Reactome | FANCG [nucleoplasm]

FANCG [nucleoplasm]

Stable Identifier

R-HSA-419532

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Fanconi anemia group G protein, FANCG_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P15976-2 GATA1

Expand all

External Reference Information

External Reference

UniProt:O15287 FANCG

Gene Names

FANCG, XRCC9

Chain

chain:1-622

Reference Genes

BioGPS Gene:2189 FANCG

COSMIC (genes):FANCG FANCG

CTD Gene:2189 FANCG

dbSNP Gene:2189 FANCG

ENSEMBL:ENSG00000221829 FANCG

HGNC:3588 FANCG

KEGG:hsa:2189 FANCG

Monarch:2189 FANCG

NCBI Gene:2189 FANCG

OMIM:602956 FANCG

UCSC:O15287 FANCG

Reference Transcript

RefSeq:NM_004629.1 FANCG

Other Identifiers

11756256_a_at

17093595

203564_PM_at

203564_at

2189

3204120

3204440

3204441

3204464

3204465

3204466

3204467

3204468

3204469

3204470

3204471

3204472

3204473

3204474

3204475

3204476

3204477

3204478

3204479

3204480

3204481

3204482

3204483

3204485

3204486

3204487

3204488

3204489

3204490

3204491

3204492

3204493

3204494

3204495

37584_at

8160935

A_23_P71644

GE55181

GO:0000785

GO:0001541

GO:0003677

GO:0003684

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006281

GO:0006974

GO:0007005

GO:0007286

GO:0009314

GO:0022414

GO:0036297

GO:0043226

GO:0043240

GO:0048856

HMNXSV003030302

ILMN_1758728

PH_hs_0025352

TC09001049.hg

g4759335_3p_at

Participates

as a component of

as an input of

FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)

Other forms of this molecule

FANCG [cytosol]

Inferred To

fancg [nucleoplasm] (Xenopus tropicalis)

FANCG [nucleoplasm] (Bos taurus)

FANCG [nucleoplasm] (Canis familiaris)

FANCG [nucleoplasm] (Gallus gallus)

FANCG [nucleoplasm] (Sus scrofa)

Fancg [nucleoplasm] (Mus musculus)

Fancg [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_004620.1

OpenTargets

ENSG00000221829

ENSEMBL

ENSP00000367910, ENSP00000409607, ENST00000448890, ENST00000378643

HPA

ENSG00000221829-FANCG

PRO

O15287

Pharos - Targets

O15287

Orphanet

FANCG

PDB

7KZV, 7KZR, 7KZS, 7KZT, 7KZP, 7KZQ

Interactors (55)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15360 FANCA	2	FANCA [cytosol] (R-HSA-420796) FANCA [nucleoplasm] (R-HSA-419541)	0.961	26
UniProt:Q9NPI8 FANCF	2	FANCF [cytosol] (R-HSA-420794) FANCF [nucleoplasm] (R-HSA-419537)	0.75	6
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.556	3
UniProt:P08684 CYP3A4	1	CYP3A4 [endoplasmic reticulum membrane] (R-HSA-52639)	0.556	3
UniProt:Q99633 PRPF18	1	PRPF18 [nucleoplasm] (R-HSA-5688093)	0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P29474 NOS3	9	2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) MyrG-NOS3 [cytosol] (R-HSA-203687) MyrG-NOS3 [Golgi membrane] (R-HSA-534995) NOS3 [cytosol] (R-HSA-202114) 2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) 2xPalmC-MyrG-p-S633-NOS3 [plasma membrane] (R-HSA-9861341) 2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane] (R-HSA-9860783)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:P16284 PECAM1	5	PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:P20339 RAB5A	7	RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257) RAB5A [early endosome membrane] (R-HSA-2130175) GGC-RAB5A [cytosol] (R-HSA-8870432) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125)	0.556	3
UniProt:Q92870-2 Q928702			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:P14079 TAX			0.556	3
UniProt:P60891 PRPS1	1	PRPS1 [cytosol] (R-HSA-73483)	0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:Q8N8B7-2 TCEANC			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:Q8N7U7-2 TPRX1			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q13393 PLD1	4	PLD1 [tertiary granule membrane] (R-HSA-6800955) PLD1 [specific granule membrane] (R-HSA-6799531) PLD1 [plasma membrane] (R-HSA-2028998) PLD1 [endoplasmic reticulum membrane] (R-HSA-1498795)	0.556	3
UniProt:Q86UD4 ZN329			0.556	3
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.556	3
UniProt:Q9BVL2 NUP58			0.556	3
UniProt:P51687 SUOX	1	SUOX [mitochondrial matrix] (R-HSA-1614570)	0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.553	2
UniProt:P08727 KRT19	1	KRT19 [cytosol] (R-HSA-6809617)	0.553	2
UniProt:Q8N6Y0 USBP1			0.553	2
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.527	2
UniProt:P06028 GYPB	1	GYPB [plasma membrane] (R-HSA-8867209)	0.527	2
UniProt:O43252 PAPSS1	3	PAPSS1 [cytosol] (R-HSA-174387) PAPSS1(1-223)-BRAF(381-766) fusion [cytosol] (R-HSA-6802432) PAPSS1(1-223)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802543)	0.527	2
UniProt:Q9H0L4 CSTF2T	1	CSTF2T [nucleoplasm] (R-HSA-8938786)	0.527	2
UniProt:P32970 CD70	1	CD70 [plasma membrane] (R-HSA-5667139)	0.527	3
UniProt:P16444 DPEP1	1	DPEP1 [plasma membrane] (R-HSA-2142820)	0.527	3
UniProt:Q13813 SPTAN1	6	SPTAN1 [cytosol] (R-HSA-201601) SPTAN1(1-1185) [cytosol] (R-HSA-202944) SPTAN1(1186-2472) [cytosol] (R-HSA-202964) SPTAN1 [specific granule lumen] (R-HSA-6799533) SPTAN1 [extracellular region] (R-HSA-6806322) SPTAN1 [tertiary granule lumen] (R-HSA-6800874)	0.508	4
UniProt:P15976-2 GATA1			0.488	2
UniProt:Q8IYA8 IHO1			0.488	2
UniProt:O15360-3 O153603			0.488	5
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.488	2
UniProt:P13646 KRT13	1	KRT13 [cytosol] (R-HSA-6809591)	0.488	2
UniProt:Q08117-2 TLE5			0.488	2
UniProt:Q9Y2V7 COG6	2	COG6 [trans-Golgi network membrane] (R-HSA-6813872) COG6 [Golgi membrane] (R-HSA-2980958)	0.488	2
UniProt:Q7Z6G3-2 NECAB2			0.488	2
UniProt:Q8NA61-2 CBY2			0.488	2
UniProt:Q9Y2K1 ZBTB1			0.488	2
UniProt:Q9UKT9 IKZF3			0.488	2
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.488	2
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:Q8N448 LNX2			0.488	2
IntAct:EBI-11742485 SSX2IP			0.488	2

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