Activation of Rac1

Stable Identifier
R-HSA-418856
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activation of Rac1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Rho GEF's DOCK180 and Trio directly associate with DCC, activate Rac-1 on DCC stimulation and cause cell spreading.
Literature References
PubMed ID Title Journal Year
18212043 Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance

Briançon-Marjollet, A, Ghogha, A, Nawabi, H, Triki, I, Auziol, C, Fromont, S, Piché, C, Enslen, H, Chebli, K, Cloutier, JF, Castellani, V, Debant, A, Lamarche-Vane, N

Mol Cell Biol 2008
18066058 Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling

Li, X, Gao, X, Liu, G, Xiong, W, Wu, J, Rao, Y

Nat Neurosci 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]

Physical Entity
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
Activation of Rac1 (Caenorhabditis elegans)
Activation of Rac1 (Canis familiaris)
Activation of Rac1 (Mus musculus)
Activation of Rac1 (Rattus norvegicus)
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-04-27)
Cite Us!