Reactome | WRAP53 [nucleoplasm]

WRAP53 [nucleoplasm]

Stable Identifier

R-HSA-418386

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

TCAB1, telomerase Cajal body protein 1, WD repeat containing, antisense to TP53, WDR79, WD repeat-containing protein 79, WDR79_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O60832 DKC1

Expand all

External Reference Information

External Reference

UniProt:Q9BUR4 WRAP53

Gene Names

WRAP53, TCAB1, WDR79

Chain

chain:1-548

Reference Genes

BioGPS Gene:55135 WRAP53

COSMIC (genes):WRAP53 WRAP53

CTD Gene:55135 WRAP53

dbSNP Gene:55135 WRAP53

ENSEMBL:ENSG00000141499 WRAP53

ENSEMBL_homo_sapiens_GENE:ENSG00000141499.18 WRAP53

HGNC:25522 WRAP53

KEGG Gene (Homo sapiens):55135 WRAP53

Monarch:55135 WRAP53

NCBI Gene:55135 WRAP53

OMIM:612661 WRAP53

UCSC:Q9BUR4 WRAP53

Reference Transcript

Other Identifiers

11719306_a_at

16830631

220258_PM_s_at

220258_s_at

3708960

3708962

3708963

3708964

3708965

3708966

3708967

3708968

3708969

3708970

3708971

3708972

3708974

3708977

3708978

3708980

3708981

3708984

3708985

3708987

3708988

3708989

44563_PM_at

44563_at

55135

8004556

A_14_P100302

A_23_P55064

A_33_P3274034

GE55729

GO:0000781

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005697

GO:0005829

GO:0006281

GO:0006310

GO:0006974

GO:0007004

GO:0015030

GO:0016604

GO:0030576

GO:0031625

GO:0032200

GO:0032203

GO:0034337

GO:0035861

GO:0042393

GO:0042802

GO:0043226

GO:0044877

GO:0045739

GO:0051087

GO:0051973

GO:0070034

GO:0090666

GO:0090671

GO:1904851

GO:1904867

GO:1905168

GO:2000781

GO:2001034

HMNXSV003039201

HMNXSV003057197

ILMN_1693669

PH_hs_0025608

TC17000113.hg

TC17002041.hg

g8922395_3p_s_at

Participates

as an input of

Biogenesis and assembly of the telomerase RNP (Homo sapiens)

as a component of

Telomerase RNP [nucleoplasm] (Homo sapiens)

Other forms of this molecule

Unfolded WRAP53 [cytosol]

Inferred To

gnr1 [nucleoplasm] (Schizosaccharomyces pombe)

SWT21 [nucleoplasm] (Saccharomyces cerevisiae)

tcab-1 [nucleoplasm] (Caenorhabditis elegans)

WRAP53 [nucleoplasm] (Bos taurus)

WRAP53 [nucleoplasm] (Canis familiaris)

WRAP53 [nucleoplasm] (Dictyostelium discoideum)

WRAP53 [nucleoplasm] (Gallus gallus)

WRAP53 [nucleoplasm] (Plasmodium falciparum)

WRAP53 [nucleoplasm] (Sus scrofa)

WDR79 [nucleoplasm] (Drosophila melanogaster)

Wrap53 [nucleoplasm] (Mus musculus)

Wrap53 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001137462.1, NP_001137464.1, NP_060551.2, NP_001137463.1

OpenTargets

ENSG00000141499

HPA

ENSG00000141499-WRAP53

GeneCards

Q9BUR4

Ensembl

ENSP00000379727, ENSP00000411061, ENST00000431639, ENSP00000397219, ENST00000457584, ENST00000316024, ENST00000396463, ENSP00000324203, ENSG00000141499

PRO

Q9BUR4

Pharos - Targets

Q9BUR4

Orphanet

20148

PDB

7BGB, 7V9A, 7TRC, 8OUE, 8OUF

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60832 DKC1	1	DKC1 [nucleoplasm] (R-HSA-163102)	0.835	9
UniProt:P78371 CCT2	3	CCT2 [extracellular region] (R-HSA-6806220) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [cytosol] (R-HSA-390464)	0.69	6
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.69	6
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.69	7
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.643	5
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.643	3
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.643	3
IntAct:EBI-1772365 TERC			0.623	3
UniProt:P38432 COIL			0.558	4
UniProt:Q16637 SMN1	2	SMN1 [nucleoplasm] (R-HSA-191892) SMN1 [cytosol] (R-HSA-191839)	0.558	5
UniProt:Q5T6F2 UBAP2			0.556	3
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.556	3
UniProt:P50990 CCT8	5	CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [cytosol] (R-HSA-390449)	0.527	2
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.527	2
UniProt:Q9NY12-2 GAR1			0.527	2
UniProt:Q8N2R8 FA43A			0.527	3
UniProt:Q9NY12 GAR1	1	GAR1 [nucleoplasm] (R-HSA-6790707)	0.527	3
UniProt:O77622 CCT6	1	TCP-1-zeta [cytosol] (R-OCU-391446)	0.499	2

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