RhoGTPase GEF's recruited to DCC

Stable Identifier
R-HSA-418858
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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When Netrin-1 binds to the DCC-NCK1 complex, a conformational change in NCK1 promotes interaction between the SH2 domain proteins, leading to recruitment and activation of RhoGEFs DOCK180 and Trio. These GEFs mediate Netrin-1 signaling in axon outgrowth and guidance through their ability to activate Rac1 and Cdc42.
Literature References
PubMed ID Title Journal Year
15788770 Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion

Bouchard, JF, Tritsch, NX, Shekarabi, M, Moore, SW, Kennedy, TE, Morris, SJ

J Neurosci 2005
11817894 The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1

Shekarabi, M, Kennedy, TE

Mol Cell Neurosci 2002
18212043 Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance

Ghogha, A, Fromont, S, Piché, C, Debant, A, Briançon-Marjollet, A, Castellani, V, Enslen, H, Cloutier, JF, Chebli, K, Triki, I, Lamarche-Vane, N, Nawabi, H, Auziol, C

Mol Cell Biol 2008
12149262 The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism

Larose, L, Li, X, Meriane, M, Triki, I, Lamarche-Vane, N, Shekarabi, M, Kennedy, TE

J Biol Chem 2002
18066058 Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling

Li, X, Rao, Y, Gao, X, Liu, G, Wu, J, Xiong, W

Nat Neurosci 2008
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