Binding of Hsp90 to the LIMK proteins protects them from degradation and promotes their dimer formation and transphosphorylation. It is estimated that LIMK1 contains at least 5 phospho-amino acids primarily phospho-serines, in its kinase domain. The positions of these serine residues are not known. Transphosphorylation of these serine residues in LIMK1 increases its stability.
Yarden, Y, Soosairajah, J, Morton, CJ, Harari, D, Li, R, Bernard, O, Parker, MW, Ng, HL, Price, J, Citri, A
Kannourakis, G, Ganiatsas, S, Dringen, R, Bernard, O
Bernard, O
protein serine/threonine kinase activity of pLIMK dimer:HSP-90 [cytosol]
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