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PDE3A [cytosol]
Stable Identifier
R-HSA-418505
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phosphodiesterase 3A, cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A, PDE3A_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
PDE3A hydrolyses cAMP to AMP (Homo sapiens)
PDE3A [cytosol] (Homo sapiens)
PDE3A inhibitors bind PDE3A (Homo sapiens)
PDE3A [cytosol] (Homo sapiens)
PDE3A inhibitors:PDE3A [cytosol] (Homo sapiens)
PDE3A [cytosol] (Homo sapiens)
General
Can hydrolyze both cAMP and cGMP
External Reference Information
External Reference
UniProt:Q14432 PDE3A
Gene Names
PDE3A
Chain
chain:1-1141
Reference Genes
BioGPS Gene:5139 PDE3A
COSMIC (genes):PDE3A PDE3A
CTD Gene:5139 PDE3A
dbSNP Gene:5139 PDE3A
ENSEMBL:ENSG00000172572 PDE3A
ENSEMBL_homo_sapiens_GENE:ENSG00000172572.7 PDE3A
HGNC:8778 PDE3A
KEGG Gene (Homo sapiens):5139 PDE3A
Monarch:5139 PDE3A
NCBI Gene:5139 PDE3A
OMIM:123805 PDE3A
UCSC:Q14432 PDE3A
Reference Transcript
RefSeq:NM_000921.4 PDE3A
Other Identifiers
11737002_a_at
11737003_a_at
11737004_at
16748989
206389_PM_s_at
206389_s_at
228507_PM_at
228507_at
236300_PM_at
236300_at
3407454
3407455
3407456
3407470
3407483
3407485
3407486
3407487
3407488
3407489
3407490
3407492
3407494
3407495
3407496
3407497
3407498
3407499
3407500
3407501
3407506
3407507
3407508
3407509
3407510
3407511
3407569
3407571
3407573
3407575
3407576
3407578
3407580
3407582
3407584
3407585
3407586
34650_at
5139
61343_at
68400_at
7954293
A_14_P117448
A_23_P60837
A_32_P4778
GE80966
GE892430
GO:0001556
GO:0003013
GO:0003824
GO:0004114
GO:0004115
GO:0004119
GO:0005515
GO:0005737
GO:0005829
GO:0006629
GO:0007165
GO:0007186
GO:0008081
GO:0009410
GO:0012501
GO:0016020
GO:0016787
GO:0019933
GO:0019934
GO:0022414
GO:0023052
GO:0030154
GO:0030284
GO:0040020
GO:0043066
GO:0043116
GO:0043117
GO:0043401
GO:0043951
GO:0046872
GO:0047555
GO:0048599
GO:0048856
GO:0060089
GO:0060282
GO:0060700
GO:0071321
GO:0071560
GO:0097190
GO:0099130
GO:0140013
HMNXSV003002428
HMNXSV003018599
Hs.191045.0.A1_3p_at
ILMN_1805415
PH_hs_0024403
TC12000227.hg
TC12002281.hg
U36798_at
g1039473_3p_at
g4505658_3p_a_at
Participates
as a component of
PDE3A inhibitors:PDE3A [cytosol] (Homo sapiens)
as an input of
PDE3A inhibitors bind PDE3A (Homo sapiens)
Inferred To
PDE3A [cytosol]
(Bos taurus)
PDE3A [cytosol]
(Caenorhabditis elegans)
PDE3A [cytosol]
(Canis familiaris)
PDE3A [cytosol]
(Dictyostelium discoideum)
PDE3A [cytosol]
(Gallus gallus)
PDE3A [cytosol]
(Mus musculus)
PDE3A [cytosol]
(Plasmodium falciparum)
PDE3A [cytosol]
(Rattus norvegicus)
PDE3A [cytosol]
(Sus scrofa)
Homologues of PDE3A [cytosol]
(Dictyostelium discoideum)
Homologues of PDE3A [cytosol]
(Plasmodium falciparum)
Cross References
RefSeq
NP_000912.3
ZINC - World Drugs
PDE3A_HUMAN
Guide to Pharmacology - Targets
1298
OpenTargets
ENSG00000172572
ZINC - FDA approved
PDE3A_HUMAN
ZINC - Substances
PDE3A_HUMAN
ZINC - Biogenic
PDE3A_HUMAN
ZINC target
Q14432
PRO
Q14432
PDB
7KWE
,
7L28
,
7LRD
,
7L29
,
7EG1
,
7L27
,
7LRC
,
7EG4
,
7EG0
IntEnz
3.1.4.17
HPA
ENSG00000172572-PDE3A
GeneCards
Q14432
Ensembl
ENSG00000172572
,
ENSP00000351957
,
ENST00000359062
Pharos - Targets
Q14432
ZINC - Predictions - Purchasable
PDE3A_HUMAN
Orphanet
23263
HMDB Protein
HMDBP00600
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y6D6 BIG1
0.576
6
UniProt:Q9Y6D5 ARFGEF2
1
ARFGEF2 [cytosol]
(R-HSA-391301)
0.499
5
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