Reactome | VIPR2 [plasma membrane]

VIPR2 [plasma membrane]

Stable Identifier

R-HSA-420227

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Vasoactive intestinal polypeptide receptor 2, VIPR2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        VIPR1,VIPR2:VIP(125-152) [plasma membrane] (Homo sapiens)
        
        VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
        
        VIPR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        VIPR1,VIPR2:VIP(125-152) [plasma membrane] (Homo sapiens)
        
        VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
        
        VIPR2 [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        VIPR1,VIPR2:VIP(125-152) [plasma membrane] (Homo sapiens)
        
        VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
        
        VIPR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        VIPR1,VIPR2:VIP(125-152) [plasma membrane] (Homo sapiens)
        
        VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
        
        VIPR2 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        VIPR1,VIPR2:VIP(125-152) [plasma membrane] (Homo sapiens)
        
        VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
        
        VIPR2 [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
        
        VIPR2 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class B/2 (Secretin family receptors) (Homo sapiens)
      - Glucagon-type ligand receptors (Homo sapiens)
        
        VIP receptors bind VIP (Homo sapiens)
        
        VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
        
        VIPR2 [plasma membrane] (Homo sapiens)
        
        VIPR1,VIPR2:VIP(125-152) [plasma membrane] (Homo sapiens)
        
        VIPR1,VIPR2 [plasma membrane] (Homo sapiens)
        
        VIPR2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P41587 VIPR2

Gene Names

VIPR2, VIP2R

Chain

signal peptide:1-23, chain:24-438

Reference Genes

BioGPS Gene:7434 VIPR2

COSMIC (genes):VIPR2 VIPR2

CTD Gene:7434 VIPR2

dbSNP Gene:7434 VIPR2

ENSEMBL:ENSG00000106018 VIPR2

HGNC:12695 VIPR2

KEGG:hsa:7434 VIPR2

Monarch:7434 VIPR2

NCBI Gene:7434 VIPR2

OMIM:601970 VIPR2

UCSC:P41587 VIPR2

Reference Transcript

Other Identifiers

11731162_a_at

11731163_at

17065017

205946_PM_at

205946_at

205947_PM_s_at

205947_s_at

211598_PM_x_at

211598_x_at

3082372

3082374

3082375

3082379

3082380

3082388

3082389

3082390

3082391

3082392

3082397

3082404

3082419

3082426

3082435

3082439

3082450

3082452

3082453

3082454

3082455

38954_at

4049244

4049246

7434

8144213

A_23_P145978

A_32_P153071

GE60344

GO:0001634

GO:0004888

GO:0004930

GO:0004999

GO:0005886

GO:0007165

GO:0007166

GO:0007186

GO:0007188

GO:0007189

GO:0007267

GO:0008528

GO:0016020

GO:0017046

GO:0023052

GO:0060089

HMNXSV003035945

HMNXSV003055090

Hs.2126.0.S2_3p_at

ILMN_1683939

ILMN_1811133

PH_hs_0031976

TC07002085.hg

X95097_rna1_s_at

g4507898_3p_s_at

Participates

as a member of

VIPR1,VIPR2 [plasma membrane] (Homo sapiens)

Inferred To

VIPR2 [plasma membrane] (Bos taurus)

VIPR2 [plasma membrane] (Canis familiaris)

VIPR2 [plasma membrane] (Sus scrofa)

Vipr2 [plasma membrane] (Mus musculus)

Vipr2 [plasma membrane] (Rattus norvegicus)

VPAC2 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_003373.2, NP_001291451.1, NP_001295188.1

Guide to Pharmacology - Targets

372

OpenTargets

ENSG00000106018

ENSEMBL

ENST00000262178, ENSP00000262178, ENSP00000366860, ENST00000377633, ENSG00000106018

ZINC - Substances

VIPR2_HUMAN

ZINC target

P41587

PRO

P41587

GlyGen

P41587

PDB

2X57, 7VQX, 7WBJ

HPA

ENSG00000106018-VIPR2

GeneCards

VIPR2

Pharos - Targets

P41587

ZINC - Predictions - Purchasable

VIPR2_HUMAN

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y3P9 RABGAP1	1	RABGAP1 [cytosol] (R-HSA-8854144)	0.643	4
UniProt:O60313 OPA1	3	OPA1 [mitochondrial inner membrane] (R-HSA-8867508) OPA1(88-194) [mitochondrial inner membrane] (R-HSA-8867509) OPA1(195-960) [mitochondrial inner membrane] (R-HSA-8867513)	0.527	2
UniProt:P06576 ATP5F1B	6	ATP5F1B [mitochondrial matrix] (R-HSA-164576) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B [mitochondrial inner membrane] (R-HSA-1299441)	0.527	3
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.527	2
UniProt:Q6YHU6 THADA	1	THADA [cytoplasm] (R-HSA-8870282)	0.527	2
UniProt:O43913 ORC5	1	ORC5 [nucleoplasm] (R-HSA-68516)	0.527	2
UniProt:Q9NSG2 FIRRM	4	FIRRM [nucleoplasm] (R-HSA-9853387) p-S43-FIRRM [cytosol] (R-HSA-9851990) p-S43,S744-FIRRM [cytosol] (R-HSA-9853437) FIRRM [cytosol] (R-HSA-9851948)	0.527	3
UniProt:O75845 SC5D	1	SC5D [endoplasmic reticulum membrane] (R-HSA-195662)	0.527	2
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.527	2
UniProt:Q7KZN9 COX15	1	COX15 [mitochondrial inner membrane] (R-HSA-2995350)	0.527	2
UniProt:O95427 PIGN	1	PIGN [endoplasmic reticulum membrane] (R-HSA-162724)	0.527	2
UniProt:P24468 NR2F2	1	NR2F2 [nucleoplasm] (R-HSA-1183002)	0.527	2
UniProt:P53794 SLC5A3	1	SLC5A3 [plasma membrane] (R-HSA-429592)	0.527	2
UniProt:P03905 MT-ND4	1	MT-ND4 [mitochondrial inner membrane] (R-HSA-60561)	0.527	3
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.527	2
UniProt:Q9NXB9 ELOVL2	1	ELOVL2 [endoplasmic reticulum membrane] (R-HSA-548677)	0.527	2
UniProt:Q8N6M3 FITM2	1	FITM2 [endoplasmic reticulum membrane] (R-HSA-8857678)	0.527	3
UniProt:Q969Z0 TBRG4	1	TBRG4 [mitochondrial matrix] (R-HSA-9837166)	0.527	2
UniProt:Q8N0U8 VKORC1L1	1	VKORC1L1 [endoplasmic reticulum membrane] (R-HSA-2980944)	0.527	2