Reactome | ROCK2 [cytosol]

ROCK2 [cytosol]

Stable Identifier

R-HSA-419058

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Rho-associated protein kinase 2, ROCK2_HUMAN

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        ROCK1,2 bind ROCKi (Homo sapiens)
        
        ROCK1,ROCK2 [cytosol] (Homo sapiens)
        
        ROCK2 [cytosol] (Homo sapiens)
        
        ROCK1,ROCK2:ROCKi [cytosol] (Homo sapiens)
        
        ROCK1,ROCK2 [cytosol] (Homo sapiens)
        
        ROCK2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75116 ROCK2

Gene Names

ROCK2, KIAA0619

Chain

chain:1-1388

Reference Genes

BioGPS Gene:9475 ROCK2

COSMIC (genes):ROCK2 ROCK2

CTD Gene:9475 ROCK2

dbSNP Gene:9475 ROCK2

ENSEMBL:ENSG00000134318 ROCK2

ENSEMBL_homo_sapiens_GENE:ENSG00000134318.16 ROCK2

HGNC:10252 ROCK2

KEGG Gene (Homo sapiens):9475 ROCK2

Monarch:9475 ROCK2

NCBI Gene:9475 ROCK2

OMIM:604002 ROCK2

UCSC:O75116 ROCK2

Reference Transcript

Other Identifiers

11739384_a_at

11739385_x_at

11759302_at

16894491

202762_PM_at

202762_at

211504_PM_x_at

211504_x_at

2540460

2540461

2540462

2540478

2540479

2540480

2540481

2540482

2540483

2540484

2540485

2540488

2540489

2540491

2540492

2540493

2540494

2540495

2540496

2540497

2540498

2540499

2540500

2540501

2540502

2540503

2540504

2540506

2540509

2540511

2540513

2540514

2540515

2540516

2540519

2540527

2540528

2540529

2540537

2540538

2540539

35335_at

8050302

9475

A_23_P209689

A_24_P328333

A_33_P3257140

GE58346

GE86063

GO:0000166

GO:0000278

GO:0000281

GO:0000910

GO:0001837

GO:0001934

GO:0002931

GO:0003012

GO:0003013

GO:0003180

GO:0003723

GO:0003824

GO:0004672

GO:0004674

GO:0005198

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0006468

GO:0006939

GO:0006996

GO:0007010

GO:0007155

GO:0007163

GO:0007165

GO:0007249

GO:0007266

GO:0008092

GO:0010595

GO:0010613

GO:0010628

GO:0010629

GO:0010825

GO:0016020

GO:0016071

GO:0016301

GO:0016310

GO:0016525

GO:0016740

GO:0018105

GO:0018107

GO:0023052

GO:0030036

GO:0030154

GO:0030155

GO:0030335

GO:0030866

GO:0031032

GO:0031267

GO:0031644

GO:0032723

GO:0032956

GO:0034330

GO:0035509

GO:0036211

GO:0036464

GO:0042752

GO:0043226

GO:0043410

GO:0044788

GO:0045019

GO:0045616

GO:0046872

GO:0048156

GO:0048511

GO:0048598

GO:0048856

GO:0048870

GO:0050321

GO:0050877

GO:0051246

GO:0051298

GO:0051492

GO:0051496

GO:0051893

GO:0061157

GO:0070168

GO:0071394

GO:0071559

GO:0072518

GO:0072659

GO:0090271

GO:0097746

GO:0106310

GO:0110061

GO:0140096

GO:0150033

GO:1900037

GO:1901888

GO:1902004

GO:1902961

GO:1902966

GO:1902993

GO:1903140

GO:1903347

GO:1905145

GO:1905205

GO:1990776

GO:2000114

GO:2000145

HMNXSV003009755

HMNXSV003040969

Hs.58617.0.S2_3p_at

Hs.58617.0.S2_3p_x_at

ILMN_1659099

ILMN_2058337

PH_hs_0003771

TC02001576.hg

g4520224_3p_a_at

Participates

as a member of

as a candidate of

RHOH effectors [cytosol] (Homo sapiens)

Other forms of this molecule

Activated ROCK2 [cytosol]

Inferred To

ROCK2 [cytosol] (Bos taurus)

ROCK2 [cytosol] (Caenorhabditis elegans)

ROCK2 [cytosol] (Canis familiaris)

ROCK2 [cytosol] (Danio rerio)

ROCK2 [cytosol] (Drosophila melanogaster)

ROCK2 [cytosol] (Gallus gallus)

ROCK2 [cytosol] (Mus musculus)

ROCK2 [cytosol] (Rattus norvegicus)

ROCK2 [cytosol] (Sus scrofa)

ROCK2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001308572.1, NP_004841.2

ZINC - World Drugs

ROCK2_HUMAN

Guide to Pharmacology - Targets

1504

OpenTargets

ENSG00000134318

ZINC - FDA approved

ROCK2_HUMAN

ZINC - Substances

ROCK2_HUMAN

ZINC - Biogenic

ROCK2_HUMAN

ZINC target

O75116

PRO

O75116

PDB

7P6N, 6P5M, 4L6Q, 8GDS, 5U7Q, 7JOV, 4WOT, 7JNT, 6ED6, 5U7R, 6P5P

ZINC - Investigational

ROCK2_HUMAN

HPA

ENSG00000134318-ROCK2

GeneCards

O75116

Ensembl

ENSG00000134318, ENST00000315872, ENSP00000317985

Pharos - Targets

O75116

ZINC - Predictions - Purchasable

ROCK2_HUMAN

HMDB Protein

HMDBP01518

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	6
UniProt:O15530 PDPK1	3	p-S241-PDPK1 [cytosol] (R-HSA-9860799) PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.527	2
UniProt:Q13464 ROCK1	6	ROCK1 [extracellular region] (R-HSA-6806527) ROCK1 [secretory granule lumen] (R-HSA-6804967) Activated ROCK1 [cytosol] (R-HSA-4687777) ROCK1(1114-1354) [cytosol] (R-HSA-212524) ROCK1(1-1113) [cytosol] (R-HSA-212523) ROCK1 [cytosol] (R-HSA-212509)	0.527	2
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.527	2
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.524	3