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FANCM [nucleoplasm]
Stable Identifier
R-HSA-419535
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Fanconi anemia group M protein, FANCM_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Fanconi Anemia Pathway (Homo sapiens)
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FANCM:FAAP24:APITD1:STRA13:ICL-DNA [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FANCM binds FAAP24 (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FANCM:FAAP24:APITD1:STRA13:ICL-DNA [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
POLN binds ICL-DNA (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
The complex of ATR and ATRIP is recruited to ICL-DNA (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
Translesion synthesis across unhooked ICL by POLN (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IYD8 FANCM
Gene Names
FANCM, KIAA1596
Chain
chain:1-2048
Reference Genes
BioGPS Gene:57697 FANCM
COSMIC (genes):FANCM FANCM
CTD Gene:57697 FANCM
dbSNP Gene:57697 FANCM
ENSEMBL:ENSG00000187790.12 FANCM
HGNC:23168 FANCM
KEGG Gene (Homo sapiens):57697 FANCM
Monarch:57697 FANCM
NCBI Gene:57697 FANCM
OMIM:609644 FANCM
UCSC:Q8IYD8 FANCM
Reference Transcript
RefSeq:NM_001308133.1 FANCM
RefSeq:NM_001308134.1 FANCM
RefSeq:NM_020937.3 FANCM
Other Identifiers
11745367_a_at
11755555_a_at
11755761_a_at
1554277_PM_s_at
1554277_s_at
16783836
231971_PM_at
231971_at
234733_PM_s_at
234733_s_at
242711_PM_x_at
242711_x_at
3534249
3534250
3534251
3534253
3534254
3534257
3534259
3534260
3534261
3534263
3534264
3534265
3534267
3534269
3534270
3534271
3534272
3534276
3534277
3534278
3534279
3534280
3534282
3534283
3534284
3534285
3534286
3534287
3534292
3534293
3534295
3534296
3534298
3534299
3534300
53645_at
53650_s_at
57697
66557_at
7974166
A_23_P404211
A_32_P106732
A_32_P79504
GE55868
GO:0000166
GO:0000400
GO:0000712
GO:0000785
GO:0003676
GO:0003677
GO:0003682
GO:0003724
GO:0003824
GO:0004386
GO:0004518
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0006260
GO:0006281
GO:0006310
GO:0006974
GO:0007059
GO:0009378
GO:0016787
GO:0016887
GO:0022414
GO:0031297
GO:0032508
GO:0036211
GO:0036297
GO:0043138
GO:0043226
GO:0043240
GO:0045003
GO:0071821
GO:0071932
GO:0090305
GO:0140013
GO:0140097
GO:0140098
GO:0140657
GO:1902527
HMNXSV003022319
Hs.280974.0.A1_3p_s_at
Hs.62717.0.S1_3p_at
Hs.62717.1.S1_3p_a_at
Hs2.371950.1.S1_3p_s_at
ILMN_1811995
PH_hs_0025225
TC14000266.hg
Participates
as a component of
FA core complex [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
as an input of
FANCM binds FAAP24 (Homo sapiens)
Other forms of this molecule
p-S1045-FANCM [nucleoplasm]
Inferred To
fancm [nucleoplasm]
(Xenopus tropicalis)
FANCM [nucleoplasm]
(Bos taurus)
FANCM [nucleoplasm]
(Canis familiaris)
FANCM [nucleoplasm]
(Dictyostelium discoideum)
FANCM [nucleoplasm]
(Mus musculus)
FANCM [nucleoplasm]
(Saccharomyces cerevisiae)
FANCM [nucleoplasm]
(Schizosaccharomyces pombe)
FANCM [nucleoplasm]
(Sus scrofa)
Fancm [nucleoplasm]
(Drosophila melanogaster)
Fancm [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of FANCM [nucleoplasm]
(Danio rerio)
Ghost homologue of FANCM [nucleoplasm]
(Gallus gallus)
Cross References
RefSeq
NP_065988.1
,
NP_001295063.1
,
NP_001295062.1
OpenTargets
ENSG00000187790
HPA
ENSG00000187790-FANCM
GeneCards
Q8IYD8
Ensembl
ENST00000542564
,
ENST00000267430
,
ENST00000556036
,
ENSP00000450596
,
ENSP00000442493
,
ENSG00000187790
,
ENSP00000267430
PRO
Q8IYD8
Pharos - Targets
Q8IYD8
Orphanet
16028
HMDB Protein
HMDBP11735
PDB
4DAY
,
4DRB
,
4BXO
,
4E45
,
4M6W
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BTP7 FAAP24
1
FAAP24 [nucleoplasm]
(R-HSA-419533)
0.671
10
UniProt:O95208-2 EPN2
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:O15360 FANCA
1
FANCA [nucleoplasm]
(R-HSA-419541)
0.527
3
UniProt:Q8NB91 FANCB
1
FANCB [nucleoplasm]
(R-HSA-419528)
0.527
2
UniProt:Q8N2Z9 CENPS
2
APITD1 [cytosol]
(R-HSA-375310)
APITD1 [nucleoplasm]
(R-HSA-5633510)
0.524
2
IntAct:EBI-12506732 SPLAYED
0.524
2
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