Reactome | G alpha (s) signalling events

G alpha (s) signalling events

Stable Identifier

R-HSA-418555

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase (Tesmer et al. 1997), which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated. Another downstream effector of G alpha (s) is the protein tyrosine kinase c-Src (Ma et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
12036966	Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus Feldman, DS, Zamah, AM, Pierce, KL, Miller, WE, Kelly, F, Rapacciuolo, A, Rockman, HA, Koch, WJ, Luttrell, LM	J Biol Chem	2002