GEFs activate RhoA,B,C

Stable Identifier
R-HSA-419166
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Guanine nucleotide exchange factors (GEFs) activate GTPases by enhancing the exchange of bound GDP for GTP. Much evidence points to GEFs being critical mediators of Rho GTPase activation (Schmidt and Hall, 2002). Many GEFs are known to be highly specific for a particular GTPase, e.g. Fgd1/Cdc42 and p115RhoGEF/Rho (Hart et al., 1996, Zheng et al., 1996). Others have a broader spectrum and activate several GTPases, e.g. Vav1 for Rac, Rho, and Cdc42 (Hart et al, 1994).
Literature References
PubMed ID Title Journal Year
9308960 Rho GTPases and signaling networks

D'Souza-Schorey, C, Van Aelst, L

Genes Dev 1997
16212495 Rho GTPases: biochemistry and biology

Hall, A, Jaffe, AB

Annu Rev Cell Dev Biol 2005
12101119 Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

Hall, A, Schmidt, A

Genes Dev 2002
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of GEFs [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!