Lysosphingolipid and LPA receptors

Stable Identifier
Homo sapiens
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The Lysophospholipid receptor (LPLR) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans there are eight LPL receptors, each encoded by a separate gene (these genes also sometimes referred to as "Edg" or endothelial differentiation gene). The ligands for LPLRs are the lysophospholipid extracellular signaling molecules, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). The primary effects are inhibition of adenylyl cyclase and release of calcium from the endoplasmic reticulum, as well as secondary effects of preventing apoptosis and increasing cell proliferation (Contos JJ et al, 2000; An S et al, 1998; Fukushima N and Chun J, 2001).

Literature References
PubMed ID Title Journal Year
9893266 Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate

Lee, H, An, S, Goetzl, EJ

J Cell Biochem Suppl 1998
11324705 The LPA receptors

Fukushima, N, Chun, J

Prostaglandins Other Lipid Mediat 2001
11093753 Lysophosphatidic acid receptors

Contos, JJ, Chun, J, Ishii, I

Mol Pharmacol 2000
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