Reactome | FANCC [nucleoplasm]

FANCC [nucleoplasm]

Stable Identifier

R-HSA-419530

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Fanconi anemia group C protein, FANCC_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P31749 AKT1

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
        
        TP53 stimulates FANCC expression (Homo sapiens)
        
        FANCC [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q00597 FANCC

Gene Names

FANCC, FAC, FACC

Chain

chain:1-558

Reference Genes

BioGPS Gene:2176 FANCC

COSMIC (genes):FANCC FANCC

CTD Gene:2176 FANCC

dbSNP Gene:2176 FANCC

ENSEMBL:ENSG00000158169 FANCC

HGNC:3584 FANCC

KEGG:hsa:2176 FANCC

Monarch:2176 FANCC

NCBI Gene:2176 FANCC

OMIM:613899 FANCC

UCSC:Q00597 FANCC

Reference Transcript

Other Identifiers

105376156

11721591_a_at

11721592_a_at

11756738_a_at

160034_s_at

17096054

17096088

1982_s_at

205189_PM_s_at

205189_s_at

2176

3215716

3215717

3215718

3215719

3215720

3215721

3215722

3215723

3215724

3215727

3215728

3215729

3215730

3215731

3215732

3215733

3215735

3215736

3215741

3215742

3215743

3215746

3215747

3215748

3215749

3215750

3215751

3215752

3215753

3215757

3215758

3215759

3215761

3215763

3215764

3215765

3215775

3215785

3215786

3215787

3215788

3215789

3215790

3215791

3215797

3215799

3215800

3215801

3215802

3215809

3215836

3215844

35713_at

4051844

4051848

53834_at

56891_at

72202_f_at

8162514

A_21_P0013735

A_23_P32021

A_33_P3319765

GE59932

GE697309

GO:0000785

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006281

GO:0006289

GO:0006974

GO:0034599

GO:0036297

GO:0043240

GO:0065003

HMNXSV003009246

HMNXSV003015010

HMNXSV003023258

HMNXSV003050572

ILMN_1683112

PH_hs_0023250

TC09001361.hg

TC09001365.hg

X66894_s_at

g4557588_3p_a_at

p16548

Participates

as a component of

as an input of

FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)

as an output of

TP53 stimulates FANCC expression (Homo sapiens)

Other forms of this molecule

FANCC [cytosol]

Inferred To

FANCC [nucleoplasm] (Bos taurus)

FANCC [nucleoplasm] (Canis familiaris)

FANCC [nucleoplasm] (Gallus gallus)

FANCC [nucleoplasm] (Sus scrofa)

Fancc [nucleoplasm] (Mus musculus)

Fancc [nucleoplasm] (Rattus norvegicus)

fancc [nucleoplasm] (Danio rerio)

fancc [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

XP_011516667.1, NP_000127.2, XP_047278905.1, XP_054218288.1, XP_054218286.1, XP_047278904.1, XP_054218287.1, XP_054218285.1, XP_024303219.1, NP_001230672.1

OpenTargets

ENSG00000158169

ENSEMBL

ENST00000289081, ENSG00000158169, ENST00000375305, ENSP00000289081, ENSP00000364454

HPA

ENSG00000158169-FANCC

GeneCards

FANCC

PRO

Q00597

Pharos - Targets

Q00597

Orphanet

FANCC

GlyGen

Q00597

PDB

7KZS, 7KZT, 7KZR, 7KZV, 7KZP, 7KZQ

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HB96 FANCE	2	FANCE [nucleoplasm] (R-HSA-419543) FANCE [cytosol] (R-HSA-420786)	0.783	6
UniProt:O15360 FANCA	2	FANCA [cytosol] (R-HSA-420796) FANCA [nucleoplasm] (R-HSA-419541)	0.678	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.609	4
UniProt:Q13813 SPTAN1	6	SPTAN1 [cytosol] (R-HSA-201601) SPTAN1(1-1185) [cytosol] (R-HSA-202944) SPTAN1(1186-2472) [cytosol] (R-HSA-202964) SPTAN1 [tertiary granule lumen] (R-HSA-6800874) SPTAN1 [extracellular region] (R-HSA-6806322) SPTAN1 [specific granule lumen] (R-HSA-6799533)	0.589	2
UniProt:P14625 HSP90B1	4	HSP90B1 [endocytic vesicle lumen] (R-HSA-3221623) HSP90B1 [extracellular region] (R-HSA-3221653) p-HSP90B1 [endoplasmic reticulum lumen] (R-HSA-8957016) HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.581	4
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.519	5
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.519	2
UniProt:Q969H0 FBXW7	1	FBXW7 [cytosol] (R-HSA-391304)	0.519	5
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.471	2

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