Reactome | ADCYAP1(132-169) [extracellular region]

ADCYAP1(132-169) [extracellular region]

Stable Identifier

R-HSA-420282

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Pituitary adenylate cyclase-activating polypeptide-38, ADCYAP1, PACA_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        ADCYAP1R1:ADCYAP1 peptides [plasma membrane] (Homo sapiens)
        
        ADCYAP1 peptides [extracellular region] (Homo sapiens)
        
        ADCYAP1(132-169) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        ADCYAP1R1:ADCYAP1 peptides [plasma membrane] (Homo sapiens)
        
        ADCYAP1 peptides [extracellular region] (Homo sapiens)
        
        ADCYAP1(132-169) [extracellular region] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        ADCYAP1R1:ADCYAP1 peptides [plasma membrane] (Homo sapiens)
        
        ADCYAP1 peptides [extracellular region] (Homo sapiens)
        
        ADCYAP1(132-169) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        ADCYAP1R1:ADCYAP1 peptides [plasma membrane] (Homo sapiens)
        
        ADCYAP1 peptides [extracellular region] (Homo sapiens)
        
        ADCYAP1(132-169) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        ADCYAP1R1:ADCYAP1 peptides [plasma membrane] (Homo sapiens)
        
        ADCYAP1 peptides [extracellular region] (Homo sapiens)
        
        ADCYAP1(132-169) [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
        
        ADCYAP1 peptides [extracellular region] (Homo sapiens)
        
        ADCYAP1(132-169) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class B/2 (Secretin family receptors) (Homo sapiens)
      - Glucagon-type ligand receptors (Homo sapiens)
        
        The PACAP receptor binds PACAP (Homo sapiens)
        
        ADCYAP1 peptides [extracellular region] (Homo sapiens)
        
        ADCYAP1(132-169) [extracellular region] (Homo sapiens)
        
        ADCYAP1R1:ADCYAP1 peptides [plasma membrane] (Homo sapiens)
        
        ADCYAP1 peptides [extracellular region] (Homo sapiens)
        
        ADCYAP1(132-169) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P18509 ADCYAP1

Gene Names

ADCYAP1

Chain

signal peptide:1-24, propeptide:25-79, peptide:82-129, peptide:132-169, peptide:132-158, propeptide:173-176

Reference Genes

BioGPS Gene:116 ADCYAP1

COSMIC (genes):ADCYAP1 ADCYAP1

CTD Gene:116 ADCYAP1

dbSNP Gene:116 ADCYAP1

ENSEMBL:ENSG00000141433 ADCYAP1

ENSEMBL_homo_sapiens_GENE:ENSG00000141433.13 ADCYAP1

HGNC:241 ADCYAP1

KEGG Gene (Homo sapiens):116 ADCYAP1

Monarch:116 ADCYAP1

NCBI Gene:116 ADCYAP1

OMIM:102980 ADCYAP1

UCSC:P18509 ADCYAP1

Reference Transcript

Other Identifiers

116

11729961_a_at

11729962_a_at

11738170_a_at

16850487

206281_PM_at

206281_at

230237_PM_at

230237_at

36754_at

3775921

3775922

3775923

3775924

3775930

3775932

3775936

3775937

3775938

3775939

3775940

3775941

3775942

3775943

3775944

48934_at

8019851

A_23_P38712

A_24_P335781

A_33_P3392092

GE59860

GO:0005102

GO:0005179

GO:0005184

GO:0005515

GO:0005576

GO:0006351

GO:0006355

GO:0007189

GO:0007190

GO:0007204

GO:0007218

GO:0007267

GO:0007399

GO:0007565

GO:0008277

GO:0010628

GO:0016521

GO:0019933

GO:0022414

GO:0023052

GO:0030073

GO:0030154

GO:0031175

GO:0032879

GO:0032880

GO:0036211

GO:0043005

GO:0043204

GO:0043547

GO:0045786

GO:0045860

GO:0045944

GO:0048018

GO:0048856

GO:0051428

GO:0060124

GO:0070374

GO:0071651

GO:0098772

GO:0120162

HMNXSV003030076

Hs.95469.0.A1_3p_at

ILMN_1763344

PH_hs_0004082

S83513_s_at

TC18000007.hg

g10947062_3p_at

Participates

as a member of

ADCYAP1 peptides [extracellular region] (Homo sapiens)

Other forms of this molecule

ADCYAP1(132-158) [extracellular region]

ADCYAP1(82-129) [extracellular region]

ADCYAP1(2-742) [Golgi membrane]

Inferred To

ADCYAP1 [extracellular region] (Bos taurus)

ADCYAP1 [extracellular region] (Canis familiaris)

ADCYAP1 [extracellular region] (Sus scrofa)

PACAP [extracellular region] (Gallus gallus)

adcyap1b [extracellular region] (Danio rerio)

Adcyap1 [extracellular region] (Mus musculus)

Adcyap1 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_001108.2, NP_001093203.1

OpenTargets

ENSG00000141433

HPA

ENSG00000141433-ADCYAP1

GeneCards

P18509

Ensembl

ENSG00000141433, ENST00000579794, ENST00000450565, ENSP00000462647, ENSP00000411658

ZINC target

P18509

PRO

P18509

Pharos - Targets

P18509

PDB

6VN7, 6M1I, 1GEA, 8E3X, 2JOD, 8E3Y, 7VQX, 6P9Y, 6LPB, 7WBJ, 2D2P

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41586-3 ADCYAP1R1			0.558	2
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P10909 CLU	4	CLU(23-449) [extracellular region] (R-HSA-349732) CLU(23-449) [platelet alpha granule lumen] (R-HSA-349733) CLU(228-449) [extracellular region] (R-HSA-6810626) CLU(23-227) [extracellular region] (R-HSA-6810660)	0.543	4
UniProt:Q6IN85 P4R3A			0.527	2
UniProt:Q02818 NUCB1	2	p-NUCB1 [endoplasmic reticulum lumen] (R-HSA-8957027) NUCB1 [endoplasmic reticulum lumen] (R-HSA-8956751)	0.527	2
UniProt:Q8IWJ2 GCC2	3	GCC2 [cytosol] (R-HSA-6813880) GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9713455) GCC2(1-1204)-ALK(1059-1620) fusion [cytosol] (R-HSA-9713458)	0.527	2
UniProt:P17707 AMD1	1	AMD1(1-67) [cytosol] (R-HSA-351223)	0.527	2
UniProt:Q9UHG2 PCS1N			0.527	2
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.527	2
UniProt:Q9H4B6 SAV1	2	SAV1 [cytosol] (R-HSA-2028283) p-SAV1 [cytosol] (R-HSA-2028276)	0.527	2
UniProt:O95749 GGPS1	1	GGPS1 [cytosol] (R-HSA-191415)	0.527	2
UniProt:Q9Y5J6 TIMM10B	1	4xHC-TIMM10B [mitochondrial inner membrane] (R-HSA-1252043)	0.527	2
UniProt:Q13188 STK3	4	p-T180-STK3(1-322) [cytosol] (R-HSA-2028696) STK3(323-491) [cytosol] (R-HSA-2028684) STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274)	0.527	2