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LPAR1 [plasma membrane]
Stable Identifier
R-HSA-419354
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Lysophosphatidic acid receptor 1, LPAR1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Lysosphingolipid and LPA receptors (Homo sapiens)
LPA-binding receptors bind LPA (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
LPAR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92633 LPAR1
Gene Names
LPAR1, EDG2, LPA1
Chain
chain:1-364
Reference Genes
BioGPS Gene:1902 LPAR1
COSMIC (genes):LPAR1 LPAR1
CTD Gene:1902 LPAR1
dbSNP Gene:1902 LPAR1
ENSEMBL:ENSG00000198121 LPAR1
HGNC:3166 LPAR1
KEGG:hsa:1902 LPAR1
Monarch:1902 LPAR1
NCBI Gene:1902 LPAR1
OMIM:602282 LPAR1
UCSC:Q92633 LPAR1
Reference Transcript
RefSeq:NM_001351416.2 LPAR1
RefSeq:NM_001387492.1 LPAR1
RefSeq:NM_001387490.1 LPAR1
RefSeq:XM_017014394.1 LPAR1
RefSeq:NM_001387488.1 LPAR1
RefSeq:XM_017014403.1 LPAR1
RefSeq:XM_017014396.1 LPAR1
RefSeq:XM_017014404.1 LPAR1
RefSeq:NM_001387497.1 LPAR1
RefSeq:XM_005251782.3 LPAR1
RefSeq:NM_001387510.1 LPAR1
RefSeq:NM_001351418.2 LPAR1
RefSeq:XM_017014387.1 LPAR1
RefSeq:NM_001387485.1 LPAR1
RefSeq:NM_001351417.2 LPAR1
RefSeq:NM_001351420.2 LPAR1
RefSeq:NM_001387480.1 LPAR1
RefSeq:NM_001387471.1 LPAR1
RefSeq:NM_001351409.2 LPAR1
RefSeq:XM_017014385.1 LPAR1
RefSeq:NM_001401.3 LPAR1
RefSeq:NM_001387511.1 LPAR1
RefSeq:NM_001351410.2 LPAR1
RefSeq:NM_001387502.1 LPAR1
RefSeq:NM_001351403.2 LPAR1
RefSeq:NM_001351407.2 LPAR1
RefSeq:XM_017014400.1 LPAR1
RefSeq:NM_001387512.1 LPAR1
RefSeq:NM_001387489.1 LPAR1
RefSeq:XM_017014401.1 LPAR1
RefSeq:NM_001387514.1 LPAR1
RefSeq:NM_001387494.1 LPAR1
RefSeq:XM_017014405.1 LPAR1
RefSeq:XM_017014407.1 LPAR1
RefSeq:NM_001351419.2 LPAR1
RefSeq:NM_001351413.2 LPAR1
RefSeq:NM_001387479.1 LPAR1
RefSeq:NM_001351397.2 LPAR1
RefSeq:NM_001387475.1 LPAR1
RefSeq:NM_001351398.2 LPAR1
RefSeq:NM_001387503.1 LPAR1
RefSeq:NM_001351408.2 LPAR1
RefSeq:XM_017014383.1 LPAR1
RefSeq:XM_017014393.1 LPAR1
RefSeq:NM_001387477.1 LPAR1
RefSeq:NM_001387474.1 LPAR1
RefSeq:NM_001387506.1 LPAR1
RefSeq:NM_001387498.1 LPAR1
RefSeq:NM_001387470.1 LPAR1
RefSeq:XM_017014389.1 LPAR1
RefSeq:NM_001387484.1 LPAR1
RefSeq:NM_001351414.2 LPAR1
RefSeq:NM_001387515.1 LPAR1
RefSeq:XM_047422903.1 LPAR1
RefSeq:XM_017014397.1 LPAR1
RefSeq:NM_001351411.2 LPAR1
RefSeq:NM_001387496.1 LPAR1
RefSeq:NM_057159.4 LPAR1
RefSeq:NM_001387481.1 LPAR1
RefSeq:XM_017014392.1 LPAR1
RefSeq:NM_001351415.2 LPAR1
RefSeq:XM_017014386.1 LPAR1
RefSeq:NM_001387493.1 LPAR1
RefSeq:NM_001387509.1 LPAR1
RefSeq:NM_001351402.2 LPAR1
RefSeq:NM_001387473.1 LPAR1
RefSeq:XM_005251781.3 LPAR1
RefSeq:NM_001387507.1 LPAR1
RefSeq:NM_001387478.1 LPAR1
RefSeq:NM_001387513.1 LPAR1
RefSeq:XM_017014388.1 LPAR1
RefSeq:NM_001351401.2 LPAR1
RefSeq:NM_001387487.1 LPAR1
RefSeq:XM_017014384.1 LPAR1
RefSeq:NM_001387486.1 LPAR1
RefSeq:XM_017014399.1 LPAR1
RefSeq:NM_001387505.1 LPAR1
RefSeq:NM_001387476.1 LPAR1
RefSeq:NM_001351404.2 LPAR1
RefSeq:NM_001387501.1 LPAR1
RefSeq:NM_001387508.1 LPAR1
RefSeq:NM_001351412.2 LPAR1
RefSeq:XM_017014390.1 LPAR1
RefSeq:NM_001387504.1 LPAR1
RefSeq:NM_001351400.2 LPAR1
RefSeq:XM_017014402.1 LPAR1
RefSeq:NM_001351399.2 LPAR1
RefSeq:NM_001351405.2 LPAR1
RefSeq:NM_001387483.1 LPAR1
RefSeq:XM_017014398.1 LPAR1
RefSeq:XM_017014406.1 LPAR1
RefSeq:NM_001387482.1 LPAR1
RefSeq:XM_017014395.1 LPAR1
RefSeq:NM_001351406.2 LPAR1
RefSeq:NM_001387495.1 LPAR1
RefSeq:NM_001387491.1 LPAR1
RefSeq:NM_001387472.1 LPAR1
RefSeq:XM_017014391.1 LPAR1
Other Identifiers
11729750_a_at
11729751_a_at
11746409_a_at
11747839_a_at
17097132
1902
204036_PM_at
204036_at
204037_PM_at
204037_at
204038_PM_s_at
204038_s_at
3220385
3220386
3220387
3220388
3220389
3220390
3220391
3220409
3220410
3220411
3220414
3220415
3220416
3220417
3220422
3220434
3220435
3220436
3220437
3220438
40387_at
52170_at
77817_r_at
8163257
A_23_P502879
A_33_P3383326
GE59467
GE86272
GO:0001965
GO:0004930
GO:0005515
GO:0005543
GO:0005737
GO:0005768
GO:0005886
GO:0007186
GO:0007189
GO:0007193
GO:0007200
GO:0007204
GO:0008289
GO:0008360
GO:0009986
GO:0010977
GO:0014003
GO:0016020
GO:0019222
GO:0021549
GO:0021554
GO:0022008
GO:0022038
GO:0030139
GO:0030154
GO:0030165
GO:0031410
GO:0032060
GO:0035025
GO:0035727
GO:0042552
GO:0042734
GO:0043025
GO:0043065
GO:0043123
GO:0043197
GO:0043198
GO:0043226
GO:0043410
GO:0045211
GO:0048856
GO:0048870
GO:0051496
GO:0060089
GO:0060326
GO:0060999
GO:0070915
GO:0071453
GO:0071673
GO:0098693
GO:0098978
GO:0098982
GO:0099149
GO:0141162
GO:1902018
GO:1904566
HMNXSV003038033
Hs.75794.0.A3_3p_at
Hs.75794.0.A4_3p_at
ILMN_1674984
ILMN_1701441
ILMN_1791242
PH_hs_0027687
TC09001478.hg
U80811_at
g4503456_3p_a_at
Participates
as a member of
LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
Inferred To
lpar1 [plasma membrane]
(Danio rerio)
lpar1 [plasma membrane]
(Xenopus tropicalis)
Lpar1 [plasma membrane]
(Mus musculus)
Lpar1 [plasma membrane]
(Rattus norvegicus)
LPAR1 [plasma membrane]
(Bos taurus)
LPAR1 [plasma membrane]
(Canis familiaris)
LPAR1 [plasma membrane]
(Gallus gallus)
LPAR1 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001338344.1
,
NP_001392.2
,
XP_016869896.1
,
NP_001338334.1
,
NP_001374442.1
,
NP_001374418.1
,
NP_001374427.1
,
NP_001374400.1
,
NP_001338342.1
,
XP_016869882.1
,
NP_001374421.1
,
NP_001374411.1
,
XP_016869881.1
,
XP_016869886.1
,
NP_001374406.1
,
XP_016869892.1
,
NP_001338337.1
,
NP_001374437.1
,
NP_001338349.1
,
NP_001374419.1
,
XP_005251839.1
,
NP_001374436.1
,
XP_016869876.1
,
NP_001338331.1
,
NP_001374422.1
,
NP_001374403.1
,
NP_001374409.1
,
NP_001374416.1
,
XP_016869874.1
,
XP_016869890.1
,
NP_001374440.1
,
NP_001374431.1
,
NP_001374412.1
,
NP_001338348.1
,
NP_001374423.1
,
NP_001374444.1
,
NP_001374415.1
,
XP_016869880.1
,
XP_016869872.1
,
NP_001374420.1
,
XP_016869887.1
,
NP_001338338.1
,
NP_001374441.1
,
XP_016869875.1
,
XP_016869879.1
,
NP_001374439.1
,
XP_005251838.1
,
XP_016869889.1
,
NP_001338327.1
,
NP_001338340.1
,
NP_001374435.1
,
XP_016869894.1
,
NP_001374408.1
,
NP_001338330.1
,
NP_001374417.1
,
XP_016869888.1
,
NP_001338333.1
,
NP_001374410.1
,
NP_001338335.1
,
NP_001374413.1
,
NP_001374405.1
,
NP_001338326.1
,
NP_001374401.1
,
XP_016869893.1
,
NP_001338347.1
,
XP_016869885.1
,
NP_001374404.1
,
XP_016869873.1
,
XP_016869877.1
,
NP_001374399.1
,
NP_001374430.1
,
NP_001374434.1
,
NP_001374402.1
,
XP_047278859.1
,
NP_001338346.1
,
NP_001374433.1
,
NP_476500.1
,
NP_001374414.1
,
NP_001374425.1
,
NP_001374432.1
,
NP_001374424.1
,
NP_001338336.1
,
XP_016869878.1
,
XP_016869891.1
,
NP_001338339.1
,
XP_016869884.1
,
NP_001338345.1
,
NP_001374438.1
,
XP_016869895.1
,
NP_001338329.1
,
NP_001374407.1
,
NP_001374426.1
,
XP_016869883.1
,
NP_001338343.1
,
NP_001374443.1
,
NP_001338328.1
,
NP_001338341.1
,
NP_001338332.1
Guide to Pharmacology - Targets
272
OpenTargets
ENSG00000198121
ENSEMBL
ENSP00000363552
,
ENSP00000363553
,
ENST00000683809
,
ENSP00000506912
,
ENSP00000351755
,
ENST00000374430
,
ENSG00000198121
,
ENST00000358883
,
ENST00000374431
ZINC - Substances
LPAR1_HUMAN
ZINC - Biogenic
LPAR1_HUMAN
ZINC target
Q92633
PRO
Q92633
GlyGen
Q92633
PDB
7YU8
,
7YU7
,
7YU5
,
7YU3
,
4Z35
,
4Z34
,
4Z36
,
7YU6
,
7YU4
,
7TD1
,
9J5V
,
7TD2
,
7TD0
ZINC - Investigational
LPAR1_HUMAN
ZINC - Metabolites
LPAR1_HUMAN
HPA
ENSG00000198121-LPAR1
GeneCards
LPAR1
Pharos - Targets
Q92633
ZINC - Predictions - Purchasable
LPAR1_HUMAN
HMDB Protein
HMDBP02852
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NTJ5 SACM1L
2
SACM1L [endoplasmic reticulum membrane]
(R-HSA-1604637)
SACM1L [Golgi membrane]
(R-HSA-1806242)
0.643
3
UniProt:A0PJW6 TMEM223
1
TMEM223 [mitochondrial inner membrane]
(R-HSA-9865797)
0.527
2
UniProt:Q96PC5 MIA2
1
MIA2 [endoplasmic reticulum membrane]
(R-HSA-9637821)
0.527
2
UniProt:P17152 TMEM11
1
TMEM11 [mitochondrial inner membrane]
(R-HSA-8949578)
0.527
2
UniProt:P48960 ADGRE5
2
CD97(21-835) [secretory granule membrane]
(R-HSA-6803297)
CD97 [plasma membrane]
(R-HSA-444764)
0.527
3
UniProt:Q9BQ95 ECSIT
2
ECSIT [cytosol]
(R-HSA-168064)
ECSIT [mitochondrial inner membrane]
(R-HSA-5689047)
0.527
3
UniProt:O43909 EXTL3
2
EXTL3 [Golgi membrane]
(R-HSA-9941179)
EXTL3 [endoplasmic reticulum membrane]
(R-HSA-535476)
0.527
2
UniProt:Q15800 MSMO1
1
MSMO1 [endoplasmic reticulum membrane]
(R-HSA-194648)
0.527
2
UniProt:Q9H8X2 IPPK
2
IPPK [cytosol]
(R-HSA-1604598)
IPPK [nucleoplasm]
(R-HSA-2023949)
0.527
2
UniProt:P03886 MT-ND1
1
MT-ND1 [mitochondrial inner membrane]
(R-HSA-60551)
0.527
2
UniProt:Q9H5K3 POMK
1
POMK [endoplasmic reticulum membrane]
(R-HSA-8879120)
0.527
2
UniProt:Q9HD23 MRS2
1
MRS2 [mitochondrial inner membrane]
(R-HSA-5216072)
0.527
2
UniProt:Q07065 CKAP4
7
CKAP4 [endoplasmic reticulum lumen]
(R-HSA-8956737)
p-CKAP4 [endoplasmic reticulum lumen]
(R-HSA-8956926)
CKAP4 [specific granule membrane]
(R-HSA-6799552)
CKAP4 [plasma membrane]
(R-HSA-5686306)
CKAP4 [azurophil granule membrane]
(R-HSA-6799559)
PALM-C100-CKAP4 [plasma membrane]
(R-HSA-5686280)
PALM-C100-CKAP4 [lamellar body]
(R-HSA-5686285)
0.527
3
UniProt:Q8N6M3 FITM2
1
FITM2 [endoplasmic reticulum membrane]
(R-HSA-8857678)
0.527
2
UniProt:Q16581 C3AR1
3
C3AR1 [plasma membrane]
(R-HSA-444727)
C3AR1 [specific granule membrane]
(R-HSA-6799516)
C3AR1 [azurophil granule membrane]
(R-HSA-6799517)
0.527
2
UniProt:O75915 ARL6IP5
1
ARL6IP5 [cytosol]
(R-HSA-2980942)
0.527
2
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