Activation of caspase-3

Stable Identifier
R-HSA-418845
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Activation of caspase-3
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The DCC-caspase activating complex activates caspase-3 through caspase-9.
Literature References
PubMed ID Title Journal Year
12011067 Mediation of the DCC apoptotic signal by DIP13 alpha

Wu, R, Yao, F, Liu, J, Finley RL, Jr, Morgan, M, Chen, YQ, Thorburn, A

J Biol Chem 2002
15573119 Netrin-1 and its receptors in tumorigenesis

Arakawa, H

Nat Rev Cancer 2004
Participants
Input
Output
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as an event of
Catalyst Activity

cysteine-type endopeptidase activity of DCC:DIP13alpha:Caspase-9 [plasma membrane]

Physical Entity
DCC:DIP13alpha:Caspase-9 [plasma membrane] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Activation of caspase-3 (Bos taurus)
Activation of caspase-3 (Canis familiaris)
Activation of caspase-3 (Mus musculus)
Activation of caspase-3 (Rattus norvegicus)
Activation of caspase-3 (Sus scrofa)
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-04-27)
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