Reactome | ADORA2A,B bind Ade-Rib

ADORA2A,B bind Ade-Rib

Stable Identifier

R-HSA-418925

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

A2a and A2b receptors bind adenosine

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Nucleotide-like (purinergic) receptors (Homo sapiens)
        
        Adenosine P1 receptors (Homo sapiens)
        
        ADORA2A,B bind Ade-Rib (Homo sapiens)

General

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Adenosine receptors A2a and A2b (ADORA2A and ADORA2B) bind extracellular adenosine (Ado-Rib) and are believed to play a role in regulating myocardial oxygen consumption and coronary blood flow (Peterfreund 1996). The A2A receptor is responsible for regulating myocardial blood flow by vasodilation of the coronary arteries, which increases blood flow to the myocardium, but may lead to hypotension. Just as in A1 receptors, this normally serves as a protective mechanism. A2B receptor work (Pierce KD et al, 1992) has lagged behind research in the other adenosine receptors.
Both ADORA receptors mediate their actions by coupling with the G protein alpha s subunit which activates adenylyl cyclase and increases intracellular cAMP concentrations. In surfactant physiology, the receptor:adenosine complex positively regulates surfactant export from lamellar bodies. (Cooper JA et al, 1995; Linden J et al, 1999). Adenosine deaminase (CECR1, ADA2) degrades extracellular adenosine (Ade-Rib), reducing or neutralising the positive regulatory effect of adenosine in surfactant export.

Literature References

PubMed ID	Title	Journal	Year
10496952	Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells Robeva, AS, Figler, H, Linden, J, Thai, T, Jin, X	Mol Pharmacol	1999
8527267	Adenosine receptor-induced cyclic AMP generation and inhibition of 5-hydroxytryptamine release in human platelets Alexander, SP, Hill, SJ, Horn, EH, Rubin, PC, Cooper, JA	Br J Clin Pharmacol	1995
1325798	Molecular cloning and expression of an adenosine A2b receptor from human brain Pierce, KD, Shine, J, Selbie, LA, Furlong, TJ	Biochem Biophys Res Commun	1992
8522976	Characterization and expression of the human A2a adenosine receptor gene Fink, JS, Gusella, J, MacCollin, M, Peterfreund, RA	J Neurochem	1996