Reactome | Lysosphingolipid and LPA receptors

Lysosphingolipid and LPA receptors

Stable Identifier

R-HSA-419408

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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The Lysophospholipid receptor (LPLR) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans there are eight LPL receptors, each encoded by a separate gene (these genes also sometimes referred to as "Edg" or endothelial differentiation gene). The ligands for LPLRs are the lysophospholipid extracellular signaling molecules, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). The primary effects are inhibition of adenylyl cyclase and release of calcium from the endoplasmic reticulum, as well as secondary effects of preventing apoptosis and increasing cell proliferation (Contos JJ et al, 2000; An S et al, 1998; Fukushima N and Chun J, 2001).

Literature References

PubMed ID	Title	Journal	Year
9893266	Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate Lee, H, An, S, Goetzl, EJ	J Cell Biochem Suppl	1998
11324705	The LPA receptors Fukushima, N, Chun, J	Prostaglandins Other Lipid Mediat	2001
11093753	Lysophosphatidic acid receptors Contos, JJ, Chun, J, Ishii, I	Mol Pharmacol	2000