Reactome | FANCA [nucleoplasm]

FANCA [nucleoplasm]

Stable Identifier

R-HSA-419541

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Fanconi anemia group A protein, FANCA_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P49146 NPY2R

Expand all

External Reference Information

External Reference

UniProt:O15360 FANCA

Gene Names

FANCA, FAA, FACA, FANCH

Chain

chain:1-1455

Reference Genes

BioGPS Gene:2175 FANCA

COSMIC (genes):FANCA FANCA

CTD Gene:2175 FANCA

dbSNP Gene:2175 FANCA

ENSEMBL:ENSG00000187741 FANCA

ENSEMBL_homo_sapiens_GENE:ENSG00000187741.16 FANCA

HGNC:3582 FANCA

KEGG Gene (Homo sapiens):2175 FANCA

Monarch:2175 FANCA

NCBI Gene:2175 FANCA

OMIM:607139 FANCA

UCSC:O15360 FANCA

Reference Transcript

Other Identifiers

11729472_a_at

11729473_at

11729474_x_at

11730303_a_at

11730304_at

11730305_at

11748438_a_at

11753325_a_at

16829369

203805_PM_s_at

203805_s_at

203806_PM_s_at

203806_s_at

215530_PM_at

215530_at

2175

33145_at

3704974

3704976

3704978

3704979

3704981

3704982

3704983

3704984

3704985

3704986

3704987

3704989

3704990

3704993

3704996

3704997

3704998

3705000

3705001

3705003

3705005

3705008

3705009

3705011

3705012

3705013

3705014

3705017

3705018

3705021

3705024

3705025

3705027

3705028

3705030

3705031

3705032

3705033

3705035

3705036

3705037

3705038

3705039

3705040

3705043

3705044

3705045

3705046

3705047

3705048

3705049

3705051

3705053

3705054

3705055

3705056

3705057

3705058

3705059

3705061

3705062

3705064

3705065

3705068

8003503

82955_at

A_23_P206441

A_33_P3286422

A_33_P3386344

GE60215

GO:0000785

GO:0002376

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006281

GO:0006954

GO:0006974

GO:0007140

GO:0008584

GO:0008585

GO:0022414

GO:0023052

GO:0030154

GO:0036297

GO:0043226

GO:0043240

GO:0045589

GO:0048856

GO:0050727

GO:0065003

GO:0140013

GO:1905936

GO:2000348

HMNXSV003040775

Hs.240138.0.S1_3p_at

Hs.240138.0.S1_3p_x_at

Hs.284153.0.A1_3p_a_at

ILMN_1769758

ILMN_1799224

PH_hs_0014712

TC16001357.hg

X99226_at

g4503654_3p_a_at

Participates

as a component of

as an input of

FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)

Other forms of this molecule

FANCA [cytosol]

Inferred To

Fanca [nucleoplasm] (Mus musculus)

Fanca [nucleoplasm] (Rattus norvegicus)

fanca [nucleoplasm] (Xenopus tropicalis)

FANCA [nucleoplasm] (Bos taurus)

FANCA [nucleoplasm] (Canis familiaris)

FANCA [nucleoplasm] (Gallus gallus)

FANCA [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001018122.1, NP_001273096.1, NP_000126.2

OpenTargets

ENSG00000187741

GeneCards

O15360

HPA

ENSG00000187741-FANCA

Ensembl

ENSP00000512517, ENST00000696275, ENSP00000373952, ENSP00000456829, ENST00000568369, ENSP00000373953, ENST00000389302, ENST00000389301, ENSG00000187741

PRO

O15360

Pharos - Targets

O15360

Orphanet

16020

PDB

7KZR, 7KZT, 7KZP, 7KZV, 7KZS, 7KZQ

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15287 FANCG	2	FANCG [nucleoplasm] (R-HSA-419532) FANCG [cytosol] (R-HSA-420788)	0.961	26
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.747	5
UniProt:Q00597 FANCC	2	FANCC [cytosol] (R-HSA-420801) FANCC [nucleoplasm] (R-HSA-419530)	0.678	3
UniProt:Q0VG06 FAAP100	2	FAAP100 [nucleoplasm] (R-HSA-419545) FAAP100 [cytosol] (R-HSA-420799)	0.662	4
UniProt:Q8NB91 FANCB	2	FANCB [nucleoplasm] (R-HSA-419528) FANCB [cytosol] (R-HSA-420791)	0.643	4
UniProt:Q9NW38 FANCL	2	FANCL [nucleoplasm] (R-HSA-419520) FANCL [cytosol] (R-HSA-420789)	0.597	3
UniProt:Q6NZ36-1 FAAP20			0.591	5
UniProt:Q9NPI8 FANCF	2	FANCF [cytosol] (R-HSA-420794) FANCF [nucleoplasm] (R-HSA-419537)	0.573	5
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.543	3
UniProt:Q8IYD8 FANCM	3	FANCM [nucleoplasm] (R-HSA-419535) p-S1045-FANCM [nucleoplasm] (R-HSA-6788401) FANCM [cytosol] (R-HSA-420802)	0.527	3
UniProt:Q5T5N4 CF118			0.527	2
UniProt:P49146 NPY2R	1	NPY2R [plasma membrane] (R-HSA-388905)	0.527	2
UniProt:P08173 CHRM4	1	CHRM4 [plasma membrane] (R-HSA-390693)	0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	3

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