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VE-cadherin [plasma membrane]
Stable Identifier
R-HSA-418992
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
CDH5, Cadherin-5
Icon
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Homo sapiens)
Cadherin trans-homodimer [cell junction] (Homo sapiens)
Classic Cadherin [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
Classic Cadherin [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Homo sapiens)
Cadherin:Catenin complex [plasma membrane] (Homo sapiens)
Classic Cadherin [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
Classic Cadherin [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
PI3K binds p-Y801,Y1054,Y1175-KDR in p-Y713-PECAM1:CDH5:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 (Homo sapiens)
p-Y713-PECAM1:CDH5:PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
p-Y713-PECAM1:CDH5:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
Phospho-PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 phosphorylates phosphoinositol-4,5-bisphosphate to yield phosphoinositol-3,4,5-trisphosphate (Homo sapiens)
p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
Phosphorylation of KDR (VEGFR2) and FLT4 (VEGFR3) and PECAM1 in PECAM1:CDH5:KDR:FLT4:CTNNB1 (Homo sapiens)
PECAM1:CDH5:KDR:FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
p-Y713-PECAM1:CDH5:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
Phosphorylation of PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 (Homo sapiens)
p-Y713-PECAM1:CDH5:PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
PAK1-3 phosphorylates VE-cadherin (Homo sapiens)
VE-cadherin-Catenin complex [plasma membrane] (Homo sapiens)
VE-cadherin [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P33151 CDH5
Gene Names
CDH5
Chain
signal peptide:1-25, propeptide:26-47, chain:48-784
Reference Genes
BioGPS Gene:1003 CDH5
COSMIC (genes):CDH5 CDH5
CTD Gene:1003 CDH5
dbSNP Gene:1003 CDH5
ENSEMBL:ENSG00000179776 CDH5
HGNC:1764 CDH5
KEGG:hsa:1003 CDH5
Monarch:1003 CDH5
NCBI Gene:1003 CDH5
OMIM:601120 CDH5
UCSC:P33151 CDH5
Reference Transcript
RefSeq:NM_001795.4 CDH5
Other Identifiers
1003
11721651_at
11745128_a_at
16819794
204677_PM_at
204677_at
3664673
3664675
3664676
3664677
3664678
3664680
3664681
3664683
3664684
3664686
3664689
3664690
3664691
3664692
3664693
3664694
3664697
3664698
3664699
3664700
3664701
3664702
3664703
3664704
3664705
37196_at
7996264
A_14_P122438
A_14_P129330
A_23_P129496
A_33_P3728167
GE60059
GO:0000902
GO:0001886
GO:0001932
GO:0001955
GO:0003013
GO:0005102
GO:0005509
GO:0005515
GO:0005654
GO:0005737
GO:0005886
GO:0005911
GO:0005912
GO:0005923
GO:0006874
GO:0007043
GO:0007155
GO:0007156
GO:0007179
GO:0008013
GO:0008285
GO:0009897
GO:0009986
GO:0010628
GO:0016020
GO:0016339
GO:0016342
GO:0016477
GO:0019903
GO:0030054
GO:0030335
GO:0030513
GO:0031115
GO:0031334
GO:0031965
GO:0034330
GO:0034332
GO:0035307
GO:0035633
GO:0043114
GO:0043184
GO:0043534
GO:0044325
GO:0044331
GO:0045296
GO:0045766
GO:0046872
GO:0048870
GO:0050728
GO:0070051
GO:0070161
GO:0070700
GO:0070830
GO:0071944
GO:0098609
GO:1902396
GO:1903142
GO:1990782
GO:2000114
GO:2000352
HMNXSV003051422
ILMN_1719236
PH_hs_0004397
TC16000514.hg
X79981_at
g4502726_3p_at
Participates
as a component of
PECAM1:CDH5:KDR:FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
p-Y713-PECAM1:CDH5:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
p-Y713-PECAM1:CDH5:PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
VE-cadherin-Catenin complex [plasma membrane] (Homo sapiens)
as a member of
Classic Cadherin [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-S665-VE-cadherin [plasma membrane]
Inferred To
Cdh5 [plasma membrane]
(Rattus norvegicus)
Ghost homologue of VE-cadherin [plasma membrane]
(Caenorhabditis elegans)
Ghost homologue of VE-cadherin [plasma membrane]
(Xenopus tropicalis)
VE-cadherin [plasma membrane]
(Danio rerio)
VE-cadherin [plasma membrane]
(Gallus gallus)
VE-cadherin [plasma membrane]
(Mus musculus)
CadN2 [plasma membrane]
(Drosophila melanogaster)
CDH5 [plasma membrane]
(Bos taurus)
CDH5 [plasma membrane]
(Canis familiaris)
CDH5 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001786.2
ENSEMBL
ENST00000341529
,
ENSP00000497290
,
ENST00000649567
,
ENSP00000344115
OpenTargets
ENSG00000179776
HPA
ENSG00000179776-CDH5
PRO
P33151
Pharos - Targets
P33151
GlyGen
P33151
HMDB Protein
HMDBP07521
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
0.893
8
UniProt:P35968 KDR
5
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
0.564
2
UniProt:P29353 SHC1
5
p-Y-SHC1 [cytosol]
(R-HSA-162568)
SHC1 [cytosol]
(R-HSA-74680)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
0.544
2
UniProt:P18850 ATF6
7
ATF6(1-380) [nucleoplasm]
(R-HSA-381211)
ATF6(420-670) [Golgi membrane]
(R-HSA-420814)
ATF6(380-419) [Golgi membrane]
(R-HSA-420817)
ATF6(1-380) [cytosol]
(R-HSA-381075)
ATF6(1-419) [Golgi membrane]
(R-HSA-420815)
ATF6 [Golgi membrane]
(R-HSA-381000)
ATF6 [endoplasmic reticulum membrane]
(R-HSA-381222)
0.527
2
UniProt:Q14145 KEAP1
3
KEAP1 [cytosol]
(R-HSA-976038)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.527
2
UniProt:Q14118 DAG1
15
DAG1 [endoplasmic reticulum membrane]
(R-HSA-9913254)
DAG1(654-895) [endoplasmic reticulum membrane]
(R-HSA-9913257)
DAG1(654-895) [Golgi membrane]
(R-HSA-9913184)
GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [Golgi lumen]
(R-HSA-8932424)
GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [extracellular region]
(R-HSA-9913190)
GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen]
(R-HSA-8931659)
GlcNAc,1,2-Man-DAG1 [Golgi lumen]
(R-HSA-5617087)
Man-DAG1 [Golgi lumen]
(R-HSA-8931888)
GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]
(R-HSA-8931656)
GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]
(R-HSA-8931673)
Man-DAG1 [endoplasmic reticulum lumen]
(R-HSA-5615647)
DAG1(30-653) [endoplasmic reticulum lumen]
(R-HSA-8931890)
DAG1(30-653) [cytosol]
(R-HSA-5615641)
DAG1(30-653) [extracellular region]
(R-HSA-2328152)
DAG1(654-895) [plasma membrane]
(R-HSA-2328154)
0.527
2
UniProt:Q709F0 ACAD11
1
ACAD11 [mitochondrial inner membrane]
(R-HSA-5695987)
0.527
2
UniProt:Q9ULK5 VANGL2
2
VANGL2 [plasma membrane]
(R-HSA-3965373)
pS5,S82,S84-VANGL2 [plasma membrane]
(R-HSA-4551547)
0.527
2
UniProt:Q9HCL2 GPAM
1
GPAM(1-828) [mitochondrial outer membrane]
(R-HSA-61855)
0.527
2
UniProt:O95470 SGPL1
1
PXLP-SGPL1 [endoplasmic reticulum membrane]
(R-HSA-428661)
0.527
2
UniProt:Q9P244 LRFN1
1
SALM2 [plasma membrane]
(R-HSA-204734)
0.527
2
UniProt:Q96HA1 POM121
1
POM121 [nuclear envelope]
(R-HSA-157747)
0.527
2
UniProt:P22059 OSBP
1
OSBP [cytosol]
(R-HSA-429725)
0.527
2
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