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WRAP53 [nucleoplasm]
Stable Identifier
R-HSA-418386
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
TCAB1, telomerase Cajal body protein 1, WD repeat containing, antisense to TP53, WDR79, WD repeat-containing protein 79, WDR79_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9NY12 GAR1
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere Extension By Telomerase (Homo sapiens)
Biogenesis and assembly of the telomerase RNP (Homo sapiens)
WRAP53 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BUR4 WRAP53
Gene Names
WRAP53, TCAB1, WDR79
Chain
chain:1-548
Reference Genes
BioGPS Gene:55135 WRAP53
COSMIC (genes):WRAP53 WRAP53
CTD Gene:55135 WRAP53
dbSNP Gene:55135 WRAP53
ENSEMBL:ENSG00000141499 WRAP53
HGNC:25522 WRAP53
KEGG:hsa:55135 WRAP53
Monarch:55135 WRAP53
NCBI Gene:55135 WRAP53
OMIM:612661 WRAP53
UCSC:Q9BUR4 WRAP53
Reference Transcript
RefSeq:NM_001143990.1 WRAP53
RefSeq:NM_001143992.1 WRAP53
RefSeq:NM_018081.2 WRAP53
RefSeq:NM_001143991.1 WRAP53
Other Identifiers
11719306_a_at
11761638_at
16830631
220258_PM_s_at
220258_s_at
3708960
3708962
3708963
3708964
3708965
3708966
3708967
3708968
3708969
3708970
3708971
3708972
3708974
3708975
3708976
3708977
3708978
3708979
3708980
3708981
3708982
3708983
3708984
3708985
3708987
3708988
3708989
3708990
44563_PM_at
44563_at
55135
8004556
A_14_P100302
A_23_P55064
A_33_P3274034
GE55729
GO:0000781
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005697
GO:0005829
GO:0006281
GO:0007004
GO:0015030
GO:0016604
GO:0030576
GO:0031625
GO:0032200
GO:0032203
GO:0032212
GO:0034337
GO:0035861
GO:0042393
GO:0042802
GO:0043226
GO:0044877
GO:0045739
GO:0051087
GO:0070034
GO:0090666
GO:0090671
GO:0140104
GO:0140597
GO:0140691
GO:1904851
GO:1904867
GO:1905168
GO:2000781
GO:2001034
HMNXSV003039201
HMNXSV003057197
ILMN_1693669
PH_hs_0025608
TC17000113.hg
TC17002041.hg
g8922395_3p_s_at
Participates
as an input of
Biogenesis and assembly of the telomerase RNP (Homo sapiens)
as a component of
Telomerase RNP [nucleoplasm] (Homo sapiens)
Other forms of this molecule
Unfolded WRAP53 [cytosol]
Inferred To
gnr1 [nucleoplasm]
(Schizosaccharomyces pombe)
SWT21 [nucleoplasm]
(Saccharomyces cerevisiae)
tcab-1 [nucleoplasm]
(Caenorhabditis elegans)
WRAP53 [nucleoplasm]
(Bos taurus)
WRAP53 [nucleoplasm]
(Canis familiaris)
WRAP53 [nucleoplasm]
(Dictyostelium discoideum)
WRAP53 [nucleoplasm]
(Gallus gallus)
WRAP53 [nucleoplasm]
(Plasmodium falciparum)
WRAP53 [nucleoplasm]
(Sus scrofa)
WDR79 [nucleoplasm]
(Drosophila melanogaster)
Wrap53 [nucleoplasm]
(Mus musculus)
Wrap53 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_001137463.1
,
NP_001137462.1
,
NP_001137464.1
,
NP_060551.2
OpenTargets
ENSG00000141499
ENSEMBL
ENST00000457584
,
ENST00000396463
,
ENST00000316024
,
ENSP00000411061
,
ENSP00000397219
,
ENSP00000379727
,
ENSP00000324203
,
ENST00000431639
HPA
ENSG00000141499-WRAP53
PRO
Q9BUR4
Pharos - Targets
Q9BUR4
Orphanet
WRAP53
GlyGen
Q9BUR4
PDB
7BGB
,
7TRC
,
8OUF
,
7V9A
,
8OUE
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60832 DKC1
1
DKC1 [nucleoplasm]
(R-HSA-163102)
0.835
9
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.69
7
UniProt:P78371 CCT2
3
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
CCT2 [extracellular region]
(R-HSA-6806220)
CCT2 [cytosol]
(R-HSA-390464)
0.69
6
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.69
6
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.643
3
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.643
3
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.643
5
IntAct:EBI-1772365 TERC
0.623
3
UniProt:Q16637 SMN1
2
SMN1 [nucleoplasm]
(R-HSA-191892)
SMN1 [cytosol]
(R-HSA-191839)
0.558
5
UniProt:P38432 COIL
0.558
4
UniProt:Q08AM6 VAC14
3
VAC14 [Golgi membrane]
(R-HSA-1806235)
VAC14 [early endosome membrane]
(R-HSA-1806207)
VAC14 [late endosome membrane]
(R-HSA-1806219)
0.556
3
UniProt:Q5T6F2 UBAP2
0.556
3
UniProt:Q9NY12 GAR1
1
GAR1 [nucleoplasm]
(R-HSA-6790707)
0.527
3
UniProt:Q8N2R8 FA43A
0.527
3
UniProt:Q9NY12-2 GAR1
0.527
2
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.527
2
UniProt:P50990 CCT8
5
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [cytosol]
(R-HSA-390449)
0.527
2
UniProt:O77622 CCT6
1
TCP-1-zeta [cytosol]
(R-OCU-391446)
0.499
2
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