Reactome | AMY1-3 bind IAPP(34-70)

AMY1-3 bind IAPP(34-70)

Stable Identifier

R-HSA-420265

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Amylin receptors can bind Amylin

ReviewStatus

5/5

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Amylin (islet amyloid polypeptide, diabetes associated peptide) is a 37 amino acid peptide first purified from amyloid deposits in the pancreatic islets of type 2 diabetic patients (Nishi M et al, 1989). It is a product of the islet B-cell, along with insulin and probably has a hormonal role in the regulation of nutrient intake. Amylin receptors are multimeric complexes, formed by CT receptor (Gorn AH et al, 1992) interaction with receptor activity modifying proteins (RAMPs) (McLatchie LM et al, 1998). The CT receptor interacts with the three RAMPs, generating multiple subtypes of amylin receptor (AMY1-3).

Literature References

PubMed ID	Title	Journal	Year
9620797	RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor Lee, MG, Solari, R, Fraser, NJ, McLatchie, LM, Foord, SM, Wise, A, Main, MJ, Thompson, N, Brown, J	Nature	1998
1331173	Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line Yamin, M, Lodish, HF, Flannery, MR, Auron, PE, Tapp, DR, Gorn, AH, Manning, CA, Goldring, SR, Krane, SM, Lin, HY	J Clin Invest	1992
2608057	Human islet amyloid polypeptide gene: complete nucleotide sequence, chromosomal localization, and evolutionary history Byers, MG, Nishi, M, Steiner, DF, Bell, GI, Eddy, RL, Seino, S, Fan, YS, Shows, TB, Sanke, T	Mol Endocrinol	1989