Reactome | GIPR [plasma membrane]

GIPR [plasma membrane]

Stable Identifier

R-HSA-420132

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Gastric inhibitory polypeptide receptor, GIPR_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P48546 GIPR

Gene Names

GIPR

Chain

signal peptide:1-21, chain:22-466

Reference Genes

BioGPS Gene:2696 GIPR

COSMIC (genes):GIPR GIPR

CTD Gene:2696 GIPR

dbSNP Gene:2696 GIPR

ENSEMBL:ENSG00000010310 GIPR

ENSEMBL_homo_sapiens_GENE:ENSG00000010310.9 GIPR

HGNC:4271 GIPR

KEGG Gene (Homo sapiens):2696 GIPR

Monarch:2696 GIPR

NCBI Gene:2696 GIPR

OMIM:137241 GIPR

UCSC:P48546 GIPR

Reference Transcript

Other Identifiers

11737205_a_at

16863326

208105_PM_at

208105_at

231291_PM_at

231291_at

2696

35589_at

35590_s_at

3836402

3836404

3836405

3836406

3836407

3836409

3836410

3836412

3836413

3836415

3836417

3836420

3836421

3836424

3836425

3836426

3836427

3836428

3836429

3836430

3836431

8029728

85939_at

A_23_P119395

GE484454

GO:0002029

GO:0004888

GO:0004930

GO:0005515

GO:0005886

GO:0006091

GO:0007165

GO:0007166

GO:0007186

GO:0007188

GO:0007189

GO:0007190

GO:0007204

GO:0007584

GO:0008528

GO:0009749

GO:0016020

GO:0016519

GO:0017046

GO:0023052

GO:0031018

GO:0032024

GO:0038192

GO:0043950

GO:0048678

GO:0048856

GO:0050796

GO:0051592

GO:0060089

GO:0070542

GO:0120022

Hs.192855.0.A1_3p_at

ILMN_2082005

PH_hs_0013304

TC19000651.hg

U39231_at

X81832_s_at

g4503998_3p_at

Participates

as an input of

GIP receptor binds gastric inhibitory peptide (Homo sapiens)

as a member of

GPCRs that activate Gs [plasma membrane] (Homo sapiens)

as a component of

GIPR:GIP(52-93) [plasma membrane] (Homo sapiens)

Inferred To

GIPR [plasma membrane] (Bos taurus)

GIPR [plasma membrane] (Canis familiaris)

GIPR [plasma membrane] (Gallus gallus)

GIPR [plasma membrane] (Sus scrofa)

Gipr [plasma membrane] (Mus musculus)

Gipr [plasma membrane] (Rattus norvegicus)

gipr [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001295347.1, NP_000155.1

Guide to Pharmacology - Targets

248

OpenTargets

ENSG00000010310

ZINC - Substances

GIPR_HUMAN

ZINC target

P48546

PRO

P48546

PDB

7VAB, 7FIN, 4HJ0, 6DKJ, 2QKH, 7RBT, 7FIY, 7DTY, 7RA3

ZINC - Investigational

GIPR_HUMAN

GeneCards

P48546

HPA

ENSG00000010310-GIPR

Ensembl

ENSP00000305321, ENST00000304207, ENSP00000467494, ENSP00000263281, ENST00000590918, ENST00000263281, ENSG00000010310

Pharos - Targets

P48546

ZINC - Predictions - Purchasable

GIPR_HUMAN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09681 GIP	6	GIP(22-153) [endoplasmic reticulum lumen] (R-HSA-400512) GIP(22-153) [secretory granule lumen] (R-HSA-400526) GIP(52-93) [secretory granule lumen] (R-HSA-400483) GIP(54-93) [extracellular region] (R-HSA-400542) GIP(1-153) [endoplasmic reticulum lumen] (R-HSA-400470) GIP(52-93) [extracellular region] (R-HSA-400540)	0.618	3
UniProt:P01275 GCG	11	GCG(100-128) [extracellular region] (R-HSA-400472) ArgN-GCG(100-127) [extracellular region] (R-HSA-400534) GCG(1-180) [endoplasmic reticulum lumen] (R-HSA-400456) GCG(21-180) [endoplasmic reticulum lumen] (R-HSA-381774) GCG(21-180) [secretory granule lumen] (R-HSA-421418) ArgN-GCG(98-127) [secretory granule lumen] (R-HSA-421419) GLP-1 (7-37) [secretory granule lumen] (R-HSA-421422) GCG(146-178) [extracellular region] (R-HSA-420211) ArgN-GCG(98-127) [extracellular region] (R-HSA-381699) GLP-1 (7-37) [extracellular region] (R-HSA-381636) GCG(53-81) [extracellular region] (R-HSA-163626)	0.558	2