-9671152)
0.527
4
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:Q9Y2X3 NOP58
3
polySUMO2-K467,K497-NOP58 [nucleoplasm]
(R-HSA-4570460)
monoSUMO1-K467,K497-NOP58 [nucleoplasm]
(R-HSA-4570470)
NOP58 [nucleoplasm]
(R-HSA-4570488)
0.527
2
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.527
4
UniProt:G3I183 G3I183
0.524
2
UniProt:O75665 OFD1
1
OFD1 [cytosol]
(R-HSA-380318)
0.508
3
UniProt:P63279 UBE2I
9
monoSUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [nuclear envelope]
(R-HSA-4655408)
SUMO2-C93-UBE2I [cytosol]
(R-HSA-4656944)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
UBE2I [cytosol]
(R-HSA-4655342)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
UBE2I [nucleoplasm]
(R-HSA-912481)
0.499
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.499
3
UniProt:Q15029 EFTUD2
1
EFTUD2 [nucleoplasm]
(R-HSA-71883)
0.483
2
UniProt:P03366 POL
0.462
2
UniProt:Q12692
1
HTZ1 [nucleoplasm]
(R-SCE-8862427)
0.462
2
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