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MPP5 [plasma membrane]
Stable Identifier
R-HSA-419969
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
PALS1/MPP5, MAGUK p55 subfamily member 5, MPP5_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P54252 ATXN3
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Tight junction interactions (Homo sapiens)
Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions (Homo sapiens)
MPP5 [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 targets PDZ proteins in cell-cell junction (Homo sapiens)
Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions (Homo sapiens)
MPP5 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N3R9 MPP5
Gene Names
MPP5, PALS1
Chain
chain:1-675
Reference Genes
BioGPS Gene:64398 MPP5
COSMIC (genes):MPP5 MPP5
CTD Gene:64398 MPP5
dbSNP Gene:64398 MPP5
ENSEMBL:ENSG00000072415 MPP5
ENSEMBL_homo_sapiens_GENE:ENSG00000072415.10 MPP5
HGNC:18669 MPP5
KEGG Gene (Homo sapiens):64398 MPP5
Monarch:64398 MPP5
NCBI Gene:64398 MPP5
OMIM:606958 MPP5
UCSC:Q8N3R9 MPP5
Reference Transcript
RefSeq:NM_001256550.1 MPP5
RefSeq:NM_022474.3 MPP5
RefSeq:XM_005268003.1 MPP5
RefSeq:XM_011537086.2 MPP5
RefSeq:XM_011537087.2 MPP5
Other Identifiers
11718947_a_at
11718948_a_at
11718949_a_at
11718950_s_at
11718951_a_at
16785606
219321_PM_at
219321_at
226092_PM_at
226092_at
3541074
3541075
3541076
3541080
3541081
3541085
3541090
3541091
3541092
3541093
3541100
3541101
3541106
3541108
3541110
3541111
3541114
3541116
3541117
3541119
3541120
3541122
3541126
3541127
3541128
3541129
3541130
3541134
64398
65177_at
73186_at
7975203
A_14_P102313
A_23_P99536
A_24_P347458
A_33_P3248967
GE54852
GE82700
GO:0000166
GO:0002011
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005737
GO:0005793
GO:0005794
GO:0005886
GO:0005912
GO:0005923
GO:0007009
GO:0007163
GO:0008104
GO:0010467
GO:0012505
GO:0016020
GO:0016324
GO:0016332
GO:0017015
GO:0019904
GO:0021954
GO:0021987
GO:0023052
GO:0030154
GO:0030424
GO:0032287
GO:0032288
GO:0032991
GO:0033116
GO:0035749
GO:0035750
GO:0042802
GO:0042995
GO:0043204
GO:0043219
GO:0043220
GO:0043226
GO:0043296
GO:0045177
GO:0045197
GO:0048699
GO:0048856
GO:0061024
GO:0070062
GO:0070161
GO:0072659
HMNXSV003021778
Hs.13399.0.S1_3p_at
ILMN_1750689
PH_hs_0006032
TC14000403.hg
g11968024_3p_at
g11968024_3p_x_at
Participates
as a component of
CRB3:PALS1:PATJ complex [plasma membrane] (Homo sapiens)
as an input of
Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions (Homo sapiens)
Other forms of this molecule
MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane]
Cross References
RefSeq
NP_001243479.1
,
XP_005268060.1
,
XP_011535388.1
,
NP_071919.2
,
XP_011535389.1
OpenTargets
ENSG00000072415
GeneCards
Q8N3R9
HPA
ENSG00000072415-PALS1
Ensembl
ENST00000676464
,
ENST00000678380
,
ENST00000555925
,
ENST00000677382
,
ENSP00000503321
,
ENSP00000451488
,
ENSP00000503322
,
ENSG00000072415
,
ENSP00000261681
,
ENST00000261681
,
ENSP00000503517
,
ENST00000677835
,
ENSP00000503713
PRO
Q8N3R9
Pharos - Targets
Q8N3R9
PDB
7NTK
,
3UIT
,
4UU6
,
7QCS
,
4UU5
,
7NTJ
,
4WSI
,
1Y76
,
7M4R
Interactors (30)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14910 LIN7A
2
LIN7A [plasma membrane]
(R-HSA-5216076)
LIN7A [transport vesicle membrane]
(R-HSA-9610413)
0.871
10
UniProt:Q4VCS5 AMOT
0.802
7
UniProt:P0DTC4 E
9
N-glycan E [endoplasmic reticulum lumen]
(R-COV-9694754)
nascent E [endoplasmic reticulum lumen]
(R-COV-9694312)
3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9694305)
Ub-3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9694423)
Ub-3xPalmC-E [endoplasmic reticulum membrane]
(R-COV-9694465)
Ub-3xPalmC-E [Golgi membrane]
(R-COV-9694687)
Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698420)
Ub-3xPalmC-E [endocytic vesicle membrane]
(R-COV-9698422)
Ub-3xPalmC-E [virion membrane]
(R-COV-9698416)
0.798
6
UniProt:Q8NI35 PATJ
1
PATJ [plasma membrane]
(R-HSA-420011)
0.784
6
UniProt:P82279 CRUM1
0.779
5
UniProt:Q9NUP9 LIN7C
2
LIN7C [plasma membrane]
(R-HSA-5216165)
LIN7C [transport vesicle membrane]
(R-HSA-9610411)
0.742
6
UniProt:P59637 E
9
N-glycan E [endoplasmic reticulum lumen]
(R-COV-9683652)
Ub-3xPalmC-E [endoplasmic reticulum membrane]
(R-COV-9683767)
Ub-3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9683626)
3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9683597)
nascent E [endoplasmic reticulum lumen]
(R-COV-9683684)
Ub-3xPalmC-E [Golgi membrane]
(R-COV-9683694)
Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698721)
Ub-3xPalmC-E [endocytic vesicle membrane]
(R-COV-9698722)
Ub-3xPalmC-E [virion membrane]
(R-COV-9698716)
0.683
4
UniProt:P46937 YAP1
8
p-Y407-YAP1 [cytosol]
(R-HSA-9865208)
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
YAP1 [cytosol]
(R-HSA-1253345)
YAP1 [nucleoplasm]
(R-HSA-1253322)
0.671
5
UniProt:Q9HAP6 LIN7B
2
LIN7B [plasma membrane]
(R-HSA-5216107)
LIN7B [transport vesicle membrane]
(R-HSA-9610415)
0.666
5
UniProt:Q96JB8 MPP4
0.625
5
UniProt:Q8N3R9 MPP5
2
MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9689606)
MPP5 [plasma membrane]
(R-HSA-419969)
0.592
2
UniProt:Q9HCM4 EPB41L5
1
EPB41L5 [cytosol]
(R-HSA-6797564)
0.581
4
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
0.556
3
IntAct:EBI-23645769 CCSB ORF ID
0.556
3
UniProt:Q6PI77 GASP3
0.556
3
UniProt:Q9NY99-2 Q9NY992
0.556
3
UniProt:P54252 ATXN3
2
ATXN3 [nucleoplasm]
(R-HSA-6783285)
ATXN3 [cytosol]
(R-HSA-5625607)
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:Q9Y2H0-1 DLGAP4
0.556
3
UniProt:A0A286YEY3 A0A286YEY3
0.556
3
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:O95954 FTCD
1
FTCD [cytosol]
(R-HSA-70907)
0.556
3
UniProt:P02766 TTR
2
TTR [azurophil granule lumen]
(R-HSA-6799366)
TTR [extracellular region]
(R-HSA-976883)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:O75970 MPDZ
0.527
2
UniProt:Q8IY63 AMOTL1
1
AMOTL1 [cytosol]
(R-HSA-2028603)
0.527
3
UniProt:Q9Y2J4 AMOTL2
1
AMOTL2 [cytosol]
(R-HSA-2028606)
0.527
4
UniProt:Q8WXH5 SOCS4
1
SOCS4 [cytosol]
(R-HSA-8936109)
0.488
2
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