PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release

Stable Identifier
R-HSA-418442
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, platelet dense tubular network membrane
ReviewStatus
5/5
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PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release
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IRAG, PKG1(cGKI), and IP3 receptor type 1 can be isolated as a complex in human platelets. Phosphorylation of IRAG by PKG1 inhibits IP3 receptor-mediated Ca2+ release, representing the primary mechanism by which NO suppresses platelet activation.

Literature References
PubMed ID Title Journal Year
16990611 IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation

Kocher, T, Massberg, S, Hofmann, F, Konrad, I, Werner, M, Eiglsperger, C, Schlossmann, J, Antl, M, von Brühl, ML, Wilm, M

Blood 2007
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Output
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as an event of
Catalyst Activity

cGMP-dependent protein kinase activity of Cyclic GMP-dependent protein kinases (PKGs) [cytosol]

Physical Entity
Cyclic GMP-dependent protein kinases (PKGs) [cytosol] (Homo sapiens)
Activity
cGMP-dependent protein kinase activity (GO:0004692)
Orthologous Events
PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Bos taurus)
PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Canis familiaris)
PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Danio rerio)
PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Gallus gallus)
PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Mus musculus)
PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Rattus norvegicus)
PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Sus scrofa)
PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Xenopus tropicalis)
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-04-22)
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