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NCAM1 interactions
Stable Identifier
R-HSA-419037
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
NCAM signaling for neurite out-growth (Homo sapiens)
NCAM1 interactions (Homo sapiens)
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The neural cell adhesion molecule, NCAM1 is generally considered as a cell adhesion mediator, but it is also considered to be a signal transducing receptor molecule. NCAM1 is involved in multiple cis- and trans-homophilic interactions. It is also involved in several heterophilic interactions with a broad range of other molecules, thereby modulating diverse biological phenomena including cellular adhesion, migration, proliferation, differentiation, survival and synaptic plasticity.
Literature References
PubMed ID
Title
Journal
Year
18607724
Extracellular Protein Interactions Mediated by the Neural Cell Adhesion Molecule, NCAM: Heterophilic Interactions Between NCAM and Cell Adhesion Molecules, Extracellular Matrix Proteins, and Viruses
Nielsen, J
,
Kulahin, N
,
Walmod, PS
Neurochem Res
2008
15662836
Zippers make signals: NCAM-mediated molecular interactions and signal transduction
Walmod, PS
,
Kolkova, K
,
Berezin, V
,
Bock, E
Neurochem Res
2004
Participants
Events
Interaction of NCAM1 with GFRalpha-1
(Homo sapiens)
Interaction of NCAM1:GFRalpha-1 with GDNF
(Homo sapiens)
Interaction of NCAM1 with Neurocan
(Homo sapiens)
Interaction of NCAM1 with collagens
(Homo sapiens)
Interaction of NCAM1 with Major prion protein (PrP)
(Homo sapiens)
Interaction of NCAM1 with agrin
(Homo sapiens)
Interaction of NCAM1 with contactin-2
(Homo sapiens)
NCAM1 binds to ATP
(Homo sapiens)
Polysialylation of NCAM1
(Homo sapiens)
NCAM1 interacts with T- and L-type VDCC
(Homo sapiens)
Participates
as an event of
NCAM signaling for neurite out-growth (Homo sapiens)
Orthologous Events
NCAM1 interactions (Canis familiaris)
NCAM1 interactions (Mus musculus)
NCAM1 interactions (Rattus norvegicus)
Authored
Garapati, P V (2009-02-24)
Reviewed
Walmod, PS (2009-05-26)
Maness, PF (2009-05-26)
Created
Garapati, P V (2009-04-28)
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