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LPAR1 [plasma membrane]
Stable Identifier
R-HSA-419354
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Lysophosphatidic acid receptor 1, LPAR1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Lysosphingolipid and LPA receptors (Homo sapiens)
LPA-binding receptors bind LPA (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92633 LPAR1
Gene Names
LPAR1, EDG2, LPA1
Chain
chain:1-364
Reference Genes
BioGPS Gene:1902 LPAR1
COSMIC (genes):LPAR1 LPAR1
CTD Gene:1902 LPAR1
dbSNP Gene:1902 LPAR1
ENSEMBL:ENSG00000198121 LPAR1
HGNC:3166 LPAR1
KEGG Gene (Homo sapiens):1902 LPAR1
Monarch:1902 LPAR1
NCBI Gene:1902 LPAR1
OMIM:602282 LPAR1
UCSC:Q92633 LPAR1
Reference Transcript
RefSeq:XM_017014403.1 LPAR1
RefSeq:XM_017014385.1 LPAR1
RefSeq:XM_017014394.1 LPAR1
RefSeq:XM_017014401.1 LPAR1
RefSeq:XM_017014384.1 LPAR1
RefSeq:XM_017014393.1 LPAR1
RefSeq:XM_017014402.1 LPAR1
RefSeq:XM_017014396.1 LPAR1
RefSeq:XM_017014387.1 LPAR1
RefSeq:XM_017014405.1 LPAR1
RefSeq:XM_017014395.1 LPAR1
RefSeq:XM_017014386.1 LPAR1
RefSeq:XM_017014404.1 LPAR1
RefSeq:XM_017014389.1 LPAR1
RefSeq:XM_017014398.1 LPAR1
RefSeq:XM_017014407.1 LPAR1
RefSeq:XM_017014397.1 LPAR1
RefSeq:XM_017014406.1 LPAR1
RefSeq:XM_017014388.1 LPAR1
RefSeq:NM_001401.3 LPAR1
RefSeq:NM_057159.2 LPAR1
RefSeq:XM_017014391.1 LPAR1
RefSeq:XM_017014400.1 LPAR1
RefSeq:XM_017014383.1 LPAR1
RefSeq:XM_017014392.1 LPAR1
RefSeq:XM_017014399.1 LPAR1
RefSeq:XM_005251781.3 LPAR1
RefSeq:XM_017014390.1 LPAR1
RefSeq:XM_005251782.3 LPAR1
Other Identifiers
0005390707
11729750_a_at
11729751_a_at
11746409_a_at
11747839_a_at
17097132
1902
204036_at
204037_at
204038_s_at
3220385
3220386
3220387
3220388
3220389
3220390
3220391
3220411
3220414
3220415
3220416
3220417
3220422
3220435
3220436
40387_at
52170_at
77817_r_at
8163257
A_23_P502879
A_33_P3383326
GE59467
GE86272
GO:0000902
GO:0003674
GO:0004930
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005768
GO:0005886
GO:0005887
GO:0006464
GO:0007010
GO:0007165
GO:0007186
GO:0007189
GO:0007193
GO:0007202
GO:0007204
GO:0008150
GO:0008289
GO:0008360
GO:0009986
GO:0010977
GO:0016020
GO:0016021
GO:0019222
GO:0022008
GO:0022607
GO:0030139
GO:0030154
GO:0031410
GO:0035025
GO:0035727
GO:0040011
GO:0042592
GO:0043123
GO:0043167
GO:0043226
GO:0043410
GO:0048856
GO:0048870
GO:0051482
GO:0051496
GO:0060326
GO:0070915
HMNXSV003038033
Hs.75794.0.A3_3p_at
Hs.75794.0.A4_3p_at
ILMN_1674984
ILMN_1701441
PH_hs_0027687
TC09001478.hg
U80811_at
g4503456_3p_a_at
Participates
as a member of
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
Inferred To
lpar1 [plasma membrane]
(Danio rerio)
lpar1 [plasma membrane]
(Xenopus tropicalis)
Lpar1 [plasma membrane]
(Mus musculus)
Lpar1 [plasma membrane]
(Rattus norvegicus)
LPAR1 [plasma membrane]
(Bos taurus)
LPAR1 [plasma membrane]
(Canis familiaris)
LPAR1 [plasma membrane]
(Gallus gallus)
LPAR1 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
XP_016869873.1
,
XP_016869893.1
,
XP_016869874.1
,
XP_016869892.1
,
XP_016869889.1
,
XP_005251839.1
,
XP_016869888.1
,
XP_016869880.1
,
XP_016869887.1
,
XP_016869876.1
,
XP_016869895.1
,
XP_016869875.1
,
XP_016869894.1
,
XP_016869882.1
,
XP_016869881.1
,
XP_016869878.1
,
XP_016869877.1
,
XP_016869896.1
,
NP_001392.2
,
XP_016869884.1
,
XP_016869883.1
,
XP_016869891.1
,
XP_016869879.1
,
XP_016869872.1
,
XP_016869890.1
,
NP_476500.1
,
XP_016869886.1
,
XP_005251838.1
,
XP_016869885.1
Guide to Pharmacology - Targets
272
OpenTargets
ENSG00000198121
ZINC - Substances
LPAR1_HUMAN
ZINC target
Q92633
ZINC - Biogenic
LPAR1_HUMAN
PRO
Q92633
GlyGen
Q92633
PDB
4Z36
,
4Z34
,
4Z35
ZINC - Investigational
LPAR1_HUMAN
ZINC - Metabolites
LPAR1_HUMAN
GeneCards
Q92633
HPA
ENSG00000198121-LPAR1
Ensembl
ENSP00000363553
,
ENSP00000363552
,
ENSG00000198121
,
ENSP00000351755
,
ENST00000374430
,
ENST00000374431
,
ENST00000358883
Pharos - Targets
Q92633
Orphanet
24681
ZINC - Predictions - Purchasable
LPAR1_HUMAN
HMDB Protein
HMDBP02852
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