Reactome | PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release

PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release

Stable Identifier

R-HSA-418442

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, platelet dense tubular network membrane

ReviewStatus

5/5

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PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release

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IRAG, PKG1(cGKI), and IP3 receptor type 1 can be isolated as a complex in human platelets. Phosphorylation of IRAG by PKG1 inhibits IP3 receptor-mediated Ca2+ release, representing the primary mechanism by which NO suppresses platelet activation.

Literature References

PubMed ID	Title	Journal	Year
16990611	IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation Kocher, T, Massberg, S, Hofmann, F, Konrad, I, Werner, M, Eiglsperger, C, Schlossmann, J, Antl, M, von Brühl, ML, Wilm, M	Blood	2007