Reactome | RAMP3 [plasma membrane]

RAMP3 [plasma membrane]

Stable Identifier

R-HSA-420191

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Receptor activity-modifying protein 3, RAMP3_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        AMY1-3:IAPP(34-70) [plasma membrane] (Homo sapiens)
        
        AMY1-3 [plasma membrane] (Homo sapiens)
        
        AMY3 receptor [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
        
        Adrenomedullin receptor:ADM,ADM2 [plasma membrane] (Homo sapiens)
        
        Adrenomedullin receptor [plasma membrane] (Homo sapiens)
        
        CALCRL:RAMP3 [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        AMY1-3:IAPP(34-70) [plasma membrane] (Homo sapiens)
        
        AMY1-3 [plasma membrane] (Homo sapiens)
        
        AMY3 receptor [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
        
        Adrenomedullin receptor:ADM,ADM2 [plasma membrane] (Homo sapiens)
        
        Adrenomedullin receptor [plasma membrane] (Homo sapiens)
        
        CALCRL:RAMP3 [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        AMY1-3:IAPP(34-70) [plasma membrane] (Homo sapiens)
        
        AMY1-3 [plasma membrane] (Homo sapiens)
        
        AMY3 receptor [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
        
        Adrenomedullin receptor:ADM,ADM2 [plasma membrane] (Homo sapiens)
        
        Adrenomedullin receptor [plasma membrane] (Homo sapiens)
        
        CALCRL:RAMP3 [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        AMY1-3:IAPP(34-70) [plasma membrane] (Homo sapiens)
        
        AMY1-3 [plasma membrane] (Homo sapiens)
        
        AMY3 receptor [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
        
        Adrenomedullin receptor:ADM,ADM2 [plasma membrane] (Homo sapiens)
        
        Adrenomedullin receptor [plasma membrane] (Homo sapiens)
        
        CALCRL:RAMP3 [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        AMY1-3:IAPP(34-70) [plasma membrane] (Homo sapiens)
        
        AMY1-3 [plasma membrane] (Homo sapiens)
        
        AMY3 receptor [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
        
        Adrenomedullin receptor:ADM,ADM2 [plasma membrane] (Homo sapiens)
        
        Adrenomedullin receptor [plasma membrane] (Homo sapiens)
        
        CALCRL:RAMP3 [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        AMY1-3 [plasma membrane] (Homo sapiens)
        
        AMY3 receptor [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
        
        Adrenomedullin receptor [plasma membrane] (Homo sapiens)
        
        CALCRL:RAMP3 [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class B/2 (Secretin family receptors) (Homo sapiens)
      - Calcitonin-like ligand receptors (Homo sapiens)
        
        AMY1-3 bind IAPP(34-70) (Homo sapiens)
        
        AMY1-3 [plasma membrane] (Homo sapiens)
        
        AMY3 receptor [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
        
        AMY1-3:IAPP(34-70) [plasma membrane] (Homo sapiens)
        
        AMY1-3 [plasma membrane] (Homo sapiens)
        
        AMY3 receptor [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
        
        AMY1-3 bind pramlintide (Homo sapiens)
        
        AMY1-3 [plasma membrane] (Homo sapiens)
        
        AMY3 receptor [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
        
        AMY1-3:pramlintide [plasma membrane] (Homo sapiens)
        
        AMY1-3 [plasma membrane] (Homo sapiens)
        
        AMY3 receptor [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
        
        The adrenomedullin receptor can bind adrenomedullin and intermedin (Homo sapiens)
        
        Adrenomedullin receptor [plasma membrane] (Homo sapiens)
        
        CALCRL:RAMP3 [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)
        
        Adrenomedullin receptor:ADM,ADM2 [plasma membrane] (Homo sapiens)
        
        Adrenomedullin receptor [plasma membrane] (Homo sapiens)
        
        CALCRL:RAMP3 [plasma membrane] (Homo sapiens)
        
        RAMP3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60896 RAMP3

Gene Names

RAMP3

Chain

signal peptide:1-23, chain:24-148

Reference Genes

BioGPS Gene:10268 RAMP3

COSMIC - genes:RAMP3 RAMP3

CTD Gene:10268 RAMP3

dbSNP Gene:10268 RAMP3

ENSEMBL:ENSG00000122679 RAMP3

HGNC:9845 RAMP3

KEGG:hsa:10268 RAMP3

Monarch:10268 RAMP3

NCBI Gene:10268 RAMP3

OMIM:605155 RAMP3

UCSC:O60896 RAMP3

Reference Transcript

RefSeq:NM_005856.3 RAMP3

Other Identifiers

10268

11736590_a_at

17045787

17045794

205326_PM_at

205326_at

3000278

3000279

3000280

3000282

3000290

3000291

3000292

35152_at

8132660

A_14_P110482

A_23_P111737

GO:0001540

GO:0001605

GO:0001921

GO:0005515

GO:0005764

GO:0005886

GO:0006816

GO:0006886

GO:0007186

GO:0007189

GO:0008277

GO:0009986

GO:0010628

GO:0015026

GO:0015031

GO:0016020

GO:0016192

GO:0031623

GO:0032870

GO:0038041

GO:0043235

GO:0050850

GO:0051897

GO:0070374

GO:0071392

GO:0072659

GO:0086103

GO:0097643

GO:0097647

GO:0141163

GO:0150058

GO:0150061

GO:1903078

GO:1903143

GO:1904645

GO:1990410

HMNXSV003009761

ILMN_2065745

PH_hs_0002263

TC07000281.hg

TC07002289.hg

g5032022_3p_at

Participates

as a component of

Inferred To

RAMP3 [plasma membrane] (Bos taurus)

RAMP3 [plasma membrane] (Canis familiaris)

RAMP3 [plasma membrane] (Gallus gallus)

RAMP3 [plasma membrane] (Sus scrofa)

Ramp3 [plasma membrane] (Mus musculus)

Ramp3 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_005847.1

ENSEMBL

ENSP00000419012, ENST00000242249, ENST00000481345, ENSG00000122679, ENSP00000242249

OpenTargets

ENSG00000122679

GeneCards

RAMP3

HPA

ENSG00000122679-RAMP3

PRO

O60896

Pharos - Targets

O60896

GlyGen

O60896

HMDB Protein

HMDBP12702

PDB

8F2A, 8F0K, 9BTW, 6UVA, 8F2B, 7TZF, 6UUS

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:Q99527 GPER1	1	GPER1 [plasma membrane] (R-HSA-374191)	0.536	4
UniProt:Q99943 AGPAT1	1	AGPAT1 [endoplasmic reticulum membrane] (R-HSA-61803)	0.527	2
UniProt:Q969Z0 TBRG4	1	TBRG4 [mitochondrial matrix] (R-HSA-9837166)	0.527	2
UniProt:Q12846 STX4	4	STX4 [plasma membrane] (R-HSA-181519) STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.527	2
UniProt:Q7KYR7 BTN2A1	1	BTN2A1 [plasma membrane] (R-HSA-8851994)	0.527	3
UniProt:P31327 CPS1	20	CPS1 Q335* [mitochondrial matrix] (R-HSA-9956410) CPS1 R721* [mitochondrial matrix] (R-HSA-9955384) CPS1 E714* [mitochondrial matrix] (R-HSA-9956409) CPS1 Y140* [mitochondrial matrix] (R-HSA-9955433) CPS1 R787* [mitochondrial matrix] (R-HSA-9955402) CPS1 Q478* [mitochondrial matrix] (R-HSA-9955405) CPS1 Q44* [mitochondrial matrix] (R-HSA-9955390) CPS1 R238* [mitochondrial matrix] (R-HSA-9955391) CPS1 Y1031* [mitochondrial matrix] (R-HSA-9955440) CPS1 Q375* [mitochondrial matrix] (R-HSA-9955381) CPS1 R1262* [mitochondrial matrix] (R-HSA-9955431) CPS1 Q678P [mitochondrial matrix] (R-HSA-9955389) CPS1 T471N [mitochondrial matrix] (R-HSA-9955437) CPS1 P774L [mitochondrial matrix] (R-HSA-9955408) CPS1 T544M [mitochondrial matrix] (R-HSA-9955376) CPS1 A438P [mitochondrial matrix] (R-HSA-9955411) CPS1 R803G [mitochondrial matrix] (R-HSA-9955375) CPS1 R803S [mitochondrial matrix] (R-HSA-9955426) CPS1 V389C [mitochondrial matrix] (R-HSA-9955418) CPS1 N355D [mitochondrial matrix] (R-HSA-9955378)	0.527	2