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CLDN2 [plasma membrane]
Stable Identifier
R-HSA-419994
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Claudin-2, CLD2_HUMAN
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Tight junction interactions (Homo sapiens)
Claudins create paired strands through homophilic and heterophilic cis and trans interactions (Homo sapiens)
Claudin [plasma membrane] (Homo sapiens)
CLDN2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P57739 CLDN2
Gene Names
CLDN2, PSEC0059, SP82, UNQ705/PRO1356
Chain
chain:1-230
Reference Genes
BioGPS Gene:9075 CLDN2
COSMIC (genes):CLDN2 CLDN2
CTD Gene:9075 CLDN2
dbSNP Gene:9075 CLDN2
ENSEMBL:ENSG00000165376 CLDN2
HGNC:2041 CLDN2
KEGG:hsa:9075 CLDN2
Monarch:9075 CLDN2
NCBI Gene:9075 CLDN2
OMIM:300520 CLDN2
UCSC:P57739 CLDN2
Reference Transcript
RefSeq:NM_020384.3 CLDN2
RefSeq:NM_001171095.1 CLDN2
RefSeq:NM_001171092.1 CLDN2
Other Identifiers
11724871_a_at
11724872_a_at
17105984
223509_PM_at
223509_at
3986345
3986347
3986348
3986349
3986350
3986351
3986352
3986353
3986354
3986355
3986356
3986357
3986358
3986371
3986377
48843_at
52766_at
8169210
89771_at
89774_at
9075
A_14_P126553
A_23_P394947
A_33_P3249046
GE57008
GO:0002227
GO:0002376
GO:0005198
GO:0005515
GO:0005886
GO:0005911
GO:0005923
GO:0007155
GO:0016020
GO:0016338
GO:0034330
GO:0042802
GO:0055085
GO:0070160
GO:0070830
GO:0098542
GO:0098609
GO:0120188
GO:0160184
GO:0160187
GO:1903985
GO:1904729
HMNXSV003046119
ILMN_1795190
PH_hs_0030722
TC0X000521.hg
g10503979_3p_at
Participates
as a candidate of
Claudin [plasma membrane] (Homo sapiens)
Other forms of this molecule
CLDN2 [cell junction]
Cross References
RefSeq
NP_001164566.1
,
NP_065117.1
,
NP_001164563.1
ENSEMBL
ENST00000541806
,
ENST00000336803
,
ENST00000540876
,
ENSP00000336571
,
ENSP00000441283
,
ENSP00000443230
OpenTargets
ENSG00000165376
HPA
ENSG00000165376-CLDN2
PRO
P57739
Pharos - Targets
P57739
HMDB Protein
HMDBP07608
PDB
4YYX
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.556
3
UniProt:P24593 IGFBP5
5
IGFBP5 [endoplasmic reticulum lumen]
(R-HSA-8956738)
p-IGFBP5 [endoplasmic reticulum lumen]
(R-HSA-8956988)
IGFBP5 [extracellular region]
(R-HSA-381414)
IGFBP5(21-163) [extracellular region]
(R-HSA-381415)
IGFBP5(164-272) [extracellular region]
(R-HSA-381478)
0.556
3
UniProt:O43561-2 LAT
2
p-5Y-LAT-2 [plasma membrane]
(R-HSA-2396597)
LAT-2 [plasma membrane]
(R-HSA-2396548)
0.556
3
UniProt:Q6UWB1 IL27RA
4
IL27RA [plasma membrane]
(R-HSA-448478)
p-Y611-IL27RA [plasma membrane]
(R-HSA-8950330)
sIL27RA [extracellular region]
(R-HSA-8950454)
sIL27RA [cytoplasm]
(R-HSA-8950653)
0.556
3
UniProt:Q13501 SQSTM1
7
SQSTM1 [cytosol]
(R-HSA-193937)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
0.537
4
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.537
4
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