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PAF receptor binds platelet activating factor
Stable Identifier
R-HSA-419351
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
PAF receptor binds platelet activating factor (Homo sapiens)
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Platelet-activating factor (PAF, AGEPC, acetyl-glyceryl-ether-phosphorylcholine) is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis. It is an important mediator of bronchoconstriction. It causes platelets to aggregate and blood vessels to dilate so is important to the process of hemostasis. The PAF receptor (Ye RD et al, 1991) shows structural characteristics of the rhodopsin gene family and binds platelet-activating factor (PAF). The activity of this receptor is mediated by coupling with the G protein alpha q subunit which stimulates PLC-beta which can cleave PIP2 to form secondary messengers (Deo DD et al, 2004).
Literature References
PubMed ID
Title
Journal
Year
14617636
Activation of platelet-activating factor receptor-coupled G alpha q leads to stimulation of Src and focal adhesion kinase via two separate pathways in human umbilical vein endothelial cells
Hunt, JD
,
Bazan, NG
,
Deo, DD
J Biol Chem
2004
1656963
Characterization of a human cDNA that encodes a functional receptor for platelet activating factor
Cochrane, CG
,
Ye, RD
,
Zou, AH
,
Prossnitz, ER
Biochem Biophys Res Commun
1991
Participants
Input
PAF [extracellular region]
PTAFR [plasma membrane]
(Homo sapiens)
Output
PAF receptor:PAF [plasma membrane]
(Homo sapiens)
Participates
as an event of
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Orthologous Events
PAF receptor binds platelet activating factor (Bos taurus)
PAF receptor binds platelet activating factor (Canis familiaris)
PAF receptor binds platelet activating factor (Danio rerio)
PAF receptor binds platelet activating factor (Gallus gallus)
PAF receptor binds platelet activating factor (Mus musculus)
PAF receptor binds platelet activating factor (Rattus norvegicus)
PAF receptor binds platelet activating factor (Sus scrofa)
PAF receptor binds platelet activating factor (Xenopus tropicalis)
Authored
Jassal, B (2009-04-30)
Reviewed
D'Eustachio, P (2009-05-29)
Created
Jassal, B (2009-04-30)
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