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PPP1R12A [cytosol]
Stable Identifier
R-HSA-419070
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MYPT1, Protein phosphatase 1 regulatory subunit 12A, Myosin phosphatase-targeting subunit 1, MYPT1_HUMAN, Protein phosphatase myosin-binding subunit
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate ROCKs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12A [cytosol] (Homo sapiens)
Myosin phosphatase inactivation by ROCK (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12A [cytosol] (Homo sapiens)
RHO GTPases activate CIT (Homo sapiens)
Activated CIT phosphorylates MRLCs (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12A [cytosol] (Homo sapiens)
RHO GTPases activate PAKs (Homo sapiens)
MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12A [cytosol] (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12A [cytosol] (Homo sapiens)
PAK1 phosphorylates myosin phosphatase (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12A [cytosol] (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12A [cytosol] (Homo sapiens)
p-T38-PPP1R14A binds MLCP (Homo sapiens)
MLCP:p-T38-PPP1R14A [cytosol] (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12A [cytosol] (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14974 PPP1R12A
Gene Names
PPP1R12A, MBS, MYPT1
Chain
chain:1-1030
Reference Genes
BioGPS Gene:4659 PPP1R12A
COSMIC (genes):PPP1R12A PPP1R12A
CTD Gene:4659 PPP1R12A
dbSNP Gene:4659 PPP1R12A
ENSEMBL:ENSG00000058272 PPP1R12A
HGNC:7618 PPP1R12A
KEGG:hsa:4659 PPP1R12A
Monarch:4659 PPP1R12A
NCBI Gene:4659 PPP1R12A
OMIM:602021 PPP1R12A
UCSC:O14974 PPP1R12A
Reference Transcript
RefSeq:NM_001244992.1 PPP1R12A
RefSeq:NM_001244990.1 PPP1R12A
RefSeq:NM_002480.2 PPP1R12A
RefSeq:NM_001143886.1 PPP1R12A
RefSeq:NM_001143885.1 PPP1R12A
RefSeq:XM_011538383.2 PPP1R12A
Other Identifiers
11733074_s_at
11733075_a_at
11733076_x_at
11733077_a_at
11733078_a_at
16767932
201602_PM_s_at
201602_s_at
201603_PM_at
201603_at
201604_PM_s_at
201604_s_at
3463569
3463570
3463572
3463573
3463574
3463575
3463578
3463579
3463580
3463581
3463582
3463584
3463585
3463586
3463587
3463590
3463593
3463594
3463595
3463596
3463597
3463598
3463599
3463600
3463601
3463603
3463605
3463606
3463607
3463608
3463609
3463610
3463613
3463614
3463615
3463618
3463620
3463621
3463623
3463627
3463628
3463629
3463631
3463632
3463641
3463651
3463652
3463653
3463654
40438_at
4659
79022_at
7965123
A_23_P204564
A_24_P364412
A_24_P56252
GE499062
GE57421
GO:0000278
GO:0000776
GO:0001725
GO:0004857
GO:0005515
GO:0005654
GO:0005730
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0006355
GO:0006470
GO:0007098
GO:0007165
GO:0015629
GO:0019208
GO:0019901
GO:0030018
GO:0030155
GO:0031672
GO:0035507
GO:0035508
GO:0043086
GO:0043226
GO:0043292
GO:0045944
GO:0046822
GO:0071466
GO:0071889
GO:0072357
GO:0098772
HMNXSV003029505
HMNXSV003055085
Hs.16533.0.S1_3p_a_at
Hs.16533.0.S3_3p_at
PH_hs_0024292
TC12001766.hg
g4505316_3p_a_at
Participates
as a component of
Myosin phosphatase [cytosol] (Homo sapiens)
Other forms of this molecule
p-T696-PPP1R12A [cytosol]
p-T696,S852-PPP1R12A [cytosol]
p-S473-PPP1R12A [nucleoplasm]
Inferred To
Mbs [cytosol]
(Drosophila melanogaster)
PPP1R12A [cytosol]
(Bos taurus)
PPP1R12A [cytosol]
(Canis familiaris)
PPP1R12A [cytosol]
(Gallus gallus)
PPP1R12A [cytosol]
(Sus scrofa)
mel-11 [cytosol]
(Caenorhabditis elegans)
ppp1r12a [cytosol]
(Danio rerio)
ppp1r12a [cytosol]
(Xenopus tropicalis)
Ppp1r12a [cytosol]
(Mus musculus)
Ppp1r12a [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_002471.1
,
XP_011536685.1
,
NP_001231921.1
,
NP_001231919.1
,
NP_001137357.1
,
NP_001137358.1
OpenTargets
ENSG00000058272
ENSEMBL
ENST00000550107
,
ENST00000546369
,
ENST00000450142
,
ENSP00000446855
,
ENSP00000389168
,
ENSP00000261207
,
ENST00000261207
,
ENSP00000449514
,
ENSP00000416769
,
ENST00000437004
HPA
ENSG00000058272-PPP1R12A
PRO
O14974
Pharos - Targets
O14974
GlyGen
O14974
PDB
2KJY
,
5HUZ
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
13
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.564
2
UniProt:O18734
2
phospho-CPI17 [cytosol]
(R-SSC-5671764)
CPI17 [cytosol]
(R-SSC-5671761)
0.544
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.483
2
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